Results 101 to 110 of about 990 (199)

SAT-456 Heterogeneity of Macroprolactin in Samples Suspected of False Hyperprolactinemia

Journal of the Endocrine Society, 2019
Circulating prolactin (PRL) exists in several molecular forms with different biological and immunological activities, in some instances making PRL measurements and its diagnostic value unreliable. Macroprolactin (macroPRL), a 150 kDa molecular weight (MW)
K. Nguyen, Rachel H Langevin, Michael J McPhaul, I. Hashim   +3 more
semanticscholar   +1 more source

Macroprolactin - prevalence, diagnostic methods and clinical significance

, 2009
Macroprolactin (MaPRL) is a high molecular mass variant of prolactin (PRL), which usually consists of a monomeric PRL and an immunoglobulin G molecule.
Beda, Karolina, Winczyk, Katarzyna
core  

Correlation of prolactin and macroprolactin levels with activity of Systemic Lupus Erythematosus before and after treatment

, 2006
Introdução: A prolactina (PRL) exerce efeitos imunoestimulatórios in vitro e in vivo, porém a literatura é controversa quanto ao papel deste hormônio na atividade do Lúpus Eritematoso Sistêmico (LES). A macroprolactina possui menor atividade biológica in
Ribeiro, Camila Toffoli, Camila Toffoli Ribeiro   +1 more
core   +1 more source

Screening for macroprolactinaemia and pituitary imaging studies

, 2002
OBJECTIVE Hyperprolactinaemia is caused by high levels of monomeric, dimeric or macro forms of prolactin in circulation, the monomeric form being predominant in patients with prolactinomas.
Maciel, Rui Monteiro de Barros [UNIFESP], Hauache, Omar Magid [UNIFESP], Rocha, A. J., Maia, ACM, Vieira, José Gilberto Henriques [UNIFESP]   +4 more
core   +1 more source

Association of Serum Prolactin Levels in Patients with Type 2 Diabetes Mellitus with and without Diabetic Nephropathy

Journal of Diabetology
Introduction: Diabetic nephropathy (DN), a common microvascular complication of type 2 diabetes mellitus (T2DM), contributes significantly to chronic kidney disease and is associated with increased morbidity. Prolactin (PRL), a hormone classically linked
Krishnan Kirubhakar, Subhash Chandra, Prabhat Kumar Agrawal, Ashwini Kumar Nigam, Suryakamal Verma, Pavan Gautam, Nimish Gupta, Sandipta Kumar Panda, Saurabh Tripathi, Priyanka Joshi   +9 more
doaj   +1 more source

[The diagnostic value of macroprolactin in hyperprolactinemia].

Klinicheskaia laboratornaia diagnostika, 2008
Macroprolactinemia (MP) in which there is a discrepancy between prolactin (P) levels and clinical symptoms has recently generated great interest among physicians of various specialties since not the whole of P is biologically active. The diagnosis of this condition is a topical problem.
L K, Dzeranova, N P, Goncharov, A D, Dobracheva, G S, Kolesnikova, E N, Giniiatullina, G A, Mel'nichenko   +5 more
openaire   +1 more source

Human macroprolactin biological activity study in Nb2 cells and in Ba/F-03 cells expressing human long prolactin receptor

, 2006
A macroprolactinemia é condição freqüente na hiperprolactinemia e em geral, sem impacto clínico. Os dados sobre a atividade biológica da macroprolactina (bbPRL) são controversos e baseados em bioensaio heterólogo com células de rato Nb2.
Glezer, Andrea, Andrea Glezer
core   +1 more source

Prolactin's diverse physiological roles and the clinical significance of hyperprolactinemia

Ginekologia Polska
OBJECTIVES: This review aims to provide a comprehensive overview of prolactin biology, encompassing its molecular heterogeneity, neuroendocrine regulation, and multifaceted roles in human health and disease, focusing on hyperprolactinemia.
Katarzyna Bocianska, Hubert Bochynski, Maksymilian Markwitz, Krzysztof Katulski   +3 more
doaj   +1 more source

Post-polyethylene glycol (PEG) treated prolactin levels for the detection of macroprolactin - time to change

, 2014
Objective: It has been shown that macroprolactin (MaPRL) is biologically inactive because the large molecular size of this complex prevents its crossing through the capillary blood barrier and reaching target cells. The aim of this study is to detect the
Khan, Aysha Habib, Sherazi, Noreen
core  

The Effect of Identifying Macroprolactinemia on Health-Care Utilization and Costs in Patients with Elevated Serum Prolactin Levels

, 2009
ObjectivesThe routine screening for macroprolactin of all hyperprolactinemic patients may avoid unnecessary imaging procedures and medication prescription.
Ferraz, Marcos Bosi, de Arêa Leão Souza, Silvia Corral, de Soárez, Patrícia Coelho, Vieira, José Gilberto Henriques   +3 more
core   +1 more source