Results 81 to 90 of about 990 (199)
Serum prolactin revisited: parametric reference intervals and cross platform evaluation of polyethylene glycol precipitation-based methods for discrimination between hyperprolactinemia and macroprolactinemia [PDF]
, 2017 Background:Hyperprolactinemia diagnosis and treatment is often compromised by the presence of biologically inactive and clinically irrelevant higher-molecular-weight complexes of prolactin, macroprolactin.
Susanne Møller Pedersen +3 more
core +1 more source
, 2005 Objective Three molecular forms of PRL with molecular weights of 23, 50-60 and > 100 kDa have been defined. The high-molecular-weight forms are called macroprolactin.
ŞİRİKÇİ, ÖNDER, YAVUZ, DİLEK
core +1 more source
Macroprolactin; a Frequent Cause of Misdiagnosed Hyperprolactinemia in Clinical Practice
, 2020 Introduction: Macroprolactin is a significant cause of misdiagnosis, unnecessary investigation, and inappropriate treatment in patients with hyperprolactinemia.
R Vaishya, R Gupta, S Arora
core
Thyroid Research, 2012 Background The so called “big-big” prolactin (Prl), also known as macroprolactin is formed by Prl-immunoglobulin (Prl-IgG) complexes and may cause elevation of serum Prl concentrations measured by standard assays, potentially leading to unnecessary ...
Lewandowski Krzysztof C +3 more
doaj +1 more source
Immunoprecipitation for Rapid Detection of Macroprolactin in the Form of Prolactin–Immunoglobulin Complexes [PDF]
Clinical Chemistry, 2005 The 3 major forms of serum prolactin (PRL), identifiable by gel-filtration chromatography (GFC), are monomeric PRL (23 kDa), big PRL (45–60 kDa), and big, big PRL or macroprolactin (150–170 kDa) (1). The common macroprolactin is PRL complexed with human IgG, but aggregates of PRL, some extensively glycosylated, may also occur (2)(3)(4)(5)(6 ...
Schiettecatte, Johan +6 more
openaire +3 more sources
Clinical characterization of patients with macroprolactinemia and monomeric hyperprolactinemia
Kaohsiung Journal of Medical Sciences, 2011 Macroprolactinemia is often a cause of misdiagnosis, unnecessary expensive investigation, and unsuitable treatment. The aim of the present study was to investigate the clinical findings and the concentrations of macroprolactin in patients with ...
Murat Can +4 more
doaj +1 more source
Macroprolactinemia in childhood and adolescence: a cause of hyperprolactinemia
The Turkish Journal of Pediatrics, 2006 Human prolactin consists of multiple forms of different sizes including three major prolactin (PRL) species, termed as little, big, and big-big PRL.
Filiz Tütüncüler +3 more
doaj +1 more source
Endocrine, 2016 Elevated prolactin levels seem to be associated with impaired sexuality. The clinical significance of macroprolactinemia, associated with the predominance of high molecular mass circulating forms of prolactin, is still poorly understood.
R. Krysiak +3 more
semanticscholar +1 more source
Evaluation of Clinical Features of Female Patients with Macroprolactinemia
Endocrinology Research and Practice, 2011 Aim: Macroprolactin is a high-molecular-weight form of prolactin. It has been suggested that macroprolactin has no clinical importance because of its decreased or limited bioactivity. Although screening for macroprolactinemia is recommended especially in
Alev Eroğlu Altınova +5 more
doaj +2 more sources
Macroprolactin-a cause of pseudohyperprolactinaemia.
Hong Kong medical journal = Xianggang yi xue za zhi, 2003 Macroprolactin is a complex of immunoglobulin G and monomeric prolactin with little biological activity in vivo. Macroprolactin cross-reacts in modern commercial prolactin assays, however, leading to pseudohyperprolactinaemia. This report is of three patients with macroprolactinaemia and the untoward consequences if this benign condition is ...
Y P, Yuen +4 more
openaire +1 more source