Results 51 to 60 of about 990 (199)

The Clinical Significance and Utility of Routine Screening for Macroprolactin in Patients With Hyperprolactinemia

Journal of the Endocrine Society, 2021
Background: Macroprolactin is a complex of monomeric prolactin (PRL) molecules with immunoglobulin G (IgG) that can result in the elevation of serum prolactin level.
W. Zeng, Thomas Frederick James King, T. Aw, Michael Chin Shern Lau   +3 more
semanticscholar   +1 more source

Macroprolactin Molecular Heterogeneity and Variable Immunoassay Reactivity

Journal of the Endocrine Society, 2021
Circulating prolactin (PRL) exhibits molecular heterogeneity the clinical significance of which is not known. Macroprolactin (mPRL) is widely reported, however, its heterogeneity is unknown.
I. Hashim, K. Nguyen, Rachel H Langevin, Michael J McPhaul   +3 more
semanticscholar   +1 more source

Contemporary approaches to the diagnosis of hyperprolactinemia

Репродуктивная эндокринология, 2019
Hyperprolactinemia (HP) is a persistent prolactin increase in serum. HP is a common endocrinopathy that impairs reproductive function, long term HP may lead to the metabolic disorders and a decrease in bone mineral density.
О. А. Бурка, Т. М. Тутченко   +1 more
doaj   +1 more source

Specificity and Clinical Utility of Methods for the Detection of Macroprolactin [PDF]

Clinical Chemistry, 2006
Abstract Background: Increased serum concentrations of macroprolactin are a relatively common cause of misdiagnosis and mismanagement of hyperprolactinemic patients. Methods: We studied sera from a cohort of 42 patients whose biochemical hyperprolactinemia was explained entirely by macroprolactin.
Lucille, Kavanagh, T Joseph, McKenna, Michael N, Fahie-Wilson, James, Gibney, Thomas P, Smith   +4 more
openaire   +2 more sources

Abnormally Elevated Follicle‐Stimulating Hormone (FSH) Level in an Infertile Woman

Case Reports in Endocrinology, Volume 2019, Issue 1, 2019., 2019
We report a case of 33‐year‐old woman with a 4‐year primary infertility. A high isolated follicle‐stimulating hormone (FSH) level was conflicting with the clinical situation and with other hormonal markers which were in favor of polycystic ovarian syndrome. We followed a strategy used to identify immune complexes involving FSH.
Aurore Catteau, Kalyane Bach-Ngohou, Justine Blin, Paul Barrière, Thomas Fréour, Damien Masson, Mihail A. Boyanov   +6 more
wiley   +1 more source

Assessment of intraindividual agreement in prolactin results after post-polyethylene glycol precipitation test for the estimation of macroprolactin. Should the precipitation procedure be repeated in the same patient?

Clinical Chemistry and Laboratory Medicine, 2020
Patients with high serum prolactin are usually screened for macroprolactinemia, which is a benign condition but may lead to a potential misdiagnosis of hyperprolactinemia.
Laura Jiménez-Añón, J. Barallat, D. Regidor, E. Urgell, M. Doladé, M. Granada   +5 more
semanticscholar   +1 more source

Stress‐Induced Hyperprolactinemia: Pathophysiology and Clinical Approach

Obstetrics and Gynecology International, Volume 2018, Issue 1, 2018., 2018
While prolactin is most well known for its role in lactation and suppression of reproduction, its physiological functions are quite diverse. There are many etiologies of hyperprolactinemia, including physiologic as well as pathologic causes. Physiologic causes include pregnancy, lactation, sleep‐associated, nipple stimulation and sexual orgasm, chest ...
Samara Levine, Ozgul Muneyyirci-Delale, Curt W. Burger   +2 more
wiley   +1 more source

Serum macroprolactin levels in pregnancy and association with thyroid autoimmunity [PDF]

BMC Endocrine Disorders, 2015
To assess the contribution of macroprolactin to high serum prolactin levels and their association with thyroid status and thyroid autoimmunity during pregnancy.138 pregnant women who suspected of having thyroid dysfunction were studied and divided into three groups according to the thyroid status; group 1; euthyroidism (n 40), group 2; hypothyroidism ...
Kisakol, Gurcan, Hacihasanoglu, Arif Bayram, Vatansever, Ebru, Kiyici, Sinem, Cander, Soner, Guclu, Metin   +5 more
openaire   +3 more sources

Tracking Macroprolactin: Use of an Optimized Polyethylene Glycol Precipitation Method More Compatible with the Requirements and Processes of Automated Core Laboratories.

The Journal of Applied Laboratory Medicine, 2017
Background: Macroprolactin (MPRL) is a large circulating form of a multimeric prolactin currently thought to be biologically inactive. Because of its ability to interfere with prolactin detection in most of the current 2-site immunoassays, the presence ...
J. Favresse, P. Bastin, C. Fillée, F. Luyckx, D. Maiter, D. Gruson   +5 more
semanticscholar   +2 more sources

Higher maternal serum prolactin levels are associated with reduced glucose tolerance during pregnancy

Journal of Diabetes Investigation, Volume 8, Issue 5, Page 697-700, September 2017., 2017
This study is the first to demonstrate the observation for the hypothesis that higher prolactin levels are associated with glucose intolerance during pregnancy. Prolactin has metabolic impacts beyond lactation. We propose that high levels of prolactin may contribute to pregnancy‐induced hyperglycaemia similar to its effects in prolactinoma. Abstract It
Elif I Ekinci, Niloufar Torkamani, Sabashini K Ramchand, Leonid Churilov, Ken A Sikaris, Zhong X Lu, Christine A Houlihan   +6 more
wiley   +1 more source