Results 1 to 10 of about 525,552 (330)
Generative mathematical modelling to demonstrate virtual simulations of neovascular age related macular degeneration. [PDF]
PLoS ONE, 2017 To develop a generative mathematical model of wet age-related macular degeneration (AMD) and model the impact of injections of anti-vascular endothelial growth factor to virtual patients with the condition.We isolated key pathophysiological components of
David Hoyle, Tariq Mehmood Aslam
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Sleep, Pain, and Neurodegeneration: A Mendelian Randomization Study
Frontiers in Neurology, 2022 Our aim was to determine whether the genetic liability to sleep and pain-related traits have a causal effect on risk of neurodegeneration in individuals of predominantly European ancestry. We selected five neurodegenerative disorders, namely, age-related
Sandeep Grover +2 more
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Innate immune biology in age-related macular degeneration
Frontiers in Cell and Developmental Biology, 2023 Age-related macular degeneration (AMD) is a neurodegenerative disease and a leading cause of irreversible vision loss in the developed world. While not classically described as an inflammatory disease, a growing body of evidence has implicated several ...
Karina Ascunce +4 more
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Classification of dry and wet macular degeneration based on the ConvNeXT model
Frontiers in Computational Neuroscience, 2022 PurposeTo assess the value of an automated classification model for dry and wet macular degeneration based on the ConvNeXT model.MethodsA total of 672 fundus images of normal, dry, and wet macular degeneration were collected from the Affiliated Eye ...
Maonian Wu +11 more
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PLoS ONE, 2021 ObjectiveThis study aimed to investigate the risk of Alzheimer's disease among patients with age-related macular degeneration and its association with confounding comorbidities.MethodThis was a population-based, retrospective cohort study.
Li-Yen Wen +9 more
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Peripapillary Intravitreal Injection Improves AAV-Mediated Retinal Transduction
Molecular Therapy: Methods & Clinical Development, 2020 The intravitreal (IVT) injection method is a choice when targeting the inner retina for gene therapy. However, the transduction efficiency of adeno-associated virus (AAV) vectors administered by the IVT route is usually low and may be affected by several
Sanjar Batirovich Madrakhimov +5 more
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Age Related Macular Degeneration and Total Hip Replacement Due to Osteoarthritis or Fracture: Melbourne Collaborative Cohort Study. [PDF]
PLoS ONE, 2015 Osteoarthritis is the leading cause of total hip replacement, accounting for more than 80% of all total hip replacements. Emerging evidence suggests that osteoarthritis has a chronic inflammatory component to its pathogenesis similar to age-related ...
Elaine W Chong +8 more
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PLoS ONE, 2023 BackgroundAge-related macular degeneration is the primary cause of irreversible blindness in developed countries, whereas the global prevalence of osteoporosis-a major public health problem-is 19.7%.
Agnieszka Budnik +9 more
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Complement C3 variant and the risk of age-related macular degeneration [PDF]
, 2007 Background: Age-related macular degeneration is the most common cause of blindness in Western populations. Susceptibility is influenced by age and by genetic and environmental factors.
Armbrecht, AM +16 more
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Molecular Therapy: Methods & Clinical Development, 2019 Adeno-associated virus (AAV) vector-mediated gene delivery is a promising approach for therapy, but implementation in the eye currently is hampered by the need for delivering the vector underneath the retina, using surgical application into the ...
Hongman Song +5 more
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