Results 1 to 10 of about 2,477 (190)

An updated version of the Madagascar periwinkle genome. [PDF]

F1000Res, 2022
The Madagascar periwinkle, Catharanthus roseus, belongs to the Apocynaceae family. This medicinal plant, endemic to Madagascar, produces many important drugs including the monoterpene indole alkaloids (MIA) vincristine and vinblastine used to treat ...
Cuello C, Stander EA, Jansen HJ, Dugé De Bernonville T, Oudin A, Birer Williams C, Lanoue A, Giglioli Guivarc'h N, Papon N, Dirks RP, Jensen MK, O'Connor SE, Besseau S, Courdavault V.   +13 more
europepmc   +7 more sources

Cellular and Subcellular Compartmentation of the 2C-Methyl-D-Erythritol 4-Phosphate Pathway in the Madagascar Periwinkle. [PDF]

Plants (Basel), 2020
The Madagascar periwinkle (Catharanthus roseus) synthesizes the highly valuable monoterpene indole alkaloids (MIAs) through a long metabolic route initiated by the 2C-methyl-D-erythritol 4-phosphate (MEP) pathway. In leaves, a complex compartmentation of
Guirimand G, Guihur A, Perello C, Phillips M, Mahroug S, Oudin A, Dugé de Bernonville T, Besseau S, Lanoue A, Giglioli-Guivarc'h N, Papon N, St-Pierre B, Rodríguez-Concepcíon M, Burlat V, Courdavault V.   +14 more
europepmc   +10 more sources

Ornamental exterior versus therapeutic interior of Madagascar periwinkle (Catharanthus roseus): the two faces of a versatile herb. [PDF]

ScientificWorldJournal, 2015
Catharanthus roseus (L.) known as Madagascar periwinkle (MP) is a legendary medicinal plant mostly because of possessing two invaluable antitumor terpenoid indole alkaloids (TIAs), vincristine and vinblastine.
Nejat N, Valdiani A, Cahill D, Tan YH, Maziah M, Abiri R.   +5 more
europepmc   +5 more sources

The Complete Plastid Genome Sequence of Madagascar Periwinkle Catharanthus roseus (L.) G. Don: Plastid Genome Evolution, Molecular Marker Identification, and Phylogenetic Implications in Asterids. [PDF]

PLoS One, 2013
The Madagascar periwinkle (Catharanthusroseus in the family Apocynaceae) is an important medicinal plant and is the source of several widely marketed chemotherapeutic drugs.
Ku C, Chung WC, Chen LL, Kuo CH.
europepmc   +2 more sources

Mechanistic and kinetic modeling of cadmium and lead phytoextraction by Madagascar Periwinkle [Catharanthus roseus (L.) G.Don] in battery waste contaminated soil. [PDF]

Sci Rep
Remediation of heavy metal-contaminated soils is critical due to their persistent toxicity and threat to food security and ecosystem health. Therefore, a study was conducted during September to November 2024 to assess the phytoextraction potential of ...
Al-Huqail AA, Goala M, Arya AK, Kumar P, Gupta D, Gaur SK, Širić I.   +6 more
europepmc   +2 more sources

Oxidation of four monoterpenoid indole alkaloid classes by three cytochrome P450 monooxygenases from Tabernaemontana litoralis. [PDF]

Plant J
SUMMARY Cytochrome P450 monooxygenases (CYPs) are well known for their ability to catalyze diverse oxidation reactions, playing a significant role in the biosynthesis of various natural products. In the realm of monoterpenoid indole alkaloids (MIAs), one of the largest groups of alkaloids in nature, CYPs are integral to reactions such as hydroxylation,
Mai Z, Kim K, Richardson MB, Deschênes DAR, Garza-Garcia JJO, Shahsavarani M, Perley JO, Njoku DI, Deslongchamps G, De Luca V, Qu Y.   +10 more
europepmc   +2 more sources

Explant origin and growth regulators as determinants of callus performance and terpenoid indole alkaloid accumulation in Catharanthus roseus. [PDF]

BMC Plant Biol
Catharanthus roseus (L.) G. Don (Apocynaceae) is a highly important medicinal plant and a valuable source of diverse pharmacologically active compounds particularly anticancer terpenoid indole alkaloids (TIAs), such as catharanthine (CAT), vinblastine ...
Desouky AF, El-Assal SE, Abdelsamad A, Reda AS, Danial N, Hanafy MS.   +5 more
europepmc   +2 more sources

Parallel evolution of methyltransferases leads to vobasine biosynthesis in Tabernaemontana elegans and Catharanthus roseus. [PDF]

Front Plant Sci
Monoterpenoid indole alkaloids (MIA) are one of the largest and most complex alkaloid class in nature, boasting many clinically significant drugs such as anticancer vinblastine and antiarrhythmic ajmaline.
Farzana M, Richardson MB, Deschênes DAR, Mai Z, Njoku DI, Deslongchamps G, Qu Y.   +6 more
europepmc   +2 more sources

Changes in the expression of CrFTA, the Catharanthus roseus farnesyltransferase α-subunit gene, in response to a Candidatus Liberibacter asiaticus infection

Czech Journal of Genetics and Plant Breeding, 2021
The farnesyltransferase α-subunit (FTA) may be involved in the regulation of defence responses against pathogens in plants. In this study, this gene was amplified from Catharanthus roseus (CrFTA gene).
Ya Li, Qinhan Yu
doaj   +1 more source

Fungal Elicitation Enhances Vincristine and Vinblastine Yield in the Embryogenic Tissues of Catharanthus roseus

Plants, 2023
Fungal elicitation could improve the secondary metabolite contents of in vitro cultures. Herein, we report the effect of Fusarium oxysporum on vinblastine and vincristine alkaloid yields in Catharanthus roseus embryos. The study revealed increased yields
Dipti Tonk, Abdul Mujib, Mehpara Maqsood, Mir Khusrau, Ali Alsughayyir, Yaser Hassan Dewir   +5 more
doaj   +1 more source