Effect of Aspergillus flavus Fungal Elicitor on the Production of Terpenoid Indole Alkaloids in Catharanthus roseus Cambial Meristematic Cells [PDF]
Molecules, 2018 This study reported the inducing effect of Aspergillus flavus fungal elicitor on biosynthesis of terpenoid indole alkaloids (TIAs) in Catharanthus roseus cambial meristematic cells (CMCs) and its inducing mechanism. According to the results determined by
Chuxin Liang +7 more
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Biosynthesis and regulation of terpenoid indole alkaloids in Catharanthus roseus.
Pharmacogn Rev, 2015 Catharanthus roseus produces a wide range of terpenoid indole alkaloids (TIA). Many of them, such as vinblastine and vincristine, have significant bioactivity. They are valuable chemotherapy drugs used in combination with other drugs to treat lymphoma and leukemia.
Zhu J, Wang M, Wen W, Yu R.
europepmc +4 more sources
Enhanced accumulation of anticancer compounds in C. roseus hairy root cultures through elicitation and precursor feeding [PDF]
Scientific ReportsCatharanthus roseus is a medicinal plant known for producing numerous indole terpenoid alkaloids. This study investigated the effects of methyl jasmonate, yeast extract, tryptophan, and tryptamine on the accumulation of four key alkaloids—ajmalicine ...
Mohamed R. Rady +2 more
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Evaluation of the expression pattern of TIAs pathway genes in response to tryptophan amino acid treatment and drought stress in Catharanthus roseus. [PDF]
PLoS ONEThe leaves of the medicinal-ornamental plant Catharanthus roseus serve as the exclusive source of the anticancer alkaloids vinblastine and vincristine.
Farshid Yousefi +5 more
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CrBPF1 overexpression alters transcript levels of terpenoid indole alkaloid biosynthetic and regulatory genes [PDF]
Frontiers in Plant Science, 2015 Terpenoid indole alkaloid (TIA) biosynthesis in Catharanthus roseus is a complex and highly regulated process. Understanding the biochemistry and regulation of the TIA pathway is of particular interest as it may allow the engineering of plants to ...
Chun Yao eLi +5 more
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Phenotypic Variability and Anticancer Alkaloid Profiles of Catharanthus roseus Cultivars Grown Under a Vertical Farming System [PDF]
PlantsPlants are promising biofactories for high-value compounds, and integrating vertical farming (VF) with plant molecular farming (PMF) enhances the efficiency and sustainability of these systems.
Marisa S. C. Lourenço +3 more
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New Methods of Analysis and Investigation of Terpenoid Indole Alkaloids
Advances in Botanical Research, 2013 Abstract Terpenoid indole alkaloids are biologically active compounds that have been used as pharmaceuticals among others as anticancer, antimalarial, antihypertensive and hypoglycemic agents for more than 40 years. Many efforts have been focused on their extraction, isolation, separation and structural elucidation by means of different approaches ...
Young Hae Choi, Robert Verpoorte
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Explant origin and growth regulators as determinants of callus performance and terpenoid indole alkaloid accumulation in Catharanthus roseus [PDF]
BMC Plant BiologyCatharanthus roseus (L.) G. Don (Apocynaceae) is a highly important medicinal plant and a valuable source of diverse pharmacologically active compounds particularly anticancer terpenoid indole alkaloids (TIAs), such as catharanthine (CAT), vinblastine ...
Abeer F. Desouky +5 more
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Synergistic effects of H2O2, melatonin, and L-cysteine on biochemical traits and alkaloid accumulation in Catharanthus roseus L. “Ocellatus” in vitro plants [PDF]
BMC Plant BiologyBackground Elicitation is a widely used strategy to enhance secondary metabolite production in medicinal plants. However, the comparative effectiveness of different redox-modulating elicitors and their interactions in regulating antioxidant systems and ...
Elham Jafarpour +3 more
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Frontiers in Genetics, 2022 Catharanthus roseus produces terpenoid indole alkaloids (TIAs) of high medicinal importance. The current research focuses on finding an efficient production system such as cell suspension cultures for high TIA concentrations.
Pengfei Zhou, Mingxiang Chen
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