Results 21 to 30 of about 2,469 (172)

Repression of ZCT1, ZCT2 and ZCT3 affects expression of terpenoid indole alkaloid biosynthetic and regulatory genes [PDF]

PeerJ, 2021
Terpenoid indole alkaloids (TIAs) include several valuable pharmaceuticals. As Catharanthus roseus remains the primary source of these TIA pharmaceuticals, several research groups have devoted substantial efforts to increase production of these compounds
Chun Yao Li, Susan I. Gibson
doaj   +2 more sources

Chromium-induced alkaloid production in Catharanthus roseus (L.) G.Don in vitro cultured shoots and related gene expression patterns particularly for the novel gene GS

Acta Agriculturae Slovenica, 2019
This study aimed to determine the effects of methyl jasmonate (Mj) combined with chromium (Cr) as elicitor on production of medicinal alkaloids, its antioxidant potential, and its effects on the expression of signaling and biosynthetic enzymes.
Elham KHATAEE, Farah KARIMI, Khadijeh RAZAVI   +2 more
doaj   +1 more source

Silencing the Transcriptional Repressor, ZCT1, Illustrates the Tight Regulation of Terpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus Hairy Roots. [PDF]

PLoS ONE, 2016
The Catharanthus roseus plant is the source of many valuable terpenoid indole alkaloids (TIAs), including the anticancer compounds vinblastine and vincristine.
Noreen F Rizvi, Jessica D Weaver, Erin J Cram, Carolyn W T Lee-Parsons   +3 more
doaj   +1 more source

Changing in the production of anticancer drugs (vinblastine and vincristine) in Catharanthus roseus (L.) G. Don by potassium and ascorbic acid treatments

Plant, Soil and Environment, 2022
Catharanthus roseus seedling was treated with different concentrations (1.5, 3.16, 15, and 30 mmol) and forms (K2SO4 and KNO3) of potassium (K+) via Hoagland's nutrient solution. Ascorbic acid (AsA) was sprayed twice (plant days 68 and 78) with different
Neda Sahi, Akbar Mostajeran, Mustafa Ghanadian   +2 more
doaj   +1 more source

Transcription factors involved in terpenoid indole alkaloid biosynthesis in Catharanthus roseus [PDF]

Phytochemistry Reviews, 2007
Plants produce alkaloids, among others, to protect themselves against microbial infection, herbivore attack or ultraviolet irradiation. For man, alkaloid metabolism is the source of many natural products with useful applications, including pharmaceuticals.
Memelink, J., Gantet, P.
openaire   +1 more source

Beyond Gut Modulation: A Critical Review of the Therapeutic Potential, Safety, and Clinical Prospects of Natural Polysaccharides for IBD

Food Safety and Health, EarlyView.
In this review, we critically summarized the application of natural polysaccharides (NPs) for the treatment of IBD. This approach combines, in a unique way (right), the basic structure–activity relationships of NPs from different origins (left) with their multipronged mode of action, which involves modulation of the gut microbiota and other ...
Felix Danso, A. M. Abd El‐Aty, Kwaku Amoah, Xianghong Ju   +3 more
wiley   +1 more source

Gene-to-metabolite networks for terpenoid indole alkaloid biosynthesis in Catharanthus roseus cells [PDF]

Proceedings of the National Academy of Sciences, 2006
Rational engineering of complicated metabolic networks involved in the production of biologically active plant compounds has been greatly impeded by our poor understanding of the regulatory and metabolic pathways underlying the biosynthesis of these compounds.
Oresic, Matej, Seppänen-Laakso, Tuulikki, Katajamaa, Mikko, Lammertyn, Freya, Ardiles-Diaz, Wilson, Van Montagu, Marc C. E., Inzé, Dirk, Oksman-Caldentey, Kirsi-Marja, Goossens, Alain, Rischer, Heiko   +10 more
openaire   +4 more sources

Review of abiotic and biotic elicitors’ roles in secondary metabolites biosynthesis of periwinkle (Catharanthus roseus (Linn.) G. Don)

Journal of Medicinal Plants, 2020
Background: Based on recent statistical survey, the cancer is the third important factor in Iran mortality. Vinblastine and vincristine alkaloids are dominantly biosynthesized in the aerial parts of periwinkle, broadly applied for cancer treatment ...
Saleh Amiri, Reza Fotovat, Bahman Panahi, Alireza Tarinezhad, Seyyed Abolghasem Mohammadi   +4 more
doaj  

Artemisinic Acid Serves as a Novel Inducer to Enhance Biosynthesis of Terpenoid Indole Alkaloids in Cambial Meristematic Cells

Natural Product Communications, 2016
To investigate the effect of artemisinic acid (AA) on improving the production of terpenoid indole alkaloids (TIAs) of Catharanthus roseus cambial meristematic cells (CMCs), feeding AA to C.
Mingxuan Wang, Jiachen Zi, Jianhua Zhu, Shan Chen, Pu Wang, Liyan Song, Rongmin Yu   +6 more
doaj   +1 more source

Improvement of Phytopharmaceutical and Alkaloid Production in Periwinkle Plants by Endophyte and Abiotic Elicitors

Horticulturae, 2022
Periwinkle plant represents a major source of immensely vital terpenoid indole alkaloids and natural antioxidants which are widely used in cancer chemotherapy.
Saad Farouk, Arwa Abdulkreem AL-Huqail, Seham M. A. El-Gamal   +2 more
doaj   +1 more source