Results 11 to 20 of about 4,886 (206)
Methyljasmonate Elicitation Increases Terpenoid Indole Alkaloid Accumulation in Rhazya stricta Hairy Root Cultures [PDF]
Plants, 2019 Methyl jasmonate is capable of initiating or improving the biosynthesis of secondary metabolites in plants and therefore has opened up a concept for the biosynthesis of valuable constituents.
Amir Akhgari +6 more
doaj +5 more sources
CrBPF1 overexpression alters transcript levels of terpenoid indole alkaloid biosynthetic and regulatory genes [PDF]
Frontiers in Plant Science, 2015 Terpenoid indole alkaloid (TIA) biosynthesis in Catharanthus roseus is a complex and highly regulated process. Understanding the biochemistry and regulation of the TIA pathway is of particular interest as it may allow the engineering of plants to ...
Chun Yao eLi +5 more
doaj +3 more sources
Biosynthesis and regulation of terpenoid indole alkaloids in Catharanthus roseus.
Pharmacogn Rev, 2015 Catharanthus roseus produces a wide range of terpenoid indole alkaloids (TIA). Many of them, such as vinblastine and vincristine, have significant bioactivity. They are valuable chemotherapy drugs used in combination with other drugs to treat lymphoma and leukemia.
Zhu J, Wang M, Wen W, Yu R.
europepmc +4 more sources
Journal of Pure and Applied Microbiology, 2021 The medicinal plant C. roseus synthesizes biologically active alkaloids via the terpenoid indole alkaloid (TIAs) biosynthetic pathway. Most of these alkaloids have high therapeutic value, such as vinblastine and vincristine.
Mukesh Kumar Sharma, Mohan Kumar, Renu
doaj +1 more source
Plants, 2021 Cell and tissue cultures of Catharanthus roseus have been studied extensively as an alternative strategy to improve the production of valuable secondary metabolites. The purpose of this study was to produce C. roseus callus and suspension cell biomass of
Tran My Linh +6 more
doaj +1 more source
Transcription factors involved in terpenoid indole alkaloid biosynthesis in [PDF]
Phytochemistry Reviews, 2007 Plants produce alkaloids, among others, to protect themselves against microbial infection, herbivore attack or ultraviolet irradiation. For man, alkaloid metabolism is the source of many natural products with useful applications, including pharmaceuticals.
Memelink, J., Gantet, P.
core +3 more sources
Catharanthus terpenoid indole alkaloids: biosynthesis and regulation [PDF]
Phytochemistry Reviews, 2007 Catharanthus roseus is still the only source for the powerful antitumour drugs vinblastine and vincristine. Some other pharmaceutical compounds from this plant, ajmalicine and serpentine are also of economical importance. Although C. roseus has been studied extensively and was subject of numerous publications, a full characterization of its alkaloid ...
El-Sayed, Magdi, Verpoorte, Rob
openaire +1 more source
Frontiers in Plant Science, 2022 Dendrobium officinale is both a traditional herbal medicine and a plant of high ornamental and medicinal value. Alkaloids, especially terpenoid indole alkaloids (TIAs), with pharmacological activities are present in the tissues of D. officinale. A number
Chunyan Jiao +8 more
doaj +1 more source
Scientific Reports, 2022 The anti-cancer vinblastine and vincristine alkaloids can only be naturally found in periwinkle (Catharanthus roseus). Both of these alkaloids' accumulations are known to be influenced by salicylic acid (SA).
Narges Soltani +4 more
doaj +1 more source
Indole diterpenoid natural products as the inspiration for new synthetic methods and strategies. [PDF]
, 2017 Indole terpenoids comprise a large class of natural products with diverse structural topologies and a broad range of biological activities. Accordingly, indole terpenoids have and continue to serve as attractive targets for chemical synthesis.
Corsello, Michael A +2 more
core +1 more source