Results 11 to 20 of about 2,466 (171)

Biosynthesis and Modulation of Terpenoid Indole Alkaloids in Catharanthus roseus: A Review of Targeting Genes and Secondary Metabolites

Journal of Pure and Applied Microbiology, 2021
The medicinal plant C. roseus synthesizes biologically active alkaloids via the terpenoid indole alkaloid (TIAs) biosynthetic pathway. Most of these alkaloids have high therapeutic value, such as vinblastine and vincristine.
Mukesh Kumar Sharma, Mohan Kumar, Renu
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Development of a Cell Suspension Culture System for Promoting Alkaloid and Vinca Alkaloid Biosynthesis Using Endophytic Fungi Isolated from Local Catharanthus roseus

Plants, 2021
Cell and tissue cultures of Catharanthus roseus have been studied extensively as an alternative strategy to improve the production of valuable secondary metabolites. The purpose of this study was to produce C. roseus callus and suspension cell biomass of
Tran My Linh, Nguyen Chi Mai, Pham Thi Hoe, Ninh Thi Ngoc, Phan Thi Hong Thao, Ninh Khac Ban, Nguyen Tuong Van   +6 more
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Transcriptomic analysis of genes related to alkaloid biosynthesis and the regulation mechanism under precursor and methyl jasmonate treatment in Dendrobium officinale

Frontiers in Plant Science, 2022
Dendrobium officinale is both a traditional herbal medicine and a plant of high ornamental and medicinal value. Alkaloids, especially terpenoid indole alkaloids (TIAs), with pharmacological activities are present in the tissues of D. officinale. A number
Chunyan Jiao, Chunyan Jiao, Mengke Wei, Honghong Fan, Cheng Song, Zhanjun Wang, Zhanjun Wang, Yongping Cai, Qing Jin   +8 more
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Catharanthus terpenoid indole alkaloids: biosynthesis and regulation [PDF]

Phytochemistry Reviews, 2007
Catharanthus roseus is still the only source for the powerful antitumour drugs vinblastine and vincristine. Some other pharmaceutical compounds from this plant, ajmalicine and serpentine are also of economical importance. Although C. roseus has been studied extensively and was subject of numerous publications, a full characterization of its alkaloid ...
El-Sayed, Magdi, Verpoorte, Rob
openaire   +1 more source

De Novo transcriptome assembly and differential expression analysis of catharanthus roseus in response to salicylic acid

Scientific Reports, 2022
The anti-cancer vinblastine and vincristine alkaloids can only be naturally found in periwinkle (Catharanthus roseus). Both of these alkaloids' accumulations are known to be influenced by salicylic acid (SA).
Narges Soltani, Farhad Nazarian Firouzabadi, Alireza Shafeinia, Masoud Shirali, Ayeh Sadat Sadr   +4 more
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Chemical constituents from Tabernaemontana catharinensis root bark: a brief NMR review of indole alkaloids and in vitro cytotoxicity

Química Nova, 2008
This work describes the isolation and structural determination of pharmacological compounds present in the bark of roots of Tabernaemontana catharinensis (Apocynaceae).
Paulo Sérgio Pereira, Suzelei de Castro França, Paulo Vinicius Anderson de Oliveira, Camila Moniz de Souza Breves, Sarazete Izidia Vaz Pereira, Suely Vilela Sampaio, Auro Nomizo, Diones Aparecida Dias   +7 more
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Analysis of Indole Alkaloids from Rhazya stricta Hairy Roots by Ultra-Performance Liquid Chromatography-Mass Spectrometry

Molecules, 2015
Rhazya stricta Decne. (Apocynaceae) contains a large number of terpenoid indole alkaloids (TIAs). This study focused on the composition of alkaloids obtained from transformed hairy root cultures of R.
Amir Akhgari, Into Laakso, Tuulikki Seppänen-Laakso, Teijo Yrjönen, Heikki Vuorela, Kirsi-Marja Oksman-Caldentey, Heiko Rischer   +6 more
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Acute and Sub-Acute Toxicological Evaluations of Bioactive Alkaloidal Extract from Melodinus henryi and Their Main Chemical Constituents

Natural Products and Bioprospecting, 2020
Melodinus henryi is a good source of terpenoid indole alkaloids, and traditionally used as a folk medicine in the treatment of meningitis and fracture.
Meilian Yang, Yudan Wang, Zhifeng Fan, Qingwang Xue, Guy Sedar Singor Njateng, Yaping Liu, Jianxin Cao, Tianrui Zhao, Guiguang Cheng   +8 more
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Indole Alkaloids from Catharanthus roseus: Bioproduction and Their Effect on Human Health

Molecules, 2015
Catharanthus roseus is a medicinal plant belonging to the family Apocynaceae which produces terpenoid indole alkaloids (TIAs) of high medicinal importance.
Lorena Almagro, Francisco Fernández-Pérez, Maria Angeles Pedreño   +2 more
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Metabolomic responses to the mechanical wounding of Catharanthus roseus’ upper leaves [PDF]

PeerJ, 2023
Purpose Plant secondary metabolites are used to treat various human diseases. However, it is difficult to produce a large number of specific metabolites, which largely limits their medicinal applications.
Qi Chen, Yan Jin, Xiaorui Guo, Mingyuan Xu, Guanyun Wei, Xueyan Lu, Zhonghua Tang   +6 more
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