Results 11 to 20 of about 2,469 (172)
CrBPF1 overexpression alters transcript levels of terpenoid indole alkaloid biosynthetic and regulatory genes [PDF]
Frontiers in Plant Science, 2015 Terpenoid indole alkaloid (TIA) biosynthesis in Catharanthus roseus is a complex and highly regulated process. Understanding the biochemistry and regulation of the TIA pathway is of particular interest as it may allow the engineering of plants to ...
Chun Yao eLi +5 more
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Biosynthesis and regulation of terpenoid indole alkaloids in Catharanthus roseus.
Pharmacogn Rev, 2015 Catharanthus roseus produces a wide range of terpenoid indole alkaloids (TIA). Many of them, such as vinblastine and vincristine, have significant bioactivity. They are valuable chemotherapy drugs used in combination with other drugs to treat lymphoma and leukemia.
Zhu J, Wang M, Wen W, Yu R.
europepmc +4 more sources
Scientific Reports, 2022 The anti-cancer vinblastine and vincristine alkaloids can only be naturally found in periwinkle (Catharanthus roseus). Both of these alkaloids' accumulations are known to be influenced by salicylic acid (SA).
Narges Soltani +4 more
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Catharanthus terpenoid indole alkaloids: biosynthesis and regulation [PDF]
Phytochemistry Reviews, 2007 Catharanthus roseus is still the only source for the powerful antitumour drugs vinblastine and vincristine. Some other pharmaceutical compounds from this plant, ajmalicine and serpentine are also of economical importance. Although C. roseus has been studied extensively and was subject of numerous publications, a full characterization of its alkaloid ...
El-Sayed, Magdi, Verpoorte, Rob
openaire +1 more source
Química Nova, 2008 This work describes the isolation and structural determination of pharmacological compounds present in the bark of roots of Tabernaemontana catharinensis (Apocynaceae).
Paulo Sérgio Pereira +7 more
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Molecules, 2015 Rhazya stricta Decne. (Apocynaceae) contains a large number of terpenoid indole alkaloids (TIAs). This study focused on the composition of alkaloids obtained from transformed hairy root cultures of R.
Amir Akhgari +6 more
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Natural Products and Bioprospecting, 2020 Melodinus henryi is a good source of terpenoid indole alkaloids, and traditionally used as a folk medicine in the treatment of meningitis and fracture.
Meilian Yang +8 more
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Indole Alkaloids from Catharanthus roseus: Bioproduction and Their Effect on Human Health
Molecules, 2015 Catharanthus roseus is a medicinal plant belonging to the family Apocynaceae which produces terpenoid indole alkaloids (TIAs) of high medicinal importance.
Lorena Almagro +2 more
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Plant Direct, 2021 Basic helix‐loop‐helix (bHLH) transcription factors (TFs) are key regulators of plant specialized metabolites, including terpenoid indole alkaloids (TIAs) in Catharanthus roseus.
Sanjay Kumar Singh +5 more
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Metabolomic responses to the mechanical wounding of Catharanthus roseus’ upper leaves [PDF]
PeerJ, 2023 Purpose Plant secondary metabolites are used to treat various human diseases. However, it is difficult to produce a large number of specific metabolites, which largely limits their medicinal applications.
Qi Chen +6 more
doaj +2 more sources