Results 11 to 20 of about 134,369 (196)

Chemical constituents from Tabernaemontana catharinensis root bark: a brief NMR review of indole alkaloids and in vitro cytotoxicity [PDF]

Química Nova, 2008
This work describes the isolation and structural determination of pharmacological compounds present in the bark of roots of Tabernaemontana catharinensis (Apocynaceae).
Paulo Sérgio Pereira, Suzelei de Castro França, Paulo Vinicius Anderson de Oliveira, Camila Moniz de Souza Breves, Sarazete Izidia Vaz Pereira, Suely Vilela Sampaio, Auro Nomizo, Diones Aparecida Dias   +7 more
doaj   +2 more sources

Gene-to-metabolite networks for terpenoid indole alkaloid biosynthesis in Catharanthus roseus cells [PDF]

Proceedings of the National Academy of Sciences, 2006
Rational engineering of complicated metabolic networks involved in the production of biologically active plant compounds has been greatly impeded by our poor understanding of the regulatory and metabolic pathways underlying the biosynthesis of these compounds.
Oresic, Matej, Seppänen-Laakso, Tuulikki, Katajamaa, Mikko, Lammertyn, Freya, Ardiles-Diaz, Wilson, Van Montagu, Marc C. E., Inzé, Dirk, Oksman-Caldentey, Kirsi-Marja, Goossens, Alain, Rischer, Heiko   +10 more
openaire   +5 more sources

Development of a Cell Suspension Culture System for Promoting Alkaloid and Vinca Alkaloid Biosynthesis Using Endophytic Fungi Isolated from Local Catharanthus roseus

Plants, 2021
Cell and tissue cultures of Catharanthus roseus have been studied extensively as an alternative strategy to improve the production of valuable secondary metabolites. The purpose of this study was to produce C. roseus callus and suspension cell biomass of
Tran My Linh, Nguyen Chi Mai, Pham Thi Hoe, Ninh Thi Ngoc, Phan Thi Hong Thao, Ninh Khac Ban, Nguyen Tuong Van   +6 more
doaj   +1 more source

Transcriptomic analysis of genes related to alkaloid biosynthesis and the regulation mechanism under precursor and methyl jasmonate treatment in Dendrobium officinale

Frontiers in Plant Science, 2022
Dendrobium officinale is both a traditional herbal medicine and a plant of high ornamental and medicinal value. Alkaloids, especially terpenoid indole alkaloids (TIAs), with pharmacological activities are present in the tissues of D. officinale. A number
Chunyan Jiao, Chunyan Jiao, Mengke Wei, Honghong Fan, Cheng Song, Zhanjun Wang, Zhanjun Wang, Yongping Cai, Qing Jin   +8 more
doaj   +1 more source

De Novo transcriptome assembly and differential expression analysis of catharanthus roseus in response to salicylic acid

Scientific Reports, 2022
The anti-cancer vinblastine and vincristine alkaloids can only be naturally found in periwinkle (Catharanthus roseus). Both of these alkaloids' accumulations are known to be influenced by salicylic acid (SA).
Narges Soltani, Farhad Nazarian Firouzabadi, Alireza Shafeinia, Masoud Shirali, Ayeh Sadat Sadr   +4 more
doaj   +1 more source

Catharanthus terpenoid indole alkaloids: biosynthesis and regulation [PDF]

Phytochemistry Reviews, 2007
Catharanthus roseus is still the only source for the powerful antitumour drugs vinblastine and vincristine. Some other pharmaceutical compounds from this plant, ajmalicine and serpentine are also of economical importance. Although C. roseus has been studied extensively and was subject of numerous publications, a full characterization of its alkaloid ...
El-Sayed, Magdi, Verpoorte, Rob
openaire   +1 more source

Analysis of Indole Alkaloids from Rhazya stricta Hairy Roots by Ultra-Performance Liquid Chromatography-Mass Spectrometry

Molecules, 2015
Rhazya stricta Decne. (Apocynaceae) contains a large number of terpenoid indole alkaloids (TIAs). This study focused on the composition of alkaloids obtained from transformed hairy root cultures of R.
Amir Akhgari, Into Laakso, Tuulikki Seppänen-Laakso, Teijo Yrjönen, Heikki Vuorela, Kirsi-Marja Oksman-Caldentey, Heiko Rischer   +6 more
doaj   +1 more source

Strictosidine, the common precursor for monoterpenoid indole alkaloids with 3 α and 3 β configuration [PDF]

, 1978
Recently we reported that strictosidine (l> is the key intermediate in the formation of the three classes (ASDidOf3DeIm5, Iboga, Corynanthe) of monoterpenoid indole alkaloids In Catharanthus roseus and a variety of other plant species in cell culture ...
Martina Rueffer, Rüffer, Martina, Nagakura, Naotaka, Zenk, Meinhart H., Meinhart H. Zenk, Naotaka Nagakura   +5 more
core   +1 more source

Acute and Sub-Acute Toxicological Evaluations of Bioactive Alkaloidal Extract from Melodinus henryi and Their Main Chemical Constituents

Natural Products and Bioprospecting, 2020
Melodinus henryi is a good source of terpenoid indole alkaloids, and traditionally used as a folk medicine in the treatment of meningitis and fracture.
Meilian Yang, Yudan Wang, Zhifeng Fan, Qingwang Xue, Guy Sedar Singor Njateng, Yaping Liu, Jianxin Cao, Tianrui Zhao, Guiguang Cheng   +8 more
doaj   +1 more source

CH activation and CH2 double activation of indolines: towards the synthesis of aspidospermidine and aspidofractinine [PDF]

, 2009
This thesis is concerned with the total synthesis of the two Aspidosperma alkaloid natural products, aspidospermidine and aspidofractinine. The two targets have a common pentacyclic molecular framework unique to this class of indole alkaloids ...
Whiting, Sally
core   +2 more sources