Results 41 to 50 of about 4,886 (206)

Chemical screening identifies the β-Carboline alkaloid harmine to be synergistically lethal with doxorubicin. [PDF]

, 2017
Despite being an invaluable chemotherapeutic agent for several types of cancer, the clinical utility of doxorubicin is hampered by its age-related and dose-dependent cardiotoxicity.
Ashour, M.E., Atteya, R., El-Khamisy, S.F., Farag, M.A., Ibrahim, E.E.   +4 more
core   +1 more source

Genome-wide identification and expression analysis of TCP family genes in Catharanthus roseus

Frontiers in Plant Science, 2023
IntroductionThe anti-tumor vindoline and catharanthine alkaloids are naturally existed in Catharanthus roseus (C. roseus), an ornamental plant in many tropical countries.
Juan Hao, Juan Hao, Lijun Zheng, Lijun Zheng, Yidie Han, Yidie Han, Hongshan Zhang, Hongshan Zhang, Hongshan Zhang, Kailin Hou, Kailin Hou, Xueshuang Liang, Xueshuang Liang, Cheng Chen, Zhijing Wang, Jiayi Qian, Jiayi Qian, Zhihao Lin, Zhihao Lin, Zitong Wang, Houqing Zeng, Houqing Zeng, Chenjia Shen, Chenjia Shen, Chenjia Shen   +24 more
doaj   +1 more source

Plant Genetic Engineering: Technological Pathways, Application Scenarios, and Future Directions

Advanced Science, EarlyView.
This review maps the fast‐evolving landscape of plant genetic engineering, linking enabling platforms with trait‐focused applications in architecture optimization, stress resilience, yield improvement, and quality enhancement. It highlights how genome editing, transgenic strategies, and emerging multi‐gene approaches reshape breeding pipelines, while ...
Peilin Wang, Wenzhi Wang, Dongjiao Wang, Qibin Wu, Youxiong Que   +4 more
wiley   +1 more source

Review of abiotic and biotic elicitors’ roles in secondary metabolites biosynthesis of periwinkle (Catharanthus roseus (Linn.) G. Don)

Journal of Medicinal Plants, 2020
Background: Based on recent statistical survey, the cancer is the third important factor in Iran mortality. Vinblastine and vincristine alkaloids are dominantly biosynthesized in the aerial parts of periwinkle, broadly applied for cancer treatment ...
Saleh Amiri, Reza Fotovat, Bahman Panahi, Alireza Tarinezhad, Seyyed Abolghasem Mohammadi   +4 more
doaj  

Artemisinic Acid Serves as a Novel Inducer to Enhance Biosynthesis of Terpenoid Indole Alkaloids in Cambial Meristematic Cells

Natural Product Communications, 2016
To investigate the effect of artemisinic acid (AA) on improving the production of terpenoid indole alkaloids (TIAs) of Catharanthus roseus cambial meristematic cells (CMCs), feeding AA to C.
Mingxuan Wang, Jiachen Zi, Jianhua Zhu, Shan Chen, Pu Wang, Liyan Song, Rongmin Yu   +6 more
doaj   +1 more source

Agrobacterium-mediated transformation of the terpenoid indole alkaloid-producing plant species Tabernaemontana pandacaqui [PDF]

Plant Cell Reports, 1997
Plants of the Apocynaceae family produce a wide range of terpenoid indole alkaloids (TIAs) which have important pharmaceutical applications. Studies of the molecular mechanisms controlling TIA biosynthesis may eventually provide possibilities to improve product yield by genetic modification of plants or cell cultures. However, these studies suffer from
Cardoso, M.I. Lopes, Meijer, A.H., Hoge, J.H.C.   +2 more
openaire   +3 more sources

Transcriptome analysis of Catharanthus roseus for gene discovery and expression profiling. [PDF]

PLoS ONE, 2014
The medicinal plant, Catharanthus roseus, accumulates wide range of terpenoid indole alkaloids, which are well documented therapeutic agents. In this study, deep transcriptome sequencing of C.
Mohit Verma, Rajesh Ghangal, Raghvendra Sharma, Alok K Sinha, Mukesh Jain   +4 more
doaj   +1 more source

Beyond Gut Modulation: A Critical Review of the Therapeutic Potential, Safety, and Clinical Prospects of Natural Polysaccharides for IBD

Food Safety and Health, EarlyView.
In this review, we critically summarized the application of natural polysaccharides (NPs) for the treatment of IBD. This approach combines, in a unique way (right), the basic structure–activity relationships of NPs from different origins (left) with their multipronged mode of action, which involves modulation of the gut microbiota and other ...
Felix Danso, A. M. Abd El‐Aty, Kwaku Amoah, Xianghong Ju   +3 more
wiley   +1 more source

A Novel AP2/ERF Transcription Factor CR1 Regulates the Accumulation of Vindoline and Serpentine in Catharanthus roseus

Frontiers in Plant Science, 2017
As one type of the most important alkaloids in the world, terpenoid indole alkaloids (TIAs) show a wide range of pharmaceutical activities that are beneficial for clinical treatments.
Jiaqi Liu, Fangyuan Gao, Juansheng Ren, Xianjun Lu, Guangjun Ren, Rui Wang   +5 more
doaj   +1 more source

Alkaloids from marine ascidians [PDF]

, 2011
About 300 alkaloid structures isolated from marine ascidians are discussed in term of their occurrence, structural type and reported pharmacol. activity.
FATTORUSSO, ERNESTO, IMPERATORE, CONCETTA, MENNA, MARIALUISA   +2 more
core   +3 more sources