Results 41 to 50 of about 134,369 (196)

Transcriptome analysis in Catharanthus roseus leaves and roots for comparative terpenoid indole alkaloid profiles [PDF]

Journal of Experimental Botany, 2006
In Catharanthus roseus (L.) G. Don each tissue is known to produce a distinct spectrum of terpenoid indole alkaloids. Since the invaluable antineoplastic bisindole alkaloids are restricted to the aerial parts of the plant and do not occur in its underground tissues, identification of the structural and regulatory factors operating distinctly in the ...
Ashutosh K, Shukla, Ajit K, Shasany, Madan M, Gupta, Suman P S, Khanuja   +3 more
openaire   +2 more sources

Investigação fitoquímica e biológica da espécie: Esenbeckia leiocarpa Engl. [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas. Programa de Pós-Graduação em Química.A investigação fitoquímica biomonitorada das cascas da espécie Esenbeckia leiocarpa confirmou a presença de ...
Horst, Heros
core  

Role of Polyethylene Glycol in production of Anticancer Alkaloids Vincristine, Vinblastine, and Vindoline in Catharanthus roseus via Callus Culture

Kufa Journal for Agricultural Sciences
Periwinkle Cathranthus roseus  is an ornamental plant that produces over 200 alkaloids, including vincristine, vinblastine, and vindoline, which are used to treat various types of cancer.
Zainab Abdulwahid, Abdulminam Hussien Ali Al-Musawi, Abdullah Hamad Lafta   +2 more
doaj   +1 more source

Transcriptome analysis of Catharanthus roseus for gene discovery and expression profiling. [PDF]

PLoS ONE, 2014
The medicinal plant, Catharanthus roseus, accumulates wide range of terpenoid indole alkaloids, which are well documented therapeutic agents. In this study, deep transcriptome sequencing of C.
Mohit Verma, Rajesh Ghangal, Raghvendra Sharma, Alok K Sinha, Mukesh Jain   +4 more
doaj   +1 more source

The ORCA2 transcription factor plays a key role in regulation of the terpenoid indole alkaloid pathway [PDF]

BMC Plant Biology, 2013
Abstract Background The terpenoid indole alkaloid (TIA) pathway leads to the production of pharmaceutically important drugs, such as the anticancer compounds vinblastine and vincristine. Unfortunately, these drugs are produced in trace amounts, causing them to be very costly.
Li, Chun, Leopold, Alex, Sander, Guy, Shanks, Jacqueline, Zhao, Le, Gibson, Susan   +5 more
openaire   +3 more sources

Harnessing the power of natural alkaloids: the emergent role in epilepsy therapy

Frontiers in Pharmacology
The quest for effective epilepsy treatments has spotlighted natural alkaloids due to their broad neuropharmacological effects. This review provides a comprehensive analysis of the antiseizure properties of various natural compounds, with an emphasis on ...
Siyu Li, Xinyu Lin, Lijuan Duan
doaj   +1 more source

Effects of PEG-induced drought stress on regulation of indole alkaloid biosynthesis in Catharanthus roseus

Journal of Plant Interactions, 2017
Catharanthus roseus (C. roseus) plants were used to investigate the terpenoid indole alkaloids (TIAs) accumulation under the condition of PEG-induced drought stress.
Ying Liu, Qinghuan Meng, Xihua Duan, Zhonghua Zhang, Dewen Li   +4 more
doaj   +1 more source

Methyljasmonate Elicitation Increases Terpenoid Indole Alkaloid Accumulation in Rhazya stricta Hairy Root Cultures

Plants, 2019
Methyl jasmonate is capable of initiating or improving the biosynthesis of secondary metabolites in plants and therefore has opened up a concept for the biosynthesis of valuable constituents.
Amir Akhgari, Into Laakso, Hannu Maaheimo, Young Hae Choi, Tuulikki Seppänen-Laakso, Kirsi-Marja Oksman-Caldentey, Heiko Rischer   +6 more
doaj   +1 more source

Marine Indole Alkaloids—Isolation, Structure and Bioactivities

, 2021
Indole alkaloids are heterocyclic natural products with extensive pharmacological activities. As an important source of lead compounds, many clinical drugs have been derived from natural indole compounds.
Siling Chen, Fang Yang, Yong Hu, Shuai Dong   +3 more
core   +1 more source

Peroxidase and the biosynthesis of terpenoid indole alkaloids in the medicinal plant Catharanthus roseus (L.) G. Don

, 2020
The leaves of Catharanthus roseus (L.) G. Don produce the first natural drugs used in cancer therapy – the dimeric terpenoid indole alkaloids vinblastine and vincristine. The study of C. roseus further revealed two other terpenoid indole alkaloids with
Ros Barceló, A., Pereira, L.G., Sottomayor, M., Cardoso, Inês Lopes   +3 more
core   +1 more source