Results 51 to 60 of about 4,886 (206)

Phytochemicals in MASLD: A Focused Review of Gut Microbiome‐Linked Mechanisms

Phytotherapy Research, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as a major global health burden, yet effective pharmacological options remain limited. Recent advances highlight the gut microbiome as a key modulator of liver metabolism, inflammation, and fibrosis, making it a promising therapeutic target.
Jeong In Seo, Su Min Kim, Hye Hyun Yoo
wiley   +1 more source

Gene-to-metabolite networks for terpenoid indole alkaloid biosynthesis in Catharanthus roseus cells [PDF]

Proceedings of the National Academy of Sciences, 2006
Rational engineering of complicated metabolic networks involved in the production of biologically active plant compounds has been greatly impeded by our poor understanding of the regulatory and metabolic pathways underlying the biosynthesis of these compounds.
Oresic, Matej, Seppänen-Laakso, Tuulikki, Katajamaa, Mikko, Lammertyn, Freya, Ardiles-Diaz, Wilson, Van Montagu, Marc C. E., Inzé, Dirk, Oksman-Caldentey, Kirsi-Marja, Goossens, Alain, Rischer, Heiko   +10 more
openaire   +4 more sources

Pangenome analysis reveals the genetic mechanism underlying high‐altitude adaptation in Qinghai–Xizang (Tibet) Plateau Rhododendron

Journal of Integrative Plant Biology, EarlyView.
Pan‐genome analysis reveals that high‐altitude Rhododendron species resist alpine cold stress by rapidly sensing and engaging the chilling response pathway and genes that directly and indirectly protect the plant from UV radiation. Heritable genomic features such as long terminal repeats contribute to the adaptive diversification of Rhododendron ...
Haoyang Zhou, Zhongping Xu, Fanhuang Zeng, Haiyu Sang, Zhenhua Liu, Miao Sun, Qiang Fu, Kaige Zhao, Daming Tan, Manzhu Bao, Shuangxia Jin, Xiuqun Liu   +11 more
wiley   +1 more source

Role of Polyethylene Glycol in production of Anticancer Alkaloids Vincristine, Vinblastine, and Vindoline in Catharanthus roseus via Callus Culture

Kufa Journal for Agricultural Sciences
Periwinkle Cathranthus roseus  is an ornamental plant that produces over 200 alkaloids, including vincristine, vinblastine, and vindoline, which are used to treat various types of cancer.
Zainab Abdulwahid, Abdulminam Hussien Ali Al-Musawi, Abdullah Hamad Lafta   +2 more
doaj   +1 more source

Catalytic enantioselective synthesis of quaternary carbon stereocentres. [PDF]

, 2014
Quaternary carbon stereocentres-carbon atoms to which four distinct carbon substituents are attached-are common features of molecules found in nature. However, before recent advances in chemical catalysis, there were few methods of constructing single ...
Overman, Larry E, Quasdorf, Kyle W
core  

Inhibition of jasmonic acid‐isoleucine conjugating enzyme JAR1 shifts the local and systemic leaf signals and metabolic profiles in Arabidopsis

New Phytologist, EarlyView.
Summary Jasmonates (JAs)‐mediated pathways are central signaling hubs in plant defense responses. However, the identification of mobile and nonmobile signals involved in downstream systemic signaling is still less studied. Here, we investigate the role of the jasmonic acid‐isoleucine (JA‐Ile) conjugating enzyme, JAR1, in shifting wound‐induced local ...
Ming Zeng, Axel Mithöfer
wiley   +1 more source

Harnessing the power of natural alkaloids: the emergent role in epilepsy therapy

Frontiers in Pharmacology
The quest for effective epilepsy treatments has spotlighted natural alkaloids due to their broad neuropharmacological effects. This review provides a comprehensive analysis of the antiseizure properties of various natural compounds, with an emphasis on ...
Siyu Li, Xinyu Lin, Lijuan Duan
doaj   +1 more source

Effects of PEG-induced drought stress on regulation of indole alkaloid biosynthesis in Catharanthus roseus

Journal of Plant Interactions, 2017
Catharanthus roseus (C. roseus) plants were used to investigate the terpenoid indole alkaloids (TIAs) accumulation under the condition of PEG-induced drought stress.
Ying Liu, Qinghuan Meng, Xihua Duan, Zhonghua Zhang, Dewen Li   +4 more
doaj   +1 more source

Bioactive Marine Drugs and Marine Biomaterials for Brain Diseases [PDF]

, 2014
Marine invertebrates produce a plethora of bioactive compounds, which serve as inspiration for marine biotechnology, particularly in drug discovery programs and biomaterials development.
Andrade, Paula B., Ferreres, Federico, Grosso, Clara, Valentão, Patricia   +3 more
core   +2 more sources

Transcriptional Regulation of the Novel Theacrine Synthase Gene CsTcS2 by the CsTINY–CsWRKY33 Module Underpins Theacrine Biosynthesis in Camellia sinensis

Plant Biotechnology Journal, EarlyView.
ABSTRACT Theacrine (1,3,7,9‐tetramethyluric acid) is a purine alkaloid detected in multiple wild and specialised tea germplasms (Camellia sinensis) from South China, including Kucha. However, the molecular mechanisms governing its biosynthesis remain poorly understood. Here, we identify CsTcS2 as a novel theacrine synthase in tea plant.
Ting Wu, Lihua Zhu, Chenyu Shao, Siyi Xie, Na Li, Xinyu Li, Fang Wang, Lvwen Peng, Huiying Jin, Fanghuizi Shang, Jianan Huang, Zhonghua Liu, Na Tian, Shuoqian Liu   +13 more
wiley   +1 more source