Results 171 to 180 of about 2,755,275 (260)

First‐in‐human, phase I, randomized, safety, pharmacokinetic, food‐effect and pharmacodynamic study of a tyrosine kinase 2/Janus kinase 1 inhibitor, SDC‐1801

British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3513-3526, October 2026.
Aim The purpose of this study is to evaluate safety, tolerability, pharmacokinetics (PK), food‐effect (FE) and pharmacodynamics (PD) of an oral tyrosine kinase‐2 (TYK2)/Janus kinase‐1 (JAK1) inhibitor, SDC‐1801, in healthy adult participants. Methods This first‐in‐human study randomized 95 male and female participants.
Chris Brearley, Sam Francis, John Reader, Judi Proctor   +3 more
wiley   +1 more source

Full-length transcriptome sequencing analysis and characterization of MADS-box genes in Rhododendron fortunei. [PDF]

BMC Plant Biol
Wang J, Lou X, Huang H, Lin E.
europepmc   +1 more source

Environmental Drivers of Metabolic Plasticity in Rubia cordifolia From the Western Himalaya: Implications for Phytochemical Diversity and Antioxidant Potential

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Environmental heterogeneity drives remarkable metabolic plasticity in Rubia cordifolia with significant variation in nutritional constituents, phytochemicals, bioactive compounds, and antioxidant activity among natural populations. High‐altitude populations exhibited higher accumulation of phenolics, flavonoids, alizarin, mollugin, and antioxidant ...
Deepti Tiwari, Sandeep Rawat, Veena Pandey, Vinod C. Joshi, Indra D. Bhatt, R. C. Sundriyal   +5 more
wiley   +1 more source

Functional divergence of MADS-box genes and the dual regulatory role of a long noncoding RNA underlie sex determination in Ginkgo biloba. [PDF]

BMC Plant Biol
Wu H, Zheng B, Liu K, Yin T, Wei S.
europepmc   +1 more source

Interaction of two MADS-box genes leads to growth phenotype divergence of all-flesh type of tomatoes. [PDF]

Nat Commun, 2021
Huang B, Hu G, Wang K, Frasse P, Maza E, Djari A, Deng W, Pirrello J, Burlat V, Pons C, Granell A, Li Z, van der Rest B, Bouzayen M.   +13 more
europepmc   +1 more source

Macrophage lipid efflux regulates the tumour microenvironment in early‐stage lung adenocarcinoma

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
1. Macrophages undergo metabolic rewiring even during early tumourigenesis. 2. Main alterations of macrophages are conserved between human and mice in early‐stage lung adenocarcinoma. 3. Tumour‐associated macrophages are characterised by enhanced lipid efflux 4.
Yujie Zheng, Yuan Wang, Yalin Wang, Yue Shi, Hui Kong, Shaohua Lu, Yong Zhang, Jie Hu, Jian Zhou, Xiangdong Wang, Meng Xiang, Qiong Liu, Hongyi Xin, Charles A. Powell, Fred R. Hirsch, Chunxue Bai, Yuanlin Song, Jun Yin, Dawei Yang   +18 more
wiley   +1 more source

Integrated Phylogenomic and Expression Analyses Reveal Lineage-Specific Loss of the Mβ Subfamily and Regulatory Diversification of MADS-Box Genes in Pepper. [PDF]

Plants (Basel)
Zhu J, Meng S, Liu J, Zhang T, Cheng Y, Ruan M, Ye Q, Wang R, Yao Z, Zhou G, Li Z, Liu C, Wan H.   +12 more
europepmc   +1 more source

Genome-Wide Analyses of MADS-Box Genes in Humulus lupulus L. Reveal Potential Participation in Plant Development, Floral Architecture, and Lupulin Gland Metabolism. [PDF]

Plants (Basel), 2022
Márquez Gutiérrez R, Cherubino Ribeiro TH, de Oliveira RR, Benedito VA, Chalfun-Junior A.   +4 more
europepmc   +1 more source

USP25 stabilises GLI1 through K48‐linked deubiquitination within a reciprocal regulatory circuit in osteoarthritis models

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
GLI1‐centred USP25‐GLI1 reciprocal regulation in OA‐relevant models. Hedgehog/GLI1 signalling transcriptionally reinforces USP25 expression, while USP25 deubiquitinates and stabilises GLI1. This reciprocal circuit is associated with inflammatory and cartilage‐catabolic changes in the tested models.
Qian Zhang, Yinyan Ye, Yijie Huang, Jun Li, Dongfeng Huang   +4 more
wiley   +1 more source

Tandem MADS-Box Genes FUL2 and MADS1 Form a Regulatory Module to Repress Serotonin Biosynthesis via Direct ASMT5 Activation in Tomato Fruit. [PDF]

Plant Biotechnol J
Xu Y, Jia H, Tang D, Zhang L, Liu X, Rong J, Lv Y, Lang Z, Niu Q.   +8 more
europepmc   +1 more source