Results 191 to 200 of about 2,755,275 (260)

Fraxinus excelsior updated long-read genome reveals the importance of MADS-box genes in tolerance mechanisms against ash dieback. [PDF]

open access: yesG3 (Bethesda)
Franco Ortega S   +8 more
europepmc   +1 more source

Optical genome mapping enhanced by refined variant interpretation in pediatric acute lymphoblastic leukemia

open access: yesThe Journal of Pathology, Volume 270, Issue 2, Page 241-254, October 2026.
Abstract Reliable detection of structural variants (SVs) and copy number variations (CNVs) is crucial in the contemporary diagnostics of pediatric B‐cell acute lymphoblastic leukemia (B‐ALL). However, limitations of commonly used conventional and molecular cytogenetic methods may hinder the accurate genetic characterization of patients.
Anna Bekő   +21 more
wiley   +1 more source

Graft Biology in the CRISPR Era: From Tissue Fusion to Genome Compatibility

open access: yesPlant-Environment Interactions, Volume 7, Issue 5, October 2026.
ABSTRACT Plant lineage has traditionally constrained grafting compatibility, with monocots generally considered incompatible because of their dispersed vascular bundles and limited secondary growth. Recent studies have shown that embryonic grafting can establish successful graft unions in selected monocot systems by exploiting early developmental ...
Melagani Subash Chandra Gowda Sahaja   +5 more
wiley   +1 more source

Influence of 3D Printing Parameters on ULTEM 9085 Mechanical Properties Using Explainable Machine Learning

open access: yesSPE Polymers, Volume 7, Issue 4, October 2026.
An explainable machine‐learning framework predicts complete stress–strain behavior and key mechanical properties of FFF‐printed ULTEM 9085 from four printing parameters. Extra Trees delivered the most accurate and stable predictions, while SHAP and LIME clarified how each parameter influences material performance.
Md Asif Hasan   +7 more
wiley   +1 more source

Application of an Open‐Source Modular Framework for Pharmacokinetic, Pharmacodynamic, and Safety Simulations to Anti‐Tuberculosis Drugs

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 10, October 2026.
ABSTRACT Tuberculosis (TB) treatment requires long‐term multidrug regimens where dosing, efficacy, and safety optimization remain challenging. This tutorial establishes an integrated, open‐source, modular framework connecting high‐throughput PBPK (HT‐PBPK) simulations, mechanistic PBPK models, pharmacodynamic endpoints, and safety predictions for anti ...
Marco Siccardi   +9 more
wiley   +1 more source

Male production in green sea turtles under a feminizing climate: A validated model of sex ratios with temperature‐dependent sex determination

open access: yesJournal of Animal Ecology, Volume 95, Issue 10, Page 2119-2132, October 2026.
This study introduces validated methods to predict sex ratios in wild Green sea turtle (Chelonia mydas) nests. It quantifies beach‐scale temperature heterogeneity, incorporates clutch‐level variation in thermal sensitivity and models temperature effects across the thermosensitive period, demonstrating how temporal temperature dynamics and spatial ...
Marc Girondot   +3 more
wiley   +1 more source

Impaired Hepatic Glucose Metabolism Is Associated With Glucose Intolerance in Mice Carrying α2 Isoform Na,K‐ATPase Mutation

open access: yesActa Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Aim The Na,K‐ATPase is important for energy demanding cellular processes, including essential components of substrate metabolism and metabolic flexibility. Mice heterozygous for the hemiplegic migraine‐related mutation, G301R, of the Na,K‐ATPase α2 isoform (α2+/G301R) demonstrated altered metabolism in the heart.
Christian Staehr   +11 more
wiley   +1 more source

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