Results 51 to 60 of about 6,176 (260)
Educação (Santa Maria. Online), 2012 The paper presents a State of the Art regarding the research project “the efficacy and the quality of skill acquisition in rural education: is this model transferable to different types of schools?” (EDU2009-13460, Subprograma EDUC).
Laura Domingo +2 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Investigaciones Geográficas, 2012 En este documento se exponen los conceptos básicos que ayudan a entender otra forma de gestionar la Zona Metropolitana del Valle de México (ZMVM). Con el objetivo de descifrar el comportamiento de los agentes que intervienen en la ZMVM se abordan los ...
Jesús Rodríguez Rodríguez +1 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Asparkía, 2004 Resumen Intentar comprender las situaciones que las mujeres, jóvenes y más mayores, procedentes de las migraciones turcas y magrebíes viven en Francia al inicio del siglo XXI, implica plantearse la cuestión en el campo del amplio movimiento migratorio ...
Alain Montaclair
doaj
Desafíos para la inclusión en el aula
Acción y Reflexión EducativaEsta investigación tiene la intención de identificar cuáles son los desafíos a los que se enfrentaron los docentes en formación, para desarrollar una práctica inclusiva dentro del aula, durante sus prácticas profesionales.
Sergio Hugo Hernández Belmonte
doaj +1 more source
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
La autonomía curricular en la Nueva Escuela Mexicana
Acción y Reflexión EducativaEste texto tiene el propósito de reflexionar en torno al papel de la autonomía curricular como un parteaguas para iniciar un proceso de resignificación del docente de Educación Primaria.
Sergio Hugo Hernández Belmonte
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source