Results 61 to 70 of about 6,213 (261)
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Revista Electrónica en Educación y PedagogíaEsta investigación, de tipo cuanti-cualitativo, partió de la integración de las neuro-ciencias en la formación docente con la finalidad de aplicar conceptos que explican la cogni-ción, distinguir diferencias y propiciar la maduración de ...
José Antonio Guerrero- García +1 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Anuario Mexicano de Historia de la EducaciónAl referirnos a la enseñanza de la historia a menudo se habla de una enseñanza memorística de fechas, batallas y personajes importantes, y del dictado, la copia y la memorización pasiva de textos. Una fuente de tales aseveraciones han sido los programas
Rocío Ramírez González
doaj +1 more source
La Educación y el Aporte de las Normales en Nariño
Estudios Latinoamericanos, 2015 Las normales en Nariño han cumplido un gran papel en cuanto a la formación de los futuros maestros, quienes a través de la práctica pedagógica han formado los cimientos de una educación que ha contribuido con el seguimiento en valores de las nuevas ...
José Oliden Muñoz Bravo
doaj +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Intelligent Assistant with Artificial Intelligence for Language Learning
Applied SciencesAn intelligent assistant with artificial intelligence (AI) for language learning was developed. A dynamic user interface and a supervised feedback module using web technologies (HTML5, CSS3, and JavaScript ES6+) and Python v3.9 for supporting language ...
Diego De-La-Cruz-Salcedo +4 more
doaj +1 more source