Results 31 to 40 of about 23,787 (266)

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Progress in toroidal magnetic confinement

Le Journal de Physique Colloques, 1979
This paper will discuss the confinement properties of plasma in magnetic fields which are characterized by their strong toroidal components. In such systems confinement is achieved by the addition of poloidal magnetic fields which are either produced internally by toroidal currents induced in the plasma - internal confinement - or by currents flowing ...
openaire   +3 more sources

Tailoring magnetic skyrmions by geometric confinement of magnetic structures [PDF]

Applied Physics Letters, 2017
Nanoscale magnetic skyrmions have interesting static and transport properties that make them candidates for future spintronic devices. Control and manipulation of the size and behavior of skyrmions is thus of crucial importance. Using a Ginzburg-Landau approach, we show theoretically that skyrmions and skyrmion lattices can be stabilized by a spatial ...
Steven S.-L. Zhang, C. Phatak, A. K. Petford-Long, O. G. Heinonen   +3 more
openaire   +2 more sources

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Refining light impurity content estimates at the lower divertor based on experimental data in WEST

Nuclear Materials and Energy, 2023
WEST is an actively cooled, long-pulse tokamak with nearly all plasma-facing components (PFC) made of tungsten (W). One of the aims of WEST is to study plasma operation with W PFCs in preparation for long-pulse operation on W divertor devices like ITER ...
A. Grosjean, D.C. Donovan, C.A. Johnson, J.P. Gunn, C. Guillemaut, N. Fedorczak, C.C. Klepper, E.A. Unterberg   +7 more
doaj   +1 more source

Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling

FEBS Open Bio, EarlyView.
Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt, Annika Winbo, Jenny Malmström   +2 more
wiley   +1 more source

Experimental and numerical modeling of plasma start-up assisted by electron drift injection on J-TEXT

Nuclear Fusion, 2023
Start-up is one of the critical phases for tokamak discharge. The electron drift injection (EDI) system has been developed on J-TEXT for start-up studies.
Junli Zhang, Zhifeng Cheng, Yanli Peng, Zhoujun Yang, Kazunobu Nagasaki, Nengchao Wang, Hao Cai, Yonghua Ding, Zhipeng Chen, Zhongyong Chen, Wei Jiang, Donghui Xia, Zhijiang Wang, Yuan Pan, J-TEXT team   +14 more
doaj   +1 more source

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe, Keizo Sugaya, Kentaro Hayashi, Keiko Hino, Yasuhiro Nakata, Kota Bokuda, Toshio Shimizu, Kazushi Takahashi   +7 more
wiley   +1 more source

Dividing and setting strategy of improving calculation efficiency for needle electrode corona discharge with a large‐scale space

High Voltage, 2022
Needle electrodes are widely used in the research of corona discharge. Aiming at the problem of needle electrode discharge in a large‐scale space (tens or even hundreds of centimetres), a hybrid model was proposed in the previous work.
Dingchen Li, Chuan Li, Jiawei Li, Pengyu Wang, Zhi Liu, Wendi Yang, Ming Zhang, Yong Yang, Kexun Yu   +8 more
doaj   +1 more source