Results 51 to 60 of about 32,943 (309)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Plasma heat load in the toroidal gaps of the ITER-like plasma facing units in WEST tokamak

Nuclear Materials and Energy
The heat load deposited in the toroidal gaps between two tungsten monoblocks remains an open problem to prepare safe and powerful experiments in ITER.
Q. Tichit, M.H. Aumeunier, Y. Corre, R. Dejarnac, L. Dubus, J. Gaspar, J. Gerardin, A. Grosjean, J.P. Gunn, A. Juven, K. Krieger, A. Podolník, E. Tsitrone   +12 more
doaj   +1 more source

Tailoring magnetic skyrmions by geometric confinement of magnetic structures [PDF]

Applied Physics Letters, 2017
Nanoscale magnetic skyrmions have interesting static and transport properties that make them candidates for future spintronic devices. Control and manipulation of the size and behavior of skyrmions is thus of crucial importance. Using a Ginzburg-Landau approach, we show theoretically that skyrmions and skyrmion lattices can be stabilized by a spatial ...
Steven S.-L. Zhang, C. Phatak, A. K. Petford-Long, O. G. Heinonen   +3 more
openaire   +2 more sources

Tilting instability of magnetically confined spheromaks [PDF]

Journal of Plasma Physics, 2020
We consider the tilting instability of a magnetically confined spheromak using three-dimensional magnetohydrodynamic and relativistic particle-in-cell calculations with an application to astrophysical plasmas, specifically those occurring in magnetar magnetospheres.
Riddhi Mehta, Maxim Barkov, Lorenzo Sironi, Maxim Lyutikov   +3 more
openaire   +2 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source

Feasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick, Nomin Enkhtsetseg, Joseph Sadok, Matheus Mochetti, Annabel Sorby Adams, Jennifer Guo, Cristina Trapaga Hacker, Isabella Gomez Hjerthen, Seungwon Lee, Siddharth Satish, Andrew S. Ham, Justin Hill, Denis Balaban, Kevin Kyle, Rebecca L. Gillani, Marcelo Matiello, Aleksandar Videnovic, Eric C. Klawiter, W. Taylor Kimberly, Farrah J. Mateen   +19 more
wiley   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

Magnetic confinement of effectively unmagnetized plasma particles

, 2020
Article develops a planar model for an artificially structured boundary that may provide magnetic confinement of nonmagnetically trapped plasma ...
Ordonez, Carlos A., C. A. Ordonez
core   +1 more source

Understanding the spectrum during the tearing mode locking by rotating RMP in J-TEXT

AIP Advances, 2022
The rotating resonant magnetic perturbation (RMP) could lock the tearing mode (TM) and prevent disruption. It is found that the TM instantaneous frequency oscillates during TM locking on the RMP.
Da Li, Mao Li, Yonghua Ding, Nengchao Wang, Bo Rao, Ying He, Feiyue Mao, Chengshuo Shen, Ruo Jia, Song Zhou, Zhengkang Ren, Chuanxu Zhao, Abba Alhaji Bala, Zhipeng Chen, Zhongyong Chen, Zhoujun Yang, Lin Yi, Kexun Yu, J-TEXT Team   +18 more
doaj   +1 more source