Results 171 to 180 of about 7,982 (306)

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Revealing the transient ionization dynamics and mode-coupling mechanisms of helicon discharge through a self-consistent multiphysics model. [PDF]

Sci Rep
Ma JJ, Chang L, Wu MY, Zhou H, Zhang YW, Zadiriev I, Kralkina E, Isayama S, You SJ.   +8 more
europepmc   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Accessing the density-free regime with ECRH-assisted ohmic start-up on EAST. [PDF]

Sci Adv
Liu J, Zhu P, Escande DF, Liu W, Xue S, Lin X, Tang P, Wang L, Yan N, Yang J, Duan Y, Jia K, Wu Z, Cheng Y, Zhang L, Qian J, Ding R, Zhou R, EAST team.   +18 more
europepmc   +1 more source

Phase Diagrams and Piezoelectric Properties of Wurtzite Al1−x−yScxGdyN Heterostructural Alloys

Advanced Science, EarlyView.
This study demonstrates ferroelectricity and piezoelectric properties improvement of quaternary wurtzite Al1−x−yScxGdyN${\rm Al}_{1-x-y}{\rm Sc}_x{\rm Gd}_y{\rm N}$ films, guided by density functional theory calculations. Wurtzite Al1−x−yScxGdyN${\rm Al}_{1-x-y}{\rm Sc}_x{\rm Gd}_y{\rm N}$ films have a high optical bandgap, enhanced piezoelectric ...
Julia L. Martin, Cheng‐Wei Lee, Nate S.P. Bernstein, Thi Nguyen, Ande Bryan, Eli Cooper, John S. Mangum, Sage R. Bauers, Andriy Zakutayev, Keisuke Yazawa, Prashun Gorai, Rebecca W. Smaha   +11 more
wiley   +1 more source

Understanding Large-Scale Plasma Simulation Challenges for Fusion Energy on Supercomputers

Understanding plasma instabilities is essential for achieving sustainable fusion energy, with large-scale plasma simulations playing a crucial role in both the design and development of next-generation fusion energy devices and the modelling of ...
Williams, Jeremy J.,, Hromadka, Jakub,, Laure, Erwin,, Bhole, Ashish,, Hoelzl, Matthias,, Podolnik, Ales,, Kos, Leon,, Team, JOREK, Kierans, Dylan,, Tang, Weikang,, Tskhakaya, David,, Holod, Ihor,, Markidis, Stefano,, Costea, Stefan,   +13 more
core  

Double 3 MJ dense plasma focus for thermonuclear drive inertial confinement fusion. [PDF]

Sci Rep
Kiai SMS, Adlparvar S, Sadeghi H, Fazelpour S.   +3 more
europepmc   +1 more source

Atomic Tuning of Metal‐Support Interactions for Pathway‐Selective CO2 Photoreduction on TiO2

Advanced Science, EarlyView.
Single‐atom Fe and Cu catalysts anchored on TiO2 steer photocatalytic CO2 reduction toward distinct pathways. Fe sites favor rapid *CO desorption and selective CO formation, whereas Cu sites stabilize *CHO intermediates, enabling deep reduction and C─C coupling. Combined spectroscopy and DFT calculations reveal how metal–support interactions and oxygen
Dongyun Kim, Wonjae Ko, Byoung‐Hoon Lee, Sanghoon Kim, Yun Do Kim, Hyunsoo Ahn, Yoon Jung, Chan Woo Lee, Kug‐Seung Lee, Eunhee Gong, Junho Lee, Minho Kim, Taeghwan Hyeon, Su‐Il In   +13 more
wiley   +1 more source

Topology-guided rotational dynamics of magnetic soliton assemblies under pulsed current. [PDF]

Nat Commun
Li Z, Koshibae W, Karube K, Taguchi Y, Tokura Y, Nagaosa N, Yu X.   +6 more
europepmc   +1 more source

Possible Improvements for Magnetic Confinement Fusion

Magnetic-confinement fusion has traditionally been pursued through higher temperature and improved containment geometry, assuming the Coulomb barrier between nuclei to be isotropic. Recent work (R30–R46) re-examines this assumption by modeling nucleons and nuclei as structured four-dimensional rotors with internal mass–charge planes (θ_eff, Δφ₄ ...
openaire   +2 more sources