Results 91 to 100 of about 5,309,234 (282)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

Medication Administration Errors and Associated Factors Among Nurses

open access: yesInternational Journal of General Medicine, 2020
Dejene Tsegaye,1 Girma Alem,1 Zenaw Tessema,2 Wubet Alebachew3 1Department of Nursing, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia; 2Department of Pharmacy, College of Health Sciences, Debre Markos University, Debre Markos,
Tsegaye D   +3 more
doaj  

ABOUT A POSSIBLE CONNECTION BETWEEN EARTHQUAKES AND LUNAR-SOLAR GRAVITY VARIATIONS

open access: yesИзвестия высших учебных заведений: Геология и разведка, 2018
A possible correlation between the destructive earthquakes of magnitude M = 7 and above and luni-solar gravity variations between 1975 and 2015 has been analyzed.
Yu. V. Antonov
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Comparative Analysis Of Accelerometer Sensor And Piezoelectric Sensor Capabilities In The Early Warning System Earthquake Disaster

open access: yesJournal of Electrical Engineering and Computer
An earthquake is a vibration or shock caused by a sudden release of energy from within the earth, which produces seismic waves. The Indonesian region is currently vulnerable to volcanic and tectonic earthquakes due to the Pacific Ring of Fire, where the ...
Yoses Manuel   +2 more
doaj   +1 more source

MATHEMATICAL MODEL FOR CALCULATING ENERGY CLASS, INTENSITY AND MAGNITUDE OF THE EARTHQUAKE REAL TIME

open access: yesВестник Дагестанского государственного технического университета: Технические науки, 2016
The mathematical dependence, allowing a nomogram based on T.G. Rautian calculates real-time energy class, magnitude and intensity of earthquakes.
G. K. Aslanov   +3 more
doaj   +1 more source

Abnormal low-magnitude seismicity preceding large-magnitude earthquakes

open access: yesNature Communications
Unraveling the precursory signals of potentially destructive earthquakes is crucial to understand the Earth's crust dynamics and to provide reliable seismic warnings. Earthquake precursors are ambiguous, but recent experimental studies suggest that robust warning signs may precede large seismic events in the short (day-to-months) term.
Társilo Girona, Kyriaki Drymoni
openaire   +3 more sources

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

Period-magnitude relations for M giants in Baade's Window NGC6522

open access: yes, 2003
A large and complete sample of stars with K < 9.75 in the NGC6522 Baade's Window is examined using light curves from MACHO and IJK from DENIS. All 4 of the sequences ABCD in the K vs logP diagram of the LMC are seen in the Bulge.
Alard   +33 more
core   +2 more sources

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