Results 101 to 110 of about 5,309,234 (282)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Russian economy: challenges and reaction

Путеводитель предпринимателя
The article examines and analyzes the problems and dynamics of economic growth in 2024 under the influence of external and internal factors and conditions, the dynamics of the key interest rate and inflation, and ways to reduce the volatility of the ...
L. A. Akhmetov, M. A. Bulavina
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Magnitude and associated factors of neonatal mortality among neonates admitted at Dessie comprehensive specialized hospital, Northeast, Ethiopia

Frontiers in Pediatrics
BackgroundNeonatal mortality rate is high in sub-Saharan Africa than high-income countries in relation to the growing wealth disparity. Different factors are linked with neonatal mortality in Ethiopia.
Berhanu Adugna, Robel Asaminew, Getye Solomon Maru, Haimanot Ayele Eshetie, Endris Mohammed, Ayele Samuel, Abdulmelik Mekonnnen, Nurye Fentaw, Brhanu Belay, Adem Mekonen, Mengstie Nigussie, Fekadeselassie Belege Getaneh, Alemu Gedefie   +12 more
doaj   +1 more source

Scaling relation between earthquake magnitude and the departure time from P wave similar growth

Geophysical Research Letters, 2016
We introduce a new scaling relation between earthquake magnitude (M) and a characteristic of initial P wave displacement. By examining Japanese K‐NET data averaged in bins partitioned by Mw and hypocentral distance, we demonstrate that the P wave ...
Shunta Noda, William L. Ellsworth
doaj   +1 more source

RECENT STRONG EARTHQUAKES IN CENTRAL ASIA: REGULAR TECTONOPHYSICAL FEATURES OF LOCATIONS IN THE STRUCTURE AND GEODYNAMICS OF THE LITHOSPHERE. PART 1. MAIN GEODYNAMIC FACTORS PREDETERMINING LOCATIONS OF STRONG EARTHQUAKES IN THE STRUCTURE OF THE LITHOSPHER

Геодинамика и тектонофизика, 2015
Studying locations of strong earthquakes (М≥8) in space and time in Central Asia has been among top prob-lems for many years and still remains challenging for international research teams.
S. I. Sherman, Ma Jin, E. A. Gorbunova
doaj   +1 more source

Verification of Magnitude and Phase Responses in Fixed-Point Digital Filters

, 2017
In the digital signal processing (DSP) area, one of the most important tasks is digital filter design. Currently, this procedure is performed with the aid of computational tools, which generally assume filter coefficients represented with floating-point ...
Clavier, Laurent, Cordeiro, Lucas C., de Bessa, Iury V., de Freitas, Mauro L., de Mello, Daniel P. M., Filho, Eddie B. L., Junior, Waldir S. S.   +6 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Dissecting the Spitzer color-magnitude diagrams of extreme LMC AGB stars

, 2014
We trace the full evolution of low- and intermediate-mass stars ($1 M_{\odot} \leq M \leq 8M_{\odot}$) during the Asymptotic Giant Branch (AGB) phase in the {\it Spitzer} two-color and color-magnitude diagrams.
Brocato, E., D'Antona, F., Dell'Agli, F., Di Criscienzo, M., Hernández, D. A. García, Rossi, C., Schneider, R., Ventura, P.   +7 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source