Results 61 to 70 of about 6,305,091 (339)
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
AerospaceThe aviation industry relies on continuous inspections to ensure infrastructure safety, particularly in confined spaces like aircraft fuel tanks, where human inspections are labor-intensive, risky, and expose workers to hazardous exposures.
Adrián Ricárdez Ortigosa +6 more
doaj +1 more source
Biomedicines, 2021 Mutations in the ganglioside-induced differentiation associated protein 1 (GDAP1) gene have been associated with demyelinating and axonal forms of Charcot-Marie-Tooth (CMT) disease, the most frequent hereditary peripheral neuropathy in humans.
Federica Miressi +11 more
doaj +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Capturing, classification and concept generation for automated maintenance tasks [PDF]
, 2014 Maintenance is an efficient and cost effective way to keep the function of the product available during the product lifecycle. Automating maintenance may drive down costs and improve performance time; however capturing the necessary information required ...
Farnsworth, Michael, Tomiyama, Tetsuo
core +1 more source
Fault Diagnosis of Distributed Energy Distribution Network Based on PSO-BP
EAI Endorsed Transactions on Energy WebWith the increasing scale of distribution network at distribution time, its complexity grows geometrically, and its fault diagnosis becomes more and more difficult.
Xiaokun Han +3 more
doaj +1 more source
Applied Sciences, 2023 Switches and crossings (S&Cs) are also known as turnouts or railway points. They are important assets in railway infrastructures and a defect in such a critical asset might lead to a long delay for the railway network and decrease the quality of service.
Yang Zuo +3 more
doaj +1 more source
Ustekinumab as Induction and Maintenance Therapy for Crohn's Disease.
New England Journal of Medicine, 2016 BACKGROUND Ustekinumab, a monoclonal antibody to the p40 subunit of interleukin-12 and interleukin-23, was evaluated as an intravenous induction therapy in two populations with moderately to severely active Crohn's disease. Ustekinumab was also evaluated
B. Feagan +26 more
semanticscholar +1 more source
Social context prevents heat hormetic effects against mutagens during fish development
FEBS Letters, EarlyView.This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere +5 more
wiley +1 more source