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Nature Reviews Immunology, 2019
Commensal bacteria at mucosal surfaces can remotely control the thymic maturation of mucosal-associated invariant T cells through the production of microbial factors that enter the circulation and are taken up by thymic cells.
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Commensal bacteria at mucosal surfaces can remotely control the thymic maturation of mucosal-associated invariant T cells through the production of microbial factors that enter the circulation and are taken up by thymic cells.
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MAIT cells and pathogen defense
Cellular and Molecular Life Sciences, 2014Mucosa-associated invariant T (MAIT) cells are a unique population of innate T cells that are abundant in humans. These cells possess an evolutionarily conserved invariant T cell receptor α chain restricted by the nonpolymorphic class Ib major histocompatibility (MHC) molecule, MHC class I-related protein (MR1). The recent discovery that MAIT cells are
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MAIT cells and MR1-antigen recognition
Current Opinion in Immunology, 2017Mucosal-associated invariant T cells (MAIT cells) are innate-like T cells that recognise antigens presented by the monomorphic MHC-I related molecule, MR1. Distinct from the conventional MHC-restricted T cell system, MR1 presents small-molecule precursors, derived from microbial biosynthesis of riboflavin, to activate the innate MAIT cell effector ...
Andrew N, Keller +4 more
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Charting MAIT cell development
Science, 2019T Cells Mucosal-associated invariant T (MAIT) cells are a distinct subset of T cells that recognize vitamin B metabolites presented by major histocompatibility complex class I–related protein (MR1). Koay et al. used bulk and single-cell RNA sequencing and flow cytometric analysis to characterize the development of murine and human MAIT cells.
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MAIT Cell Activation by Fungal Pathogens
2019MAIT cells can recognize and respond to several pathogens in a distinct manner. However, many studies are focused on activation by bacteria and by viruses, while reports about molds and MAIT cells are rare. Here, we describe a method to investigate MAIT cell interaction with filamentous fungi from Aspergillus and Mucorales species.
Susanne, Jahreis +2 more
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Unconventional MAIT cell responses to bacterial infections
Seminars in Immunology, 2022Mucosal Associated Invariant T cells (MAIT) exert potent antimicrobial activity through direct recognition of metabolite-MR1 complexes and indirect activation by inflammatory cytokines. Additionally, via licensing of antigen presenting cells, MAIT cells orchestrate humoral and cellular adaptive immunity. Our recent understanding of molecular mechanisms
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Fighting Liver Metastasis by Activating MAIT Cells
Cancer Immunology Research, 2021Abstract In this issue, Ruf and colleagues show that antigen stimulation of mucosal-associated invariant T (MAIT) cells in the presence of the TLR9 ligand CpG decreases intrahepatic tumor growth, suggesting that MAIT cells could be used as an antitumor tool.
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MAIT Cells in Health and Disease
2019Mucosal-associated invariant T (MAIT) cells are a newly described subset of T cells that are found in the blood and are enriched in many tissues, particularly in the liver. MAIT cells express a semi-invariant T cell receptor restricted by the MHC class I-related (MR1) molecule. MAIT cells are activated in a MR1-dependent manner in response to microbial-
Isabelle, Magalhaes +2 more
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AbstractIn humans, MAIT cells represent the most abundant T‐cell subset reacting against bacteria. MAIT cells belong to the evolutionarily conserved family of “preset” T cells that includes also NKT cells. Both subsets are selected by double positive thymocytes leading to common features such as PLZF expression.
Olivier Lantz, François Legoux
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