Results 141 to 150 of about 1,556 (163)

Selective stimulation of Ca2+ flux in cells by maitotoxin

European Journal of Pharmacology: Molecular Pharmacology, 1992
Maitotoxin elicits a dose-dependent stimulation of 45Ca2+ influx in glioma C6, pheochromocytoma PC12, insulinoma HIT and human blood cells, while having no effect in liposomes. In HIT cells maitotoxin also elicited influx of 86Rb+ greater than 22Na+ greater than 54Mn2+, but the stimulation was far less than for 45Ca2+.
M, Murata, F, Gusovsky, T, Yasumoto, J W, Daly   +3 more
openaire   +2 more sources

Modulation of a calcium-activated chloride current by Maitotoxin

Toxicon, 1999
The effect of Maitotoxin (MTX) on the calcium-activated chloride current (ICl-Ca) from Xenopus oocytes was studied, applying the two-electrode voltage clamp technique. MTX increased the current amplitude at all the voltages explored and reduced the time to reach the maximum current level (time to peak). At low toxin concentrations (15 pM), both effects
M, Martínez, C, Salvador, J M, Farias, L, Vaca, L I, Escobar   +4 more
openaire   +2 more sources

ChemInform Abstract: Maitotoxin — An Inspiration for Synthesis

ChemInform, 2011
AbstractReview: 220 refs.
K. C. Nicolaou, Robert J. Aversa
openaire   +1 more source

Mechanisms underlying the hemolytic and ichthyotoxic activities of maitotoxin

Natural Toxins, 1999
Maitotoxin (MTX), a putative Ca(2+) channel activator produced by the dinoflagellate Gambierdiscus toxicus showed extremely potent hemolytic and ichthyotoxic activities. Hemolysis of 1% mouse blood cell suspension in saline occurred at 15 nM of MTX.
T, Igarashi, S, Aritake, T, Yasumoto
openaire   +2 more sources

ChemInform Abstract: Complete Structure of Maitotoxin

ChemInform, 1998
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
openaire   +1 more source

Maitotoxin, a cationic channel activator.

Neurobiology (Budapest, Hungary), 1998
Maitotoxin (MTX), a water soluble polyether obtained from the marine dinoflagellate Gambierdiscus toxicus is one of the entities responsible for Ciguatera, a form of seafood poisoning. This toxin is a potent activator of changes in the intracellular Ca2+ concentrations of cells from a wide variety of organisms.
L I, Escobar, C, Salvador, M, Martínez, L, Vaca   +3 more
openaire   +1 more source

Maitotoxin-induced Free Ca Changes in Single Rat Hepatocytes

Cellular Signalling, 1999
We report the results using bioluminescent and fluorescent indicators to investigate maitotoxin-induced free Ca changes in single rat hepatocytes. Maitotoxin generated a steadily rising free Ca increase after a long lag period. The free Ca increase was dependent on extracellular calcium and could be antagonised by chelation of extracellular calcium or ...
N M, Woods, C J, Dixon, T, Yasumoto, K S, Cuthbertson, P H, Cobbold   +4 more
openaire   +2 more sources

Chemical Synthesis of the GHIJKLMNO Ring System of Maitotoxin

Journal of the American Chemical Society, 2008
As the largest secondary metabolite to be discovered as of yet, the polyether marine neurotoxin maitotoxin constitutes a major structural and synthetic challenge. After its originally proposed structure ( 1) had been questioned on the basis of biosynthetic considerations, we provided computational and experimental support for structure 1.
K C, Nicolaou, Michael O, Frederick, Antonio C B, Burtoloso, Ross M, Denton, Fatima, Rivas, Kevin P, Cole, Robert J, Aversa, Romelo, Gibe, Taiki, Umezawa, Takahiro, Suzuki   +9 more
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Dopamine inhibits maitotoxin-stimulated pituitary 45Ca2+ efflux and prolactin release

American Journal of Physiology-Endocrinology and Metabolism, 1986
We examined the hypothesis that dopaminergic inhibition of prolactin release is coupled to modulation of cellular calcium flux. Dispersed female rat pituitary cells were prelabeled in 45Ca2+ and perifused to determine simultaneously fractional calcium efflux and prolactin release, as stimulated by maitotoxin, a calcium channel activator. The integrated
I S, Login, A M, Judd, R M, MacLeod
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Ca2+ channel activating action of maitotoxin in cultured brainstem neurons

European Journal of Pharmacology, 2006
The actions of maitotoxin were studied using cultured brainstem cells and adrenal chromaffin cells. Maitotoxin induced a profound increase in the Ca2+ influx into cultured brainstem cells after a brief lag period. The maitotoxin-induced Ca2+ influx was suppressed by various voltage-dependent Ca2+ channel blockers such as Co2+, Mn2+, verapamil and ...
Atsushi, Kakizaki, Masami, Takahashi, Hiroyuki, Akagi, Eiichi, Tachikawa, Toshifumi, Yamamoto, Eiichi, Taira, Tohru, Yamakuni, Yasushi, Ohizumi   +7 more
openaire   +2 more sources