Results 181 to 190 of about 1,190 (207)

Modulation of the maitotoxin response by intracellular and extracellular cations

Toxicon, 2002
The aim of the present study was to characterize the role played by intracellular and extracellular calcium and sodium on the maitotoxin (MTX) response in Chinese hamster ovary (CHO) cells. The results presented here indicated that: (1) MTX activates calcium and sodium influx in a concentration-dependent manner; (2) extracellular calcium is required ...
V, Morales-Tlalpan, L, Vaca
openaire   +2 more sources

Modulation of a calcium-activated chloride current by Maitotoxin

Toxicon, 1999
The effect of Maitotoxin (MTX) on the calcium-activated chloride current (ICl-Ca) from Xenopus oocytes was studied, applying the two-electrode voltage clamp technique. MTX increased the current amplitude at all the voltages explored and reduced the time to reach the maximum current level (time to peak). At low toxin concentrations (15 pM), both effects
M, Martínez, C, Salvador, J M, Farias, L, Vaca, L I, Escobar   +4 more
openaire   +2 more sources

Maitotoxin

2000
Abstract Ciguatoxin, scaritoxin, and maitotoxin (MTX) are the marine compounds held responsible for ciguatera poisoning, although the role of MTX is disputed (8). Like ciguatoxin, MTX is produced by the marine dinoflagellate Gambier discus toxicus, and accumulates in the marine food chain in fish in tropical coral reefs.
openaire   +1 more source

Maitotoxin-induced membrane current in neuroblastoma cells

Brain Research, 1987
Maitotoxin (MTX) is a potent marine toxin isolated from the toxic dinoflagellate, Gambierdiscus toxicus. We have examined the possibility of MTX activating calcium channels using cultured neuroblastoma cells (N1E-115). MTX (10 ng/ml) produced a depolarization of the membrane, which was prevented by the removal of Ca2+ from the external medium.
M, Yoshii, A, Tsunoo, Y, Kuroda, C H, Wu, T, Narahashi   +4 more
openaire   +2 more sources

Chemical Synthesis of the GHIJKLMNO Ring System of Maitotoxin

Journal of the American Chemical Society, 2008
As the largest secondary metabolite to be discovered as of yet, the polyether marine neurotoxin maitotoxin constitutes a major structural and synthetic challenge. After its originally proposed structure ( 1) had been questioned on the basis of biosynthetic considerations, we provided computational and experimental support for structure 1.
K C, Nicolaou, Michael O, Frederick, Antonio C B, Burtoloso, Ross M, Denton, Fatima, Rivas, Kevin P, Cole, Robert J, Aversa, Romelo, Gibe, Taiki, Umezawa, Takahiro, Suzuki   +9 more
openaire   +2 more sources

Convergent Synthesis of the WXYZA′B′C′D′E′F′ Ring Segment of Maitotoxin

Bulletin of the Chemical Society of Japan, 2022
Keiichi Konoki, Yoko Yasuno, Masayuki Satake   +2 more
exaly  

Toxicity Screening of a Gambierdiscus australes Strain from the Western Mediterranean Sea and Identification of a Novel Maitotoxin Analogue

Marine Drugs, 2021
Manoella Sibat-Dubois, Ana Gago Martinez, Angels Tudo Casanova   +2 more
exaly  

Zur Struktur des Maitotoxins

Angewandte Chemie, 2007
K. C. Nicolaou, Michael O. Frederick
openaire   +1 more source

Structure Elucidation and Biological Evaluation of Maitotoxin-3, a Homologue of Gambierone, from Gambierdiscus belizeanus

Toxins, 2019
Kevin Calabro, I Rodríguez, Olivier P Thomas   +2 more
exaly  

The Complete Structure of Maitotoxin, Part I: Configuration of the C1C14 Side Chain

Angewandte Chemie International Edition in English, 1996
Michio Murata, Nobuaki Matsumori, Makoto Sasaki   +2 more
exaly