Results 81 to 90 of about 811 (177)

Marine Heterocyclic Compounds That Modulate Intracellular Calcium Signals: Chemistry and Synthesis Approaches. [PDF]

Mar Drugs, 2021
González-Andrés P, Fernández-Peña L, Díez-Poza C, Villalobos C, Nuñez L, Barbero A.   +5 more
europepmc   +1 more source

Transient Ca2+-dependent activation of ERK1 and ERK2 in cytotoxic responses induced by maitotoxin in breast cancer cells

, 1999
Treatment of MCF-7 breast cancer cells with the marine toxin maitotoxin (MTX) induces cell death. The cytotoxic effects are clearly detectable within 2-4 h after cell treatment with 10(-10)-10(-9) M concentrations of MTX, The response was found to depend
Takeshi Yasumoto, Gian Paolo Rossini, C. Malaguti, Yasumoto, Takeshi, Claudia Malaguti, T. Yasumoto, Malaguti, Claudia, Paolo Rossini, Gian, ROSSINI, Gian Paolo   +8 more
core   +1 more source

Calcium, cAMP, and dopamine affect single mammotrophs assayed by hemolytic plaques

, 1985
We investigated the effects of dopamine, forskolin, and maitotoxin on prolactin release from individual rat and monkey mammotrophs. Forskolin increases cAMP levels, whereas maitotoxin amplifies the influx of extracellular calcium.
J. M. Anderson, M. J. Cronin, D. A. Keefer, D. D. Koritnik, T. Yasumoto   +4 more
core   +1 more source

NLRP3 Inflammasome as Therapeutic Targets in Inflammatory Diseases. [PDF]

Biomol Ther (Seoul), 2023
Prakash AV, Park IH, Park JW, Bae JP, Lee GS, Kang TJ.   +5 more
europepmc   +1 more source

Maitotoxin activates a nonselective cation channel and a P2Z/P2X₇-like cytolytic pore in human skin fibroblasts

, 1999
Maitotoxin (MTX), a potent cytolytic agent, activates Ca2+entry via nonselective cation channels in virtually all types of cells. The identity of the channels involved and the biochemical events leading to cell lysis remain unknown. In the present study,
Mark Estacion, William P. Schilling, William G. Sinkins   +2 more
core   +1 more source

Phytoplankton Toxins and Their Potential Therapeutic Applications: A Journey toward the Quest for Potent Pharmaceuticals. [PDF]

Mar Drugs, 2022
Pradhan B, Ki JS.
europepmc   +1 more source

Discovery of benthol A and its challenging stereochemical assignment: opening up a new window for skeletal diversity of super-carbon-chain compounds. [PDF]

Chem Sci, 2021
Jiang ZP, Sun SH, Yu Y, Mándi A, Luo JY, Yang MH, Kurtán T, Chen WH, Shen L, Wu J.   +9 more
europepmc   +1 more source

Membrane depolarization in LA-N-1 cells: the effect of maitotoxin is Ca2+ and Na+ dependent

, 1997
We investigated the influence of ion compositions on the membrane potential in LA-N-1 human neuroblastoma cells using bisoxonol as a potential-sensitive fluorescent dye.
SINGH I. N. AND KANFER J. N., MONSURRO' M. R., SORRENTINO, Giuseppe   +2 more
core  

Sulfo-Gambierones, Two New Analogs of Gambierone Produced by Gambierdiscus excentricus. [PDF]

Mar Drugs, 2021
Yon T, Sibat M, Robert E, Lhaute K, Holland WC, Litaker RW, Bertrand S, Hess P, Réveillon D.   +8 more
europepmc   +1 more source

Perspectives from nearly five decades of total synthesis of natural products and their analogues for biology and medicine. [PDF]

Nat Prod Rep, 2020
Nicolaou KC, Rigol S.
europepmc   +1 more source