Results 71 to 80 of about 1,190 (207)
Convergent Synthesis and Biological Activity of the WXYZA′B′C′ Ring System of Maitotoxin
, 2016 The WXYZA′B′C′ ring system (1) of maitotoxin (MTX) was synthesized in a convergent manner via successive coupling of the W, Z, and C′ ring fragments through construction of the XY and A′B′ ring systems.
Futoshi Hasegawa (2112709) +5 more
core +2 more sources
Maitotoxin, a Ca2+ channel activator candidate.
Journal of Biological Chemistry, 1982 Effects of maitotoxin, the most potent marine toxin, were studied using a rat pheochromocytoma cell line, PC12h. A low concentration (10(-8) g/ml) of maitotoxin induced a profound increase in CA2+ influx into PC12h cells and the Ca2+-dependent release of [3H]norepinephrine from them.
M, Takahashi, Y, Ohizumi, T, Yasumoto
openaire +2 more sources
Synthetic Studies on Maitotoxin. 3. Stereoselective Synthesis of the BCDE-Ring System
, 2016 The stereoselective synthesis of the BCDE-ring system of maitotoxin has been accomplished through a two-directional strategy for the construction of polycyclic ether.
Tadashi Nakata (2103187) +2 more
core +2 more sources
Synthesis of the QRSTU Domain of Maitotoxin and Its 85-epi- and 86-epi-Diastereoisomers
, 2016 A devised synthetic strategy toward the QRSTU ring system 4 of the marine-derived biotoxin maitotoxin (1) delivered, in addition to 4, its diastereoisomers 85-epi-QRSTU and 86-epi-QRSTU ring systems 5 and 6.
Taiki Umezawa (2008570) +4 more
core +1 more source
Synthesis and Biological Activity of the C′D′E′F′ Ring System of Maitotoxin
, 2016 Stereoselective synthesis of the C′D′E′F′ ring system of maitotoxin was achieved starting from the E′ ring through successive formation of the D′ and C′ rings based on SmI2-mediated reductive cyclization.
Takahiro Oshima (81705) +6 more
core +1 more source
, 1990 Gambierdiscus toxicus strains isolated from Australia and French Polynesia were grown in modified f2 and f10 nutrient media and the cells extracted for ciguatoxin and maitotoxin.
Lewis, Richard J. +5 more
core +1 more source
Calcium is permeable through a maitotoxin-activated nonselective cation channel in mouse L cells
, 1996 The shellfish poison maitotoxin causes the irreversible opening of nonselective cation channels in mouse L cell fibroblasts, consistent with the action of this toxin in other cell types and the previously demonstrated existence of 28-pS voltage ...
M. Estacion, J. J. Gargus, H. B. Nguyen
core +1 more source
, 2016 The stereoselective synthesis of the maitotoxin C′D′E′F′-ring system having a side chain has been accomplished through a convergent strategy. The key reactions include Horner-Wadsworth-Emmons coupling of the C′D′E′-ring and the side chain and subsequent ...
Tadashi Nakata (2103187) +3 more
core +2 more sources
Synthetic Studies on Maitotoxin. 2. Stereoselective Synthesis of the WXYZA′-Ring System
, 2016 The stereoselective synthesis of the WXYZA′-ring system of maitotoxin has been accomplished via a linear synthetic approach, in which key reactions were SmI2-induced cyclization of β-alkoxyacrylate for the construction of the A′-, Y-, and X-rings and 6 ...
Tadashi Nakata (2103187) +3 more
core +1 more source
Neurotoxic Syndromes in Marine Poisonings a Review
Iranian South Medical Journal, 2014 Background: Marine neurotoxins as of Marine biotoxins are natural toxins that produced mainly by dinoflagellates, diatoms and several species of invertebrates and fish.
Gholam Hossein Mohebbi +2 more
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