Synthesis of the WXYZA′ Domain of Maitotoxin
, 2016 A synthesis of the WXYZA′ domain (7) of the marine neurotoxin maitotoxin (1) is reported. The convergent synthetic strategy involves construction of key building blocks 11 and 12, their coupling, and the elaboration of the resulting ester (10) to the ...
Tsuyoshi Nakamura (1343718) +2 more
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Pannexin-1 couples to maitotoxin and nigericin- induced il-1β release through a dye-uptake independent pathway [PDF]
, 2007 ©2007. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Accepte version of a Published Work that appeared in final form in Journal of Biological Chemistry.
Pelegrin, Pablo, Surprenant, Annmarie
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The isolation and purification of a caribbean maitotoxin
, 1994 The phenomenon known as red tide has been a topic of great interest in that there is concern that the scale and complexity of this natural phenomenon are expanding. It is known that the benthic dinoflagellate, Gambierdiscus toxicus, produces a variety of polyether toxins that contaminate seafood and result in human illness.
S E Davis, S M Knoepp, B A Lanoue
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Inhibition of Maitotoxin‐Induced Ca2+ Influx in Rat Glioma C6 Cells by Brevetoxins and Synthetic Fragments of Maitotoxin [PDF]
Journal of Neurochemistry, 1998 Abstract: 45Ca2+ influx in rat glioma C6 cells induced by 0.3 nM maitotoxin (MTX) was markedly inhibited by brevetoxin A (PbTx1) and brevetoxin B (PbTx2), with EC50 values of 16 and 13 µM, respectively. This inhibition was observed immediately after addition of MTX when monitored with fura‐2, which suggests that PbTx2 directly blocks the action of MTX.
K, Konoki +5 more
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Maitotoxin stimulates steroid and peptide hormone secretion by swine luteal tissue
, 1987 The impact of calcium influx on the secretion of steroidal and nonsteroidal ovarian products was tested using a novel marine toxin, maitotoxin, a putative activator of endogenous calcium channels.
K. Yoshida +3 more
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Convergent Synthesis and Biological Activity of the WXYZA′B′C′ Ring System of Maitotoxin
, 2016 The WXYZA′B′C′ ring system (1) of maitotoxin (MTX) was synthesized in a convergent manner via successive coupling of the W, Z, and C′ ring fragments through construction of the XY and A′B′ ring systems.
Futoshi Hasegawa (2112709) +5 more
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Synthetic Studies on Maitotoxin. 3. Stereoselective Synthesis of the BCDE-Ring System
, 2016 The stereoselective synthesis of the BCDE-ring system of maitotoxin has been accomplished through a two-directional strategy for the construction of polycyclic ether.
Tadashi Nakata (2103187) +2 more
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Synthesis of the QRSTU Domain of Maitotoxin and Its 85-epi- and 86-epi-Diastereoisomers
, 2016 A devised synthetic strategy toward the QRSTU ring system 4 of the marine-derived biotoxin maitotoxin (1) delivered, in addition to 4, its diastereoisomers 85-epi-QRSTU and 86-epi-QRSTU ring systems 5 and 6.
Taiki Umezawa (2008570) +4 more
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Maitotoxin, a Ca2+ channel activator candidate.
Journal of Biological Chemistry, 1982 Effects of maitotoxin, the most potent marine toxin, were studied using a rat pheochromocytoma cell line, PC12h. A low concentration (10(-8) g/ml) of maitotoxin induced a profound increase in CA2+ influx into PC12h cells and the Ca2+-dependent release of [3H]norepinephrine from them.
M, Takahashi, Y, Ohizumi, T, Yasumoto
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Synthesis and Biological Activity of the C′D′E′F′ Ring System of Maitotoxin
, 2016 Stereoselective synthesis of the C′D′E′F′ ring system of maitotoxin was achieved starting from the E′ ring through successive formation of the D′ and C′ rings based on SmI2-mediated reductive cyclization.
Takahiro Oshima (81705) +6 more
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