Results 51 to 60 of about 1,584 (185)

[Retracted] Genetic and Functional Profiling of Crohn′s Disease: Autophagy Mechanism and Susceptibility to Infectious Diseases

BioMed Research International, Volume 2013, Issue 1, 2013., 2013
Crohn′s disease is a complex disease in which genome, microbiome, and environment interact to produce the immunological background of the disease. Disease in childhood is more extensive and characterized by a rapid progression, leading to severe repercussions in the course of the disorder.
Annalisa Marcuzzi, Anna Monica Bianco, Martina Girardelli, Alberto Tommasini, Stefano Martelossi, Lorenzo Monasta, Sergio Crovella, Enrique Medina-Acosta   +7 more
wiley   +1 more source

A common response to common danger? Comparison of animal and plant signaling pathways involved in cadmium sensing

Journal of Cell Communication and Signaling, Volume 6, Issue 4, Page 191-204, December 2012., 2012
Abstract Exposure to cadmium results in disturbances in cell homeostasis in all living organisms. The first response to stress factors, including cadmium, is activation of signal transduction pathways that mobilize cell defense mechanisms. The aim of this review is a comparison between the signaling network triggered by Cd in plants and animals ...
Jagna Chmielowska‐Bąk, Joanna Deckert
wiley   +1 more source

Inflammasomes: Molecular Regulation and Implications for Metabolic and Cognitive Diseases [PDF]

, 2014
Inflammasomes are specialized signaling platforms critical for the regulation of innate immune and inflammatory responses. Various NLR family members (i.e., NLRP1, NLRP3, and IPAF) as well as the PYHIN family member AIM2 can form inflammasome complexes ...
Choi, Alexander J.S., Ryter, Stefan W.
core   +1 more source

Nanocarrier‐Based Targeting of Pattern Recognition Receptors as an Innovative Strategy for Enhancing Sepsis Therapy

Advanced Healthcare Materials, Volume 14, Issue 23, September 8, 2025.
This review highlights recent progress in nanocarriers targeting pattern recognition receptors (PRRs), including Toll‐like and NOD‐like receptors, for enhancing the treatment of bacterial sepsis and related complications. These nanomedicines deliver antibiotics and anti‐inflammatory agents while modulating immune responses.
Eman A. Ismail, Vincent O. Nyandoro, Calvin A. Omolo, Thirumala Govender   +3 more
wiley   +1 more source

Modulating P2X7 Receptor Signaling during Rheumatoid Arthritis: New Therapeutic Approaches for Bisphosphonates

Journal of Osteoporosis, Volume 2012, Issue 1, 2012., 2012
P2X7 receptor‐mediated purinergic signaling is a well‐known mechanism involved in bone remodeling. The P2X7 receptor has been implicated in the pathophysiology of various bone and cartilage diseases, including rheumatoid arthritis (RA), a widespread and complex chronic inflammatory disorder. The P2X7 receptor induces the release into the synovial fluid
Alberto Baroja-Mazo, Pablo Pelegrín, Niklas Rye Jørgensen   +2 more
wiley   +1 more source

Identification of calcium-binding proteins associated with the human sperm plasma membrane [PDF]

, 2010
Background The precise composition of the human sperm plasma membrane, the molecular interactions that define domain specific functions, and the regulation of membrane associated proteins during the capacitation process, still remain to be fully ...
Soren Naaby-Hansen, Alan Diekman, Jagathpala Shetty, Charles J Flickinger, Anne Westbrook, John C Herr, L Jovine, HM Florman, A Darszon, A Darszon, C Arnoult, R Felix, CM O'Toole, G De Blas, S Naaby-Hansen, MK Jungnickel, J Malm, RA Bronson, S Naaby-Hansen, S Naaby-Hansen, WJ Henzel, P Matsudaira, K Maruyama, AB Diekman, J Shetty, P Primakoff, BK Shin, ME Calvert, C Bohring, C Hastie, A Mandal, GA Tennent, UA Kiernan, M Sriram, L Serrano, KC Fong, Y Kitao, D Miller, B Danielsen, NH Heegaard, PS Hicks, RC Riley-Vargas, A Familian, CLF Ciurana, M Bijl, AP van Rossum, D Bharadwaj, C Mold, SJ Kim, V Pittoni, A Roos, H Gewurz, MR Brown, MB Pepys, MCM Bickerstaff, IJ Pandya, DM Phillips, JM Bedford, K Venkatachalam, CL Treviño, CL Treviño, X Zhu, B Vannier, B Nilius, L Stowers, BG Leypold, SL Zhang, S Stamboulian, BC Suh, KA Sutton, D Gkika, M Hirai, KC Goh, M Kanai, YM Li, S Brûlé, NP Smithers, K Kawaai, JP Schoeber, Q Chang, DM Cohen, ES Trombetta, CW Arendt, H Breitbart, CM O'Toole, M Sousa, DY Liu, H Breitbart, H Breitbart, S Naaby-Hansen   +89 more
core   +1 more source

Opinion of the French Agency for Food, Environmental and Occupational Health & Safety (ANSES) on the risks to human health associated with the proliferation of Ostreopsis spp. on the Basque coast

Food Risk Assess Europe, Volume 3, Issue 2, April 2025.
Abstract In France, the presence of marine microalgae of the genus Ostreopsis has been identified repeatedly on the Mediterranean coast for several years, whereas on the French Basque coasts its presence is much more recent. In the summers of 2021 and 2022, major Ostreopsis flowering episodes were reported on the Basque coast, resulting in several ...
Rodolphe Lemée, Jean‐François Humbert, Eric Abadie, Zouher Amzil, Elisa Berdalet, Ronel Biré, Marie‐Yasmine Dechraoui Bottein, Luc de Haro, Nicolas Delcourt, Valérie Fessard, Jean‐Philippe Jaeg, César Mattei, Anne Oppliger, Anne‐Sophie Pavaux, Eva Ternon, Gilles Bornert, Anne Togola, Jean Baron, Jean‐Luc Boudenne, Nicolas Cimetiere, Bruno Coulomb, Christophe Dagot, Sabine Denooz, Isabelle Dublineau, Frédéric Feder, Matthieu Fournier, Stéphane Garnaud‐Corbel, Nathalie Garrec, Johnny Gasperi, Julio Gonçalvès, Jean‐Louis Gonzalez, Olivier Horner, Michel Joyeux, Jérôme Labanowski, Sophie Lardy‐Fontan, Françoise Lucas, Christophe Mechouk, Laurent Moulin, Damien Mouly, Fabienne Petit, Catherine Quiblier, Pauline Rousseau‐Gueutin, Marie‐Pierre Sauvant‐Rochat, Michèle Tremblay, Bruno Le Bizec, Marie‐Louise Scippo, Pierre‐Marie Badot, Marie‐Yasmine Bottein, Rachida Chekri, Christine Demeilliers, Virginie Desvignes, Erwan Engel, Gautier Eppe, Anne‐Sophie Ficheux, Eric Houdeau, Emilie Lance, Olivier Laprevote, Michel Laurentie, Ludovic Le Hegarat, Jean‐Charles Leblanc, Nicolas Loiseau, David Makowski, Francesca Mancini, Eric Marchioni, Jean‐François Masfaraud, Mathilde Munier, Isabelle Oswald, Anne Platel, Yann Sivry, Paule Vasseur, Estelle Checlair‐Westerberg, Eléonore Ney, Nathalie Arnich, Carole Catastini   +73 more
wiley   +1 more source

Role of the Inflammasome, IL‐1β, and IL‐18 in Bacterial Infections

The Scientific World Journal, Volume 11, Issue 1, Page 2037-2050, 2011., 2011
The inflammasome is an important innate immune pathway that regulates at least two host responses protective against infections: (1) secretion of the proinflammatory cytokines IL‐1β and IL‐18 and (2) induction of pyroptosis, a form of cell death. Inflammasomes, of which different types have been identified, are multiprotein complexes containing pattern
Manoranjan Sahoo, Ivonne Ceballos-Olvera, Laura del Barrio, Fabio Re, Giamila Fantuzzi   +4 more
wiley   +1 more source

Inhibition of Maitotoxin‐Induced Ca²⁺ Influx in Rat Glioma C6 Cells by Brevetoxins and Synthetic Fragments of Maitotoxin [PDF]

Journal of Neurochemistry, 1998
Abstract: 45Ca2+ influx in rat glioma C6 cells induced by 0.3 nM maitotoxin (MTX) was markedly inhibited by brevetoxin A (PbTx1) and brevetoxin B (PbTx2), with EC50 values of 16 and 13 µM, respectively. This inhibition was observed immediately after addition of MTX when monitored with fura‐2, which suggests that PbTx2 directly blocks the action of MTX.
K, Konoki, M, Hashimoto, T, Nonomura, M, Sasaki, M, Murata, K, Tachibana   +5 more
openaire   +2 more sources

Differential IL-1β secretion by monocyte subsets is regulated by Hsp27 through modulating mRNA stability. [PDF]

, 2016
Monocytes play a central role in regulating inflammation in response to infection or injury, and during auto-inflammatory diseases. Human blood contains classical, intermediate and non-classical monocyte subsets that each express characteristic patterns ...
A MacKenzie, A Piccini, AA Sharma, AM Knapinska, AM Zawada, B Passlick, C Antonopoulos, CA Dinarello, D Kontoyiannis, D Perregaux, DJ Stumpo, E Carballo, E Shantsila, E Vigano, E Wang, F Martinon, G Buell, G Laroia, G Shaw, GM Wilson, IA Vlasova, J Cros, J Maelfait, JA Hagar, JH Edwan, JR Ward, JY Lu, JY Lu, KL Wong, KL Wong, KS Sinsimer, L Ziegler-Heitbrock, M Alfaidi, ME Edye, MG Netea, N Kayagaki, N Marina-Garcia, N Sadri, P Ancuta, P Ivanov, P Pelegrin, P Pelegrin, P Pelegrin, RA Black, RG Snodgrass, SD Wright, T Kastelic, T Takenouchi, T Takenouchi, VA Rathinam, WP Arend, Y Qu, YL Chen, ZJ Shen   +53 more
core   +1 more source