Results 41 to 50 of about 1,190 (207)
High Value Phycotoxins From the Dinoflagellate Prorocentrum
Frontiers in Marine Science, 2021 Marine dinoflagellates produce chemically diverse compounds, with a wide range of biological activity (antimicrobial, anticancer, treatment of neurodegenerative disease along with use as biomedical research tools).
Dolores Camacho-Muñoz +3 more
doaj +1 more source
Complete Structure of Maitotoxin.
Journal of Synthetic Organic Chemistry, Japan, 1997 Maitotoxin (MTX, 1) is the most toxic and largest non-biopolymer known to date. The complete structural determination of MTX including the absolute configuration has been achieved recently. The relative configurations of the four acyclic portions (C1-C15, C35-C39, C63-C68, and C134-C142) were elucidated by (1) the extensive configurational analysis ...
SASAKI, Makoto, MURATA, Michio
openaire +3 more sources
Chemical Synthesis of the GHIJKLMNO Ring System of Maitotoxin
, 2016 As the largest secondary metabolite to be discovered as of yet, the polyether marine neurotoxin maitotoxin constitutes a major structural and synthetic challenge.
Taiki Umezawa (2008570) +9 more
core +2 more sources
Alternative method to detect compounds produced by Gambierdiscus spp.
Frontiers in Marine Science, 2014 Ciguatoxins (CTXs) and CTX precursors are produced by several Gambierdiscus spp. These polyether toxins are associated to ciguatera fish poisoning (CFP). In addition to CTX, maitotoxins (MTX) and gambierol are also produced by these dinoflagellates.
Jon Andoni Sánchez
doaj +1 more source
Ladder-Shaped Ion Channel Ligands: Current State of Knowledge
Marine Drugs, 2017 Ciguatoxins (CTX) and brevetoxins (BTX) are polycyclic ethereal compounds biosynthesized by the worldwide distributed planktonic and epibenthic dinoflagellates of Gambierdiscus and Karenia genera, correspondingly.
Yuri B. Shmukler, Denis A. Nikishin
doaj +1 more source
Synthesis of the ABCDEFG Ring System of Maitotoxin
, 2016 Maitotoxin (1) continues to fascinate scientists not only because of its size and potent neurotoxicity but also due to its molecular architecture. To provide further support for its structure and facilitate fragment-based biological studies, we developed
Fatima Rivas (1883584) +3 more
core +2 more sources
Release of full-length PrPC from cultured neurons following neurotoxic challenges
Frontiers in Neurology, 2012 The susceptibility of the normal cellular prion protein isoform, PrPC, to proteolytic digestion has been well documented. In addition, a link between PrPC and the cytosolic protease, calpain, has been reported although the specifics of the interaction ...
Kevin K W Wang +6 more
doaj +1 more source
Marine Drugs, 2017 Species in the genus Gambierdiscus produce ciguatoxins (CTXs) and/or maitotoxins (MTXs), which may cause ciguatera fish poisoning (CFP) in humans if contaminated fish are consumed. Species of Gambierdiscus have previously been isolated from macroalgae at
Lesley L. Rhodes +5 more
doaj +1 more source
Toxicity Characterisation of Gambierdiscus Species from the Canary Islands
Toxins, 2020 In the last decade, several outbreaks of ciguatera fish poisoning (CFP) have been reported in the Canary Islands (central northeast Atlantic Ocean), confirming ciguatera as an emerging alimentary risk in this region.
Araceli E. Rossignoli +5 more
doaj +1 more source
Synthesis of the C′D′E′F′ Domain of Maitotoxin
, 2016 A devised biomimetic strategy toward the C′D′E′F′ domain (6) of maitotoxin (1) led to hydroxy triepoxide 8 as a postulated polyepoxide precursor. However, all attempts to induce the desired cascade to form the targeted compound through a zip-type ...
Tsuyoshi Nakamura (1343718) +3 more
core +2 more sources