Effects of Four Marine Toxins on Murine Hepatic Biotransformation Enzymes [PDF]
ToxinsThis study assesses the impact of sublethal levels of four marine toxins ciguatoxin (CTX-1), maitotoxin-2 (MTX-2), saxitoxin (STX) and brevetoxin-2 (BTX-2) on murine hepatic detoxification enzymes expressed in mouse liver.
Joanna Soto de Jesus +5 more
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Targeted Metabolite Fingerprints of Thirteen Gambierdiscus, Five Coolia and Two Fukuyoa Species [PDF]
Marine DrugsThe genus Gambierdiscus produces an array of bioactive hydrophilic and lipophilic secondary metabolites that range in mode of action and toxicity. In this study, the metabolite fingerprint was mapped for thirteen Gambierdiscus, five Coolia and two ...
J. Sam Murray +12 more
doaj +2 more sources
Synthesis of the WXYZA′ Domain of Maitotoxin [PDF]
Journal of the American Chemical Society, 2010 A synthesis of the WXYZA' domain (7) of the marine neurotoxin maitotoxin (1) is reported. The convergent synthetic strategy involves construction of key building blocks 11 and 12, their coupling, and the elaboration of the resulting ester (10) to the target molecule through a ring-closing metathesis and a hydroxy dithioketal cyclization as the key ...
K C, Nicolaou +2 more
openaire +4 more sources
PLoS ONE, 2016 BackgroundCiguatera is a circumtropical disease produced by polyether sodium channel toxins (ciguatoxins) that enter the marine food chain and accumulate in otherwise edible fish.
Richard J Lewis +6 more
doaj +2 more sources
Synthesis of the C′D′E′F′ Domain of Maitotoxin [PDF]
Journal of the American Chemical Society, 2010 A devised biomimetic strategy toward the C'D'E'F' domain (6) of maitotoxin (1) led to hydroxy triepoxide 8 as a postulated polyepoxide precursor. However, all attempts to induce the desired cascade to form the targeted compound through a zip-type reaction under neutral or acidic conditions failed, prompting adoption of a linear stepwise approach to 6 ...
K C, Nicolaou +3 more
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Synthesis of the ABCDEFG Ring System of Maitotoxin [PDF]
Journal of the American Chemical Society, 2010 Maitotoxin (1) continues to fascinate scientists not only because of its size and potent neurotoxicity but also due to its molecular architecture. To provide further support for its structure and facilitate fragment-based biological studies, we developed an efficient chemical synthesis of the ABCDEFG segment 3 of maitotoxin.
K C, Nicolaou +3 more
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Pannexin-1 Couples to Maitotoxin- and Nigericin-induced Interleukin-1β Release through a Dye Uptake-independent Pathway [PDF]
, 2006 ©2007. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Accepte version of a Published Work that appeared in final form in Journal of Biological Chemistry.
Pablo Pelegrı́n, Annmarie Surprenant
core +4 more sources
Maitotoxin activates an endogenous non-selective cation channel and is an effective initiator of the activation of the heterologously expressed hTRPC-1 (transient receptor potential) non-selective cation channel in H4-IIE liver cells [PDF]
, 2001 Copyright © 2001 Elsevier Science B.V. All rights reserved.The structures and mechanisms of activation of non-selective cation channels (NSCCs) are not well understood although NSCCs play important roles in the regulation of metabolism, ion transport ...
Helen Mary Brereton +4 more
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Differential Effects of Ciguatoxin and Maitotoxin in Primary Cultures of Cortical Neurons
Chemical Research in Toxicology, 2014 Ciguatoxins (CTXs) and maitotoxins (MTXs) are polyether ladder shaped toxins derived from the dinoflagellate Gambierdiscus toxicus. Despite the fact that MTXs are 3 times larger than CTXs, part of the structure of MTXs resembles that of CTXs. To date, the synthetic ciguatoxin, CTX 3C has been reported to activate voltage-gated sodium channels, whereas ...
Victor Martin +6 more
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Transient Ca2+‐dependent activation of ERK1 and ERK2 in cytotoxic responses induced by maitotoxin in breast cancer cells [PDF]
, 1999 Treatment of MCF-7 breast cancer cells with the marine toxin maitotoxin (MTX) induces cell death. The cytotoxic effects are clearly detectable within 2-4 h after cell treatment with 10(-10)-10(-9) M concentrations of MTX, The response was found to depend
Claudia Malaguti +2 more
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