Results 31 to 40 of about 811 (177)
Release of full-length PrPC from cultured neurons following neurotoxic challenges
Frontiers in Neurology, 2012 The susceptibility of the normal cellular prion protein isoform, PrPC, to proteolytic digestion has been well documented. In addition, a link between PrPC and the cytosolic protease, calpain, has been reported although the specifics of the interaction ...
Kevin K W Wang +6 more
doaj +1 more source
Toxicity Characterisation of Gambierdiscus Species from the Canary Islands
Toxins, 2020 In the last decade, several outbreaks of ciguatera fish poisoning (CFP) have been reported in the Canary Islands (central northeast Atlantic Ocean), confirming ciguatera as an emerging alimentary risk in this region.
Araceli E. Rossignoli +5 more
doaj +1 more source
Marine Drugs, 2017 Species in the genus Gambierdiscus produce ciguatoxins (CTXs) and/or maitotoxins (MTXs), which may cause ciguatera fish poisoning (CFP) in humans if contaminated fish are consumed. Species of Gambierdiscus have previously been isolated from macroalgae at
Lesley L. Rhodes +5 more
doaj +1 more source
Synthesis of the C′D′E′F′ Domain of Maitotoxin
, 2016 A devised biomimetic strategy toward the C′D′E′F′ domain (6) of maitotoxin (1) led to hydroxy triepoxide 8 as a postulated polyepoxide precursor. However, all attempts to induce the desired cascade to form the targeted compound through a zip-type ...
Tsuyoshi Nakamura (1343718) +3 more
core +2 more sources
Maitotoxin, a potent, general activator of phosphoinositide breakdown [PDF]
FEBS Letters, 1989 Maitotoxin (MTX), a potent marine toxin, elicits a calcium‐dependent activation of cells that can be inhibited by calcium channel blockers like nifedipine. MTX also stimulates phosphoinositide breakdown in smooth muscle cells, NCB‐20 cells and PC12 cells through a nifedipine‐insensitive mechanism.
Gusovsky, Fabian +2 more
openaire +2 more sources
Maitotoxin activates cation channels distinct from the receptor-activated non-selective cation channels of HL-60 cells [PDF]
, 1994 We investigated whether maitotoxin activates non-selective cation channels, as was recently proposed [Soergel, Yasumoto, Daly and Gusovsky (1992) Mol. Pharmacol. 41, 487-493].
Musgrave, I. F. +2 more
core +1 more source
Recent Trends in Marine Phycotoxins from Australian Coastal Waters
Marine Drugs, 2017 Phycotoxins, which are produced by harmful microalgae and bioaccumulate in the marine food web, are of growing concern for Australia. These harmful algae pose a threat to ecosystem and human health, as well as constraining the progress of aquaculture ...
Penelope Ajani +2 more
doaj +1 more source
NLRP3: A Novel Mediator in Cardiovascular Disease
Journal of Immunology Research, Volume 2018, Issue 1, 2018., 2018 Cardiovascular disease is a major cause of death worldwide. Inflammasome infiltration has been identified to play a central role in the pathological progression of certain cardiovascular diseases, such as vascular damage spanning atherosclerosis, aneurysm, or arteritis; ischemic heart disease; and other nonischemic heart diseases including diabetic ...
Wenyi Zhou +8 more
wiley +1 more source
Cell Death‐Associated Molecular‐Pattern Molecules: Inflammatory Signaling and Control
Mediators of Inflammation, Volume 2014, Issue 1, 2014., 2014 Apoptosis, necroptosis, and pyroptosis are different cellular death programs characterized in organs and tissues as consequence of microbes infection, cell stress, injury, and chemotherapeutics exposure. Dying and death cells release a variety of self‐proteins and bioactive chemicals originated from cytosol, nucleus, endoplasmic reticulum, and ...
Beatriz Sangiuliano +4 more
wiley +1 more source
BioMed Research International, Volume 2013, Issue 1, 2013., 2013 Crohn′s disease is a complex disease in which genome, microbiome, and environment interact to produce the immunological background of the disease. Disease in childhood is more extensive and characterized by a rapid progression, leading to severe repercussions in the course of the disorder.
Annalisa Marcuzzi +7 more
wiley +1 more source