Results 31 to 40 of about 1,584 (185)

Complete Structure of Maitotoxin.

Journal of Synthetic Organic Chemistry, Japan, 1997
Maitotoxin (MTX, 1) is the most toxic and largest non-biopolymer known to date. The complete structural determination of MTX including the absolute configuration has been achieved recently. The relative configurations of the four acyclic portions (C1-C15, C35-C39, C63-C68, and C134-C142) were elucidated by (1) the extensive configurational analysis ...
Makoto SASAKI, Michio MURATA
openaire   +3 more sources

Ladder-Shaped Ion Channel Ligands: Current State of Knowledge

Marine Drugs, 2017
Ciguatoxins (CTX) and brevetoxins (BTX) are polycyclic ethereal compounds biosynthesized by the worldwide distributed planktonic and epibenthic dinoflagellates of Gambierdiscus and Karenia genera, correspondingly.
Yuri B. Shmukler, Denis A. Nikishin
doaj   +1 more source

Traditional remedies used in the Western Pacific for the treatment of ciguatera poisoning [PDF]

, 1992
Ciguatera is a specific type of food poisoning associated with the ingestion of tropical fish, which, although normally safe for consumption, may at times contain high amounts of ciguatoxin, as well as other chemically related toxins.
Amade, Philippe, Bourdy, Geneviève, Cabalion, Pierre, Laurent, Dominique   +3 more
core   +1 more source

Rapid Extraction and Identification of Maitotoxin and Ciguatoxin-Like Toxins from Caribbean and Pacific Gambierdiscus Using a New Functional Bioassay.

PLoS ONE, 2016
BackgroundCiguatera is a circumtropical disease produced by polyether sodium channel toxins (ciguatoxins) that enter the marine food chain and accumulate in otherwise edible fish.
Richard J Lewis, Marco Inserra, Irina Vetter, William C Holland, D Ransom Hardison, Patricia A Tester, R Wayne Litaker   +6 more
doaj   +1 more source

Epoxide-Opening Cascades in the Synthesis of Polycyclic Polyether Natural Products [PDF]

, 2009
The structural features of polycyclic polyether natural products can, in some cases, be traced to their biosynthetic origin. However in case that are less well understood, only biosynthetic pathways that feature dramatic, yet speculative, epoxide-opening
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core   +1 more source

Release of full-length PrPC from cultured neurons following neurotoxic challenges

Frontiers in Neurology, 2012
The susceptibility of the normal cellular prion protein isoform, PrPC, to proteolytic digestion has been well documented. In addition, a link between PrPC and the cytosolic protease, calpain, has been reported although the specifics of the interaction ...
Kevin K W Wang, Kevin K W Wang, Susie eZoltewicz, Allen eChiu, Zhiqun eZhang, Zhiqun eZhang, Richard eRubenstein   +6 more
doaj   +1 more source

Toxicity Characterisation of Gambierdiscus Species from the Canary Islands

Toxins, 2020
In the last decade, several outbreaks of ciguatera fish poisoning (CFP) have been reported in the Canary Islands (central northeast Atlantic Ocean), confirming ciguatera as an emerging alimentary risk in this region.
Araceli E. Rossignoli, Angels Tudó, Isabel Bravo, Patricio A. Díaz, Jorge Diogène, Pilar Riobó   +5 more
doaj   +1 more source

Diversity-oriented synthesis of a library of substituted tetrahydropyrones using oxidative carbon-hydrogen bond activation and click chemistry [PDF]

, 2011
Eighteen (2RS,6RS)-2-(4-methoxyphenyl)-6-(substituted ethyl)dihydro- 2Hpyran-4(3H)ones were synthesized via a DDQ-mediated oxidative carbon-hydrogen bond activation reaction.
Farid, R, Floreancig, PE, LaPorte, MG, Liu, L, Wipf, P, Zaware, N   +5 more
core   +3 more sources

The Epiphytic Genus Gambierdiscus (Dinophyceae) in the Kermadec Islands and Zealandia Regions of the Southwestern Pacific and the Associated Risk of Ciguatera Fish Poisoning

Marine Drugs, 2017
Species in the genus Gambierdiscus produce ciguatoxins (CTXs) and/or maitotoxins (MTXs), which may cause ciguatera fish poisoning (CFP) in humans if contaminated fish are consumed. Species of Gambierdiscus have previously been isolated from macroalgae at
Lesley L. Rhodes, Kirsty F. Smith, Sam Murray, D. Tim Harwood, Tom Trnski, Rex Munday   +5 more
doaj   +1 more source

Contemporary views on inflammatory pain mechanisms: TRPing over innate and microglial pathways. [PDF]

, 2016
Tissue injury, whether by trauma, surgical intervention, metabolic dysfunction, ischemia, or infection, evokes a complex cellular response (inflammation) that is associated with painful hyperalgesic states.
Guan, Zhonghui, Hellman, Judith, Schumacher, Mark   +2 more
core   +2 more sources