Results 11 to 20 of about 811 (177)

Synthesis and Biological Evaluation of QRSTUVWXYZA′ Domains of Maitotoxin [PDF]

Journal of the American Chemical Society, 2014
The synthesis of QRSTUVWXYZA' domains 7, 8, and 9 of the highly potent marine neurotoxin maitotoxin (1), the largest secondary metabolite isolated to date, is described. The devised synthetic strategy entailed a cascade Takai-Utimoto ester olefination/ring closing metathesis to construct ring Y, a hydroxydithioketal cyclization/methylation sequence to ...
Nicolaou, K.C., Heretsch, Philipp, Nakamura, Tsuyoshi, Rudo, Anna, Murata, Michio, Konoki, Keiichi   +5 more
openaire   +4 more sources

Maitotoxin Is a Potential Selective Activator of the Endogenous Transient Receptor Potential Canonical Type 1 Channel in Xenopus laevis Oocytes [PDF]

Marine Drugs, 2017
Maitotoxin (MTX) is the most potent marine toxin known to date. It is responsible for a particular human intoxication syndrome called ciguatera fish poisoning (CFP). Several reports indicate that MTX is an activator of non-selective cation channels (NSCC)
Pedro L. Flores, Emma Rodríguez, Estrella Zapata, Roxana Carbó, José María Farías, Martín Martínez   +5 more
doaj   +2 more sources

The Formosalides: Structure Determination by Total Synthesis

Angewandte Chemie, Volume 133, Issue 1, Page 450-458, January 4, 2021., 2021
Total synthesis allowed the identification of the most likely stereostructure of the cytotoxic marine macrolides of the formosalide family (see structure) from eight possibilities. The successful route was based upon an inherently flexible blueprint that builds all stereogenic centers by strictly catalyst controlled transformations prior to formation ...
Saskia Schulthoff, James Y. Hamilton, Marc Heinrich, Yonghoon Kwon, Conny Wirtz, Alois Fürstner   +5 more
wiley   +2 more sources

Two‐pore channel 1 and Ca2+ release‐activated Ca2+ channels contribute to the acrosomal pH‐dependent intracellular Ca2+ increase in mouse sperm

The Journal of Physiology, Volume 601, Issue 14, Page 2935-2958, 15 July 2023., 2023
Abstract figure legend Amphipathic weak bases like CatSper blockers (B) diffuse across the sperm plasma membrane from a region of high concentration to one of low concentration (1). Inside the cell, these compounds are accumulated and protonated (BH+) into the acrosomal lumen (2).
Enrique I. Oliver, Martina Jabloñski, Mariano G. Buffone, Alberto Darszon   +3 more
wiley   +1 more source

Phytobioactive compounds as therapeutic agents for human diseases: A review

Food Science &Nutrition, Volume 11, Issue 6, Page 2500-2529, June 2023., 2023
Phytobioactive compounds are plant secondary metabolites and have remarkable therapeutic potential. Polyphenols, alkaloids, terpenes, and polysaccharides isolated from medicinal plants showed remarkable antioxidant, anticancer, cytotoxic, anti‐inflammatory, cardioprotective, hepatoprotective, immunomodulatory, neuroprotective, and antidiabetic ...
Muhammad Riaz, Ramsha Khalid, Muhammad Afzal, Fozia Anjum, Hina Fatima, Saadiya Zia, Ghulam Rasool, Chukwuebuka Egbuna, Andrew G. Mtewa, Chukwuemelie Zedech Uche, Muhammad Aamir Aslam   +10 more
wiley   +1 more source

Health benefits of microalgae and their microbiomes

Microbial Biotechnology, Volume 15, Issue 7, Page 1966-1983, July 2022., 2022
Microalgae may offer solutions to the societal challenge we face concerning the lack of antibiotics treating the growing level of antimicrobial resistant bacteria and fungi in clinical and industrial settings. While the vast majority of microalgae and their associated microbiota are unstudied, they may be a fascinating and rewarding source for novel ...
Ines Krohn, Simon Menanteau‐Ledouble, Gunhild Hageskal, Yekaterina Astafyeva, Pierre Jouannais, Jeppe Lund Nielsen, Massimo Pizzol, Alexander Wentzel, Wolfgang R. Streit   +8 more
wiley   +1 more source

Synthese von C‐Oligosacchariden via vielseitiger C(sp3)‐H‐Glykosylierung von Glykosiden

Angewandte Chemie, Volume 134, Issue 11, March 7, 2022., 2022
Die Palladium‐katalysierte C(sp3)‐H‐Glykosylierung von Glykosiden wird erschlossen. Diese Saccharid‐Assemblierungsstrategie durch die C(sp3)‐H‐Glykosylierung zeichnet sich durch eine ausgezeichnete Site‐ und Stereoselektivität aus und ermöglicht die effiziente Synthese verschiedener C‐Disacchariden und C‐Trisacchariden.
Jun Wu, Adelina Kopp, Lutz Ackermann
wiley   +1 more source

Critical Review and Conceptual and Quantitative Models for the Transfer and Depuration of Ciguatoxins in Fishes

Toxins, 2021
We review and develop conceptual models for the bio-transfer of ciguatoxins in food chains for Platypus Bay and the Great Barrier Reef on the east coast of Australia.
Michael J. Holmes, Bill Venables, Richard J. Lewis   +2 more
doaj   +1 more source

Synthesis of the WXYZA′ Domain of Maitotoxin [PDF]

Journal of the American Chemical Society, 2010
A synthesis of the WXYZA' domain (7) of the marine neurotoxin maitotoxin (1) is reported. The convergent synthetic strategy involves construction of key building blocks 11 and 12, their coupling, and the elaboration of the resulting ester (10) to the target molecule through a ring-closing metathesis and a hydroxy dithioketal cyclization as the key ...
K C, Nicolaou, Thomas M, Baker, Tsuyoshi, Nakamura   +2 more
openaire   +2 more sources

New insights into maitotoxin action [PDF]

European Journal of Biochemistry, 1988
Maitotoxin (3 ng/mol) induced a massive uptake of 45Ca2+ into BC3H1 cells. This effect exhibits a lag phase of 3 min. Inositol diphosphate formation occurred concomittantly with the 45Ca2+ uptake but inositol monophosphate formation was found only after a 5‐min delay following toxin addition.
F, Sladeczek, B H, Schmidt, R, Alonso, L, Vian, A, Tep, T, Yasumoto, R N, Cory, J, Bockaert   +7 more
openaire   +2 more sources