Results 61 to 70 of about 1,190 (207)
Advanced Healthcare Materials, Volume 14, Issue 23, September 8, 2025.This review highlights recent progress in nanocarriers targeting pattern recognition receptors (PRRs), including Toll‐like and NOD‐like receptors, for enhancing the treatment of bacterial sepsis and related complications. These nanomedicines deliver antibiotics and anti‐inflammatory agents while modulating immune responses.
Eman A. Ismail +3 more
wiley +1 more source
Journal of Osteoporosis, Volume 2012, Issue 1, 2012., 2012 P2X7 receptor‐mediated purinergic signaling is a well‐known mechanism involved in bone remodeling. The P2X7 receptor has been implicated in the pathophysiology of various bone and cartilage diseases, including rheumatoid arthritis (RA), a widespread and complex chronic inflammatory disorder. The P2X7 receptor induces the release into the synovial fluid
Alberto Baroja-Mazo +2 more
wiley +1 more source
Synthesis of the WXYZA′ Domain of Maitotoxin
, 2016 A synthesis of the WXYZA′ domain (7) of the marine neurotoxin maitotoxin (1) is reported. The convergent synthetic strategy involves construction of key building blocks 11 and 12, their coupling, and the elaboration of the resulting ester (10) to the ...
Tsuyoshi Nakamura (1343718) +2 more
core +1 more source
Food Risk Assess Europe, Volume 3, Issue 2, April 2025.Abstract In France, the presence of marine microalgae of the genus Ostreopsis has been identified repeatedly on the Mediterranean coast for several years, whereas on the French Basque coasts its presence is much more recent. In the summers of 2021 and 2022, major Ostreopsis flowering episodes were reported on the Basque coast, resulting in several ...
Rodolphe Lemée +73 more
wiley +1 more source
Role of the Inflammasome, IL‐1β, and IL‐18 in Bacterial Infections
The Scientific World Journal, Volume 11, Issue 1, Page 2037-2050, 2011., 2011 The inflammasome is an important innate immune pathway that regulates at least two host responses protective against infections: (1) secretion of the proinflammatory cytokines IL‐1β and IL‐18 and (2) induction of pyroptosis, a form of cell death. Inflammasomes, of which different types have been identified, are multiprotein complexes containing pattern
Manoranjan Sahoo +4 more
wiley +1 more source
Addressing the safety of new food sources and production systems
Comprehensive Reviews in Food Science and Food Safety, Volume 23, Issue 3, May 2024.Abstract New food sources and production systems (NFPS) are garnering much attention, driven by international trade, changing consumer preferences, potential sustainability benefits, and innovations in climate‐resilient food production systems. However, NFPS can introduce new challenges for food safety agencies and food manufacturers.
Yong Quan Tan +4 more
wiley +1 more source
Maitotoxin-induced liver cell death involving loss of cell ATP following influx of calcium
, 1989 Maitotoxin, one of the most potent marine toxins known, produced cell death in cultures of rat hepatocytes with a TD50 of 80 pm at 24 hr. The cell death, as indicated by a dose- and time-dependent leakage of lactate dehydrogenase (LDH), was also ...
Krishna, Gopal +3 more
core +1 more source
The isolation and purification of a caribbean maitotoxin
, 1994 The phenomenon known as red tide has been a topic of great interest in that there is concern that the scale and complexity of this natural phenomenon are expanding. It is known that the benthic dinoflagellate, Gambierdiscus toxicus, produces a variety of polyether toxins that contaminate seafood and result in human illness.
S E Davis, S M Knoepp, B A Lanoue
openaire +2 more sources
Inhibition of Maitotoxin‐Induced Ca2+ Influx in Rat Glioma C6 Cells by Brevetoxins and Synthetic Fragments of Maitotoxin [PDF]
Journal of Neurochemistry, 1998 Abstract: 45Ca2+ influx in rat glioma C6 cells induced by 0.3 nM maitotoxin (MTX) was markedly inhibited by brevetoxin A (PbTx1) and brevetoxin B (PbTx2), with EC50 values of 16 and 13 µM, respectively. This inhibition was observed immediately after addition of MTX when monitored with fura‐2, which suggests that PbTx2 directly blocks the action of MTX.
K, Konoki +5 more
openaire +2 more sources
Maitotoxin stimulates steroid and peptide hormone secretion by swine luteal tissue
, 1987 The impact of calcium influx on the secretion of steroidal and nonsteroidal ovarian products was tested using a novel marine toxin, maitotoxin, a putative activator of endogenous calcium channels.
K. Yoshida +3 more
core +1 more source