Results 11 to 20 of about 332 (158)

Maitotoxin-4, a Novel MTX Analog Produced by Gambierdiscus excentricus [PDF]

Marine Drugs, 2017
Maitotoxins (MTXs) are among the most potent toxins known. These toxins are produced by epi-benthic dinoflagellates of the genera Gambierdiscus and Fukuyoa and may play a role in causing the symptoms associated with Ciguatera Fish Poisoning.
Francesco Pisapia, Manoëlla Sibat, Christine Herrenknecht, Korian Lhaute, Greta Gaiani, Pierre-Jean Ferron, Valérie Fessard, Santiago Fraga, Silvia M. Nascimento, R. Wayne Litaker, William C. Holland, Catherine Roullier, Philipp Hess   +12 more
doaj   +7 more sources

Targeted Metabolite Fingerprints of Thirteen Gambierdiscus, Five Coolia and Two Fukuyoa Species. [PDF]

Mar Drugs
The genus Gambierdiscus produces an array of bioactive hydrophilic and lipophilic secondary metabolites that range in mode of action and toxicity. In this study, the metabolite fingerprint was mapped for thirteen Gambierdiscus, five Coolia and two ...
Murray JS, Passfield EMF, Rhodes LL, Puddick J, Finch SC, Smith KF, van Ginkel R, Mudge EM, Nishimura T, Funaki H, Adachi M, Prinsep MR, Harwood DT.   +12 more
europepmc   +3 more sources

Cytotoxic and Hemolytic Activities of Extracts of the Fish Parasite Dinoflagellate <i>Amyloodinium ocellatum</i>. [PDF]

Toxins (Basel), 2022
The dinoflagellate Amyloodinium ocellatum is the etiological agent of a parasitic disease named amyloodiniosis. Mortalities of diseased fish are usually attributed to anoxia, osmoregulatory impairment, or opportunistic bacterial infections ...
Moreira M, Soliño L, Marques CL, Laizé V, Pousão-Ferreira P, Costa PR, Soares F.   +6 more
europepmc   +3 more sources

The Formosalides: Structure Determination by Total Synthesis

Angewandte Chemie, Volume 133, Issue 1, Page 450-458, January 4, 2021., 2021
Total synthesis allowed the identification of the most likely stereostructure of the cytotoxic marine macrolides of the formosalide family (see structure) from eight possibilities. The successful route was based upon an inherently flexible blueprint that builds all stereogenic centers by strictly catalyst controlled transformations prior to formation ...
Saskia Schulthoff, James Y. Hamilton, Marc Heinrich, Yonghoon Kwon, Conny Wirtz, Alois Fürstner   +5 more
wiley   +2 more sources

Dereplication of Gambierdiscus balechii extract by LC-HRMS and in vitro assay: First description of a putative ciguatoxin and confirmation of 44-methylgambierone [PDF]

, 2023
: Marine toxins have a significant impact on seafood resources and human health. Up to date, mainly based on bioassays results, two genera of toxic microalgae, Gambierdiscus and Fukuyoa have been hypothesized to produce a suite of biologically active ...
Bodi, Dorina, Capellacci, Samuela, Dell'Aversano, Carmela, Dell’Aversano, Carmela, Loeffler, Christopher R., Miele, Valentina, Monti, Marcello, Penna, Antonella, Spielmeyer, Astrid, Tartaglione, Luciana, Varone, Alessia, Varra, Michela, Varriale, Fabio   +12 more
core   +1 more source

Two‐pore channel 1 and Ca2+ release‐activated Ca2+ channels contribute to the acrosomal pH‐dependent intracellular Ca2+ increase in mouse sperm

The Journal of Physiology, Volume 601, Issue 14, Page 2935-2958, 15 July 2023., 2023
Abstract figure legend Amphipathic weak bases like CatSper blockers (B) diffuse across the sperm plasma membrane from a region of high concentration to one of low concentration (1). Inside the cell, these compounds are accumulated and protonated (BH+) into the acrosomal lumen (2).
Enrique I. Oliver, Martina Jabloñski, Mariano G. Buffone, Alberto Darszon   +3 more
wiley   +1 more source

Maitotoxin: An Inspiration for Synthesis [PDF]

Israel Journal of Chemistry, 2011
AbstractMaitotoxin holds a special place in the annals of natural products chemistry as the largest and most toxic secondary metabolite known to date. Its fascinating, ladder‐like, polyether molecular structure and diverse spectrum of biological activities elicited keen interest from chemists and biologists, who recognized its uniqueness and potential ...
K C, Nicolaou, Robert J, Aversa
openaire   +2 more sources

Phytobioactive compounds as therapeutic agents for human diseases: A review

Food Science &Nutrition, Volume 11, Issue 6, Page 2500-2529, June 2023., 2023
Phytobioactive compounds are plant secondary metabolites and have remarkable therapeutic potential. Polyphenols, alkaloids, terpenes, and polysaccharides isolated from medicinal plants showed remarkable antioxidant, anticancer, cytotoxic, anti‐inflammatory, cardioprotective, hepatoprotective, immunomodulatory, neuroprotective, and antidiabetic ...
Muhammad Riaz, Ramsha Khalid, Muhammad Afzal, Fozia Anjum, Hina Fatima, Saadiya Zia, Ghulam Rasool, Chukwuebuka Egbuna, Andrew G. Mtewa, Chukwuemelie Zedech Uche, Muhammad Aamir Aslam   +10 more
wiley   +1 more source

New insights into maitotoxin action [PDF]

European Journal of Biochemistry, 1988
Maitotoxin (3 ng/mol) induced a massive uptake of 45Ca2+ into BC3H1 cells. This effect exhibits a lag phase of 3 min. Inositol diphosphate formation occurred concomittantly with the 45Ca2+ uptake but inositol monophosphate formation was found only after a 5‐min delay following toxin addition.
F, Sladeczek, B H, Schmidt, R, Alonso, L, Vian, A, Tep, T, Yasumoto, R N, Cory, J, Bockaert   +7 more
openaire   +2 more sources

Health benefits of microalgae and their microbiomes

Microbial Biotechnology, Volume 15, Issue 7, Page 1966-1983, July 2022., 2022
Microalgae may offer solutions to the societal challenge we face concerning the lack of antibiotics treating the growing level of antimicrobial resistant bacteria and fungi in clinical and industrial settings. While the vast majority of microalgae and their associated microbiota are unstudied, they may be a fascinating and rewarding source for novel ...
Ines Krohn, Simon Menanteau‐Ledouble, Gunhild Hageskal, Yekaterina Astafyeva, Pierre Jouannais, Jeppe Lund Nielsen, Massimo Pizzol, Alexander Wentzel, Wolfgang R. Streit   +8 more
wiley   +1 more source