Results 21 to 30 of about 267 (149)
New insights into maitotoxin action [PDF]
European Journal of Biochemistry, 1988 Maitotoxin (3 ng/mol) induced a massive uptake of 45Ca2+ into BC3H1 cells. This effect exhibits a lag phase of 3 min. Inositol diphosphate formation occurred concomittantly with the 45Ca2+ uptake but inositol monophosphate formation was found only after a 5‐min delay following toxin addition.
F, Sladeczek +7 more
openaire +2 more sources
Synthesis of the WXYZA′ Domain of Maitotoxin [PDF]
Journal of the American Chemical Society, 2010 A synthesis of the WXYZA' domain (7) of the marine neurotoxin maitotoxin (1) is reported. The convergent synthetic strategy involves construction of key building blocks 11 and 12, their coupling, and the elaboration of the resulting ester (10) to the target molecule through a ring-closing metathesis and a hydroxy dithioketal cyclization as the key ...
K C, Nicolaou +2 more
openaire +2 more sources
Plesiomonas: A Review on Food Safety, Fish‐Borne Diseases, and Tilapia
The Scientific World Journal, Volume 2021, Issue 1, 2021., 2021 Fish and fish products are considered a fundamental part of the human diet due to their high nutritional value. Food‐borne diseases are considered a major public health challenge worldwide due to their incidence, associated mortality, and negative economic repercussions. Food safety is the guarantee that foods will not cause harm to the health of those
Alejandro De Jesús Cortés-Sánchez +4 more
wiley +1 more source
Synthesis of the ABCDEFG Ring System of Maitotoxin [PDF]
Journal of the American Chemical Society, 2010 Maitotoxin (1) continues to fascinate scientists not only because of its size and potent neurotoxicity but also due to its molecular architecture. To provide further support for its structure and facilitate fragment-based biological studies, we developed an efficient chemical synthesis of the ABCDEFG segment 3 of maitotoxin.
K C, Nicolaou +3 more
openaire +2 more sources
Synthesis of the C′D′E′F′ Domain of Maitotoxin [PDF]
Journal of the American Chemical Society, 2010 A devised biomimetic strategy toward the C'D'E'F' domain (6) of maitotoxin (1) led to hydroxy triepoxide 8 as a postulated polyepoxide precursor. However, all attempts to induce the desired cascade to form the targeted compound through a zip-type reaction under neutral or acidic conditions failed, prompting adoption of a linear stepwise approach to 6 ...
K C, Nicolaou +3 more
openaire +2 more sources
Complete Structure of Maitotoxin.
Journal of Synthetic Organic Chemistry, Japan, 1997 Maitotoxin (MTX, 1) is the most toxic and largest non-biopolymer known to date. The complete structural determination of MTX including the absolute configuration has been achieved recently. The relative configurations of the four acyclic portions (C1-C15, C35-C39, C63-C68, and C134-C142) were elucidated by (1) the extensive configurational analysis ...
SASAKI, Makoto, MURATA, Michio
openaire +3 more sources
Intraspecific Variability in the Toxin Production and Toxin Profiles of In Vitro Cultures of Gambierdiscus polynesiensis (Dinophyceae) from French Polynesia. [PDF]
Toxins (Basel), 2019 Ciguatera poisoning (CP) is a foodborne disease caused by the consumption of seafood contaminated with ciguatoxins (CTXs) produced by dinoflagellates in the genera Gambierdiscus and Fukuyoa.
Longo S +5 more
europepmc +2 more sources
Synthesis and Biological Evaluation of QRSTUVWXYZA′ Domains of Maitotoxin [PDF]
Journal of the American Chemical Society, 2014 The synthesis of QRSTUVWXYZA' domains 7, 8, and 9 of the highly potent marine neurotoxin maitotoxin (1), the largest secondary metabolite isolated to date, is described. The devised synthetic strategy entailed a cascade Takai-Utimoto ester olefination/ring closing metathesis to construct ring Y, a hydroxydithioketal cyclization/methylation sequence to ...
Nicolaou, K.C. +5 more
openaire +3 more sources
Maitotoxin-4, a Novel MTX Analog Produced by Gambierdiscus excentricus
Marine Drugs, 2017 Maitotoxins (MTXs) are among the most potent toxins known. These toxins are produced by epi-benthic dinoflagellates of the genera Gambierdiscus and Fukuyoa and may play a role in causing the symptoms associated with Ciguatera Fish Poisoning.
Francesco Pisapia +12 more
doaj +1 more source
Polyketide synthesis genes associated with toxin production in two species of Gambierdiscus (Dinophyceae). [PDF]
BMC Genomics, 2015 Background: Marine microbial protists, in particular, dinoflagellates, produce polyketide toxins with ecosystem-wide and human health impacts. Species of Gambierdiscus produce the polyether ladder compounds ciguatoxins and maitotoxins, which can lead to ...
Kohli GS +7 more
europepmc +2 more sources