Results 31 to 40 of about 267 (149)

Maitotoxin, a potent, general activator of phosphoinositide breakdown [PDF]

FEBS Letters, 1989
Maitotoxin (MTX), a potent marine toxin, elicits a calcium‐dependent activation of cells that can be inhibited by calcium channel blockers like nifedipine. MTX also stimulates phosphoinositide breakdown in smooth muscle cells, NCB‐20 cells and PC12 cells through a nifedipine‐insensitive mechanism.
Gusovsky, Fabian, Yasumoto, Takeshi, Daly, John W.   +2 more
openaire   +2 more sources

NLRP3: A Novel Mediator in Cardiovascular Disease

Journal of Immunology Research, Volume 2018, Issue 1, 2018., 2018
Cardiovascular disease is a major cause of death worldwide. Inflammasome infiltration has been identified to play a central role in the pathological progression of certain cardiovascular diseases, such as vascular damage spanning atherosclerosis, aneurysm, or arteritis; ischemic heart disease; and other nonischemic heart diseases including diabetic ...
Wenyi Zhou, Chunyuan Chen, Zhiheng Chen, Lin Liu, Jie Jiang, Zhixiang Wu, Mingyi Zhao, Yanfang Chen, Diana Velluto   +8 more
wiley   +1 more source

Chemical diversity in the genus Gambierdiscus, with a focus on Ciguatoxins and Maitotoxins

, 2017
The genus Gambierdiscus is a complex and diverse group of marine dinoflagellates that produce a range of bioactive compounds, including ciguatoxins and maitotoxins.
Pisapia, Francesco, Herrencknecht, Christine, Nishimura, T., Sibat, Manoëlla, Ferron, Pierre-Jean, Hess, Philipp, Lhaute, Korian, Fraga, Santiago, Adachi, Masao, Séchet, Véronique, Nascimento, Silvia M., Holland, William Chris, Fessard, Valérie, Roullier, Catherine, Watanabe, Ryuichi, Litaker, Richard Wayne, Suzuki, T.   +16 more
core   +1 more source

Dereplication of Gambierdiscus balechii extract by LC-HRMS and in vitro assay: First description of a putative ciguatoxin and confirmation of 44-methylgambierone [PDF]

, 2023
Marine toxins have a significant impact on seafood resources and human health. Up to date, mainly based on bioassays results, two genera of toxic microalgae, Gambierdiscus and Fukuyoa have been hypothesized to produce a suite of biologically active ...
Varriale F., Varone A., Penna A., Dell’Aversano C., Miele V., Tartaglione L., Varra M., Monti M., Loeffler C., Bodi D., Spielmeyer A., Capellacci S.   +11 more
core   +3 more sources

Cell Death‐Associated Molecular‐Pattern Molecules: Inflammatory Signaling and Control

Mediators of Inflammation, Volume 2014, Issue 1, 2014., 2014
Apoptosis, necroptosis, and pyroptosis are different cellular death programs characterized in organs and tissues as consequence of microbes infection, cell stress, injury, and chemotherapeutics exposure. Dying and death cells release a variety of self‐proteins and bioactive chemicals originated from cytosol, nucleus, endoplasmic reticulum, and ...
Beatriz Sangiuliano, Nancy Marcela Pérez, Dayson F. Moreira, José E. Belizário, Victor M. Baizabal-Aguirre   +4 more
wiley   +1 more source

[Retracted] Genetic and Functional Profiling of Crohn′s Disease: Autophagy Mechanism and Susceptibility to Infectious Diseases

BioMed Research International, Volume 2013, Issue 1, 2013., 2013
Crohn′s disease is a complex disease in which genome, microbiome, and environment interact to produce the immunological background of the disease. Disease in childhood is more extensive and characterized by a rapid progression, leading to severe repercussions in the course of the disorder.
Annalisa Marcuzzi, Anna Monica Bianco, Martina Girardelli, Alberto Tommasini, Stefano Martelossi, Lorenzo Monasta, Sergio Crovella, Enrique Medina-Acosta   +7 more
wiley   +1 more source

A common response to common danger? Comparison of animal and plant signaling pathways involved in cadmium sensing

Journal of Cell Communication and Signaling, Volume 6, Issue 4, Page 191-204, December 2012., 2012
Abstract Exposure to cadmium results in disturbances in cell homeostasis in all living organisms. The first response to stress factors, including cadmium, is activation of signal transduction pathways that mobilize cell defense mechanisms. The aim of this review is a comparison between the signaling network triggered by Cd in plants and animals ...
Jagna Chmielowska‐Bąk, Joanna Deckert
wiley   +1 more source

Nanocarrier‐Based Targeting of Pattern Recognition Receptors as an Innovative Strategy for Enhancing Sepsis Therapy

Advanced Healthcare Materials, Volume 14, Issue 23, September 8, 2025.
This review highlights recent progress in nanocarriers targeting pattern recognition receptors (PRRs), including Toll‐like and NOD‐like receptors, for enhancing the treatment of bacterial sepsis and related complications. These nanomedicines deliver antibiotics and anti‐inflammatory agents while modulating immune responses.
Eman A. Ismail, Vincent O. Nyandoro, Calvin A. Omolo, Thirumala Govender   +3 more
wiley   +1 more source

Modulating P2X7 Receptor Signaling during Rheumatoid Arthritis: New Therapeutic Approaches for Bisphosphonates

Journal of Osteoporosis, Volume 2012, Issue 1, 2012., 2012
P2X7 receptor‐mediated purinergic signaling is a well‐known mechanism involved in bone remodeling. The P2X7 receptor has been implicated in the pathophysiology of various bone and cartilage diseases, including rheumatoid arthritis (RA), a widespread and complex chronic inflammatory disorder. The P2X7 receptor induces the release into the synovial fluid
Alberto Baroja-Mazo, Pablo Pelegrín, Niklas Rye Jørgensen   +2 more
wiley   +1 more source

Opinion of the French Agency for Food, Environmental and Occupational Health & Safety (ANSES) on the risks to human health associated with the proliferation of Ostreopsis spp. on the Basque coast

Food Risk Assess Europe, Volume 3, Issue 2, April 2025.
Abstract In France, the presence of marine microalgae of the genus Ostreopsis has been identified repeatedly on the Mediterranean coast for several years, whereas on the French Basque coasts its presence is much more recent. In the summers of 2021 and 2022, major Ostreopsis flowering episodes were reported on the Basque coast, resulting in several ...
Rodolphe Lemée, Jean‐François Humbert, Eric Abadie, Zouher Amzil, Elisa Berdalet, Ronel Biré, Marie‐Yasmine Dechraoui Bottein, Luc de Haro, Nicolas Delcourt, Valérie Fessard, Jean‐Philippe Jaeg, César Mattei, Anne Oppliger, Anne‐Sophie Pavaux, Eva Ternon, Gilles Bornert, Anne Togola, Jean Baron, Jean‐Luc Boudenne, Nicolas Cimetiere, Bruno Coulomb, Christophe Dagot, Sabine Denooz, Isabelle Dublineau, Frédéric Feder, Matthieu Fournier, Stéphane Garnaud‐Corbel, Nathalie Garrec, Johnny Gasperi, Julio Gonçalvès, Jean‐Louis Gonzalez, Olivier Horner, Michel Joyeux, Jérôme Labanowski, Sophie Lardy‐Fontan, Françoise Lucas, Christophe Mechouk, Laurent Moulin, Damien Mouly, Fabienne Petit, Catherine Quiblier, Pauline Rousseau‐Gueutin, Marie‐Pierre Sauvant‐Rochat, Michèle Tremblay, Bruno Le Bizec, Marie‐Louise Scippo, Pierre‐Marie Badot, Marie‐Yasmine Bottein, Rachida Chekri, Christine Demeilliers, Virginie Desvignes, Erwan Engel, Gautier Eppe, Anne‐Sophie Ficheux, Eric Houdeau, Emilie Lance, Olivier Laprevote, Michel Laurentie, Ludovic Le Hegarat, Jean‐Charles Leblanc, Nicolas Loiseau, David Makowski, Francesca Mancini, Eric Marchioni, Jean‐François Masfaraud, Mathilde Munier, Isabelle Oswald, Anne Platel, Yann Sivry, Paule Vasseur, Estelle Checlair‐Westerberg, Eléonore Ney, Nathalie Arnich, Carole Catastini   +73 more
wiley   +1 more source