Results 31 to 40 of about 668,342 (306)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Physiological Characteristic Changes and Transcriptome Analysis of Maize (Zea mays L.) Roots under Drought Stress

International Journal of Genomics
Water deficit is a key limiting factor for limiting yield in maize (Zea mays L.). It is crucial to elucidate the molecular regulatory networks of stress tolerance for genetic enhancement of drought tolerance.
Chenglin Zou, Hua Tan, Kaijian Huang, Ruining Zhai, Meng Yang, Aihua Huang, Xinxing Wei, Runxiu Mo, Faqian Xiong   +8 more
doaj   +1 more source

COMPETITIVE ABILITY OF MAIZE IN MIXTURE WITH CLIMBING BEAN IN ORGANIC FARMING [PDF]

, 2005
Intercropped crops represent an important production system in organic farming, especially maize/climbing bean mixture due to its high content of protein in bean seeds for human diet, and producing silage for ruminants.
Bavec, Franc, Bavec, Martina, Grobelnik Mlakar, Silva, Radics, Laszlo, Živec, Urška   +4 more
core  

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Gender and innovation processes in maize-based systems [PDF]

, 2020
This MAIZE report offers a panorama of the gender dimensions of local agricultural innovation processes in the context of maize-based farming systems and ...
Badstue, Lone B., Farnworth, Cathy R., Petesch, Patti, Umantseva, A., Williams, G.   +4 more
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

High-throughput method for ear phenotyping and kernel weight estimation in maize using ear digital imaging

Plant Methods, 2018
Background Grain yield, ear and kernel attributes can assist to understand the performance of maize plant under different environmental conditions and can be used in the variety development process to address farmer’s preferences.
R. Makanza, M. Zaman-Allah, J. E. Cairns, J. Eyre, J. Burgueño, Ángela Pacheco, C. Diepenbrock, C. Magorokosho, A. Tarekegne, M. Olsen, B. M. Prasanna   +10 more
doaj   +1 more source

Low-N stress tolerant maize hybrids have higher fertilizer N recovery efficiency and reduced N-dilution in the grain compared to susceptible hybrids under low N conditions

Plant Production Science, 2020
Developing high yielding maize (Zea mays L.) varieties that have relatively high grain protein content under low nitrogen stress is critical to ensure food and nutrition security in sub-Saharan Africa. This study evaluated the efficiency for fertilizer N
Chisaka Arisede, Zaman-Allah Mainassara, Cairns Jill, Tarekegne Amsal, Magorokosho Cosmos, Das Bish, Masuka Benhildah, Olsen Mike, Prasanna B. Maruthi   +8 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source