Results 31 to 40 of about 157,405 (268)

Genome wide association analysis for yield related traits in maize

BMC Plant Biology, 2022
Background Understanding the genetic basis of yield related traits contributes to the improvement of grain yield in maize. Results Using 291 excellent maize inbred lines as materials, six yield related traits of maize, including grain yield per plant ...
Tingru Zeng, Zhaodong Meng, Runqing Yue, Shouping Lu, Wenlan Li, Wencai Li, Hong Meng, Qi Sun   +7 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Low-N stress tolerant maize hybrids have higher fertilizer N recovery efficiency and reduced N-dilution in the grain compared to susceptible hybrids under low N conditions

Plant Production Science, 2020
Developing high yielding maize (Zea mays L.) varieties that have relatively high grain protein content under low nitrogen stress is critical to ensure food and nutrition security in sub-Saharan Africa. This study evaluated the efficiency for fertilizer N
Chisaka Arisede, Zaman-Allah Mainassara, Cairns Jill, Tarekegne Amsal, Magorokosho Cosmos, Das Bish, Masuka Benhildah, Olsen Mike, Prasanna B. Maruthi   +8 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Evaluation of saline tolerance at the seedling stage of various maize cross combinations

Vietnam Journal of Science, Technology and Engineering, 2017
This study was conducted at the Maize Research Institute of Vietnam using 24 maize hybrids, identified as STM1 to STM24, at five different salt concentrations, which were 0, 50, 100, 150, and 200 mM NaCl.
Huu Hung Nguyen, Van Vang Luong, Thi Minh Tam Ngo, Hoai Son Vu, Xuan Thang Nguyen   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Characterization and functional analysis of conserved non-coding sequences among poaceae: insights into gene regulation and phenotypic variation in maize

BMC Genomics
Background Conserved non-coding sequences (CNS) are islands of non-coding sequences conserved across species and play an important role in regulating the spatiotemporal expression of genes.
Yi Luo, Hang Zhai, Xiu Zhong, Bo Yang, Yang Xu, Tianhong Liu, Qi Wang, Yang Zhou, Yan Mao, Yaxi Liu, Qi Tang, Yanli Lu, Yao Wang, Jie Xu   +13 more
doaj   +1 more source

Weediness and grain yield of specialty maize hybrids cultivated with the application of ecological fertilisers [PDF]

Selekcija i Semenarstvo, 2018
Maize hybrids (Zea mays L.) with specific traits, such as those with red pericarp, high-protein flints or white kernel hybrids, have increased utility value as they contain some vitamins and minerals beneficial to human and animal nutrition. Furthermore,
Simić Milena, Dragičević Vesna, Brankov Milan, Vančetović Jelena, Filipović Milomir, Srdić Jelena   +5 more
doaj  

Combined Transcriptome and Proteome Analysis of Maize (Zea mays L.) Reveals A Complementary Profile in Response to Phosphate Deficiency

Current Issues in Molecular Biology, 2021
A deficiency in the macronutrient phosphate (Pi) brings about various changes in plants at the morphological, physiological and molecular levels.
Zhi Nie, Bowen Luo, Xiao Zhang, Ling Wu, Dan Liu, Jialei Guo, Xuan He, Duojiang Gao, Shiqiang Gao, Shibin Gao   +9 more
doaj   +1 more source