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Major depressive disorder [PDF]
Nature Reviews Disease Primers, 2016 Major depressive disorder (MDD) is a debilitating disease that is characterized by depressed mood, diminished interests, impaired cognitive function and vegetative symptoms, such as disturbed sleep or appetite. MDD occurs about twice as often in women than it does in men and affects one in six adults in their lifetime.
Stefan M. Gold +8 more
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Major Depressive Disorder [PDF]
Neuron, 2000 In summary, MDD is a highly prevalent major medical whose pathophysiology is still poorly understood. MDD is often recurrent or chronic, and evidence suggests that genetic factors partially influence overall risk of illness but also influence the sensitivity of individuals to the depressogenic effects of environmental adversity.
Maurizio Fava, Kenneth S. Kendler
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Lipidomics in Major Depressive Disorder [PDF]
Frontiers in Psychiatry, 2018 Omic sciences coupled with novel computational approaches such as machine intelligence offer completely new approaches to major depressive disorder (MDD) research. The complexity of MDD's pathophysiology is being integrated into studies examining MDD's biology within the omic fields.
Andreas Walther +7 more
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Temperament and major depressive disorder [PDF]
Annals of General Psychiatry, 2010 The Lebanese-Arabic TEMPS-A (Temperament Evaluation of the Memphis, Pisa, Paris and San Diego Autoquestionnaire) was used to assess the association between affective temperament and mental disorders in a nationally representative sample of the Lebanese Evaluation of the Burden of Ailments and Needs Of the Nation study(L.E.B.A.N.O.N). The five affective
Zeina Mneimneh +8 more
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Neurobiology of Major Depressive Disorder [PDF]
Neural Plasticity, 2013 We survey studies which relate abnormal neurogenesis to major depressive disorder. Clinically, descriptive gene and protein expression analysis and genetic and functional studies revised here show that individual alterations of a complex signaling network, which includes the hypothalamic-pituitary-adrenal axis; the production of neurotrophins and ...
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SUMOylation and Major Depressive Disorder
International Journal of Molecular Sciences, 2022 Since the discovery of the small ubiquitin-like modifier (SUMO) protein in 1995, SUMOylation has been considered a crucial post-translational modification in diverse cellular functions. In neurons, SUMOylation has various roles ranging from managing synaptic transmitter release to maintaining mitochondrial integrity and determining neuronal health.
Seok-Won Jeoung +5 more
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Epigenetic prediction of major depressive disorder [PDF]
Molecular Psychiatry, 2020 AbstractVariation in DNA methylation (DNAm) is associated with lifestyle factors such as smoking and body mass index (BMI) but there has been little research exploring its ability to identify individuals with major depressive disorder (MDD). Using penalised regression on genome-wide CpG methylation, we tested whether DNAm risk scores (MRS), trained on ...
Ian J. Deary +13 more
openaire +7 more sources
Advanced Chinese Medicine, EarlyView.Abstract The NLR family pyrin domain‐containing 3 (NLRP3) inflammasome is a vital part of the innate immune response, whilst its aberrant activation drives the progression of several noncommunicable diseases. It induces caspase‐1 activation and the downstream substrates involved with the processing and secretion of the pro‐inflammatory cytokines IL‐1β ...
Yucen Zou +6 more
wiley +1 more source
Advanced Chinese Medicine, EarlyView.Therapeutic properties of thymoquinone. Abstract In this review, a comprehensive and systematic evaluation of the phytochemical constituents, traditional medicinal applications, current pharmacological research, toxicity, and nanobiotechnology of black cumin has been undertaken.
Raghvendra Pandey +2 more
wiley +1 more source