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Major depressive disorder [PDF]

Nature Reviews Disease Primers, 2016
Major depressive disorder (MDD) is a debilitating disease that is characterized by depressed mood, diminished interests, impaired cognitive function and vegetative symptoms, such as disturbed sleep or appetite. MDD occurs about twice as often in women than it does in men and affects one in six adults in their lifetime.
Otte, Christian, Gold , Stefan M., Penninx, Brenda W., Pariante, Carmine Maria, Etkin, Amit, Fava, Maurizio, C. Mohr, David, Schatzberg , Alan   +7 more
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Major Depressive Disorder [PDF]

Neuron, 2000
In summary, MDD is a highly prevalent major medical whose pathophysiology is still poorly understood. MDD is often recurrent or chronic, and evidence suggests that genetic factors partially influence overall risk of illness but also influence the sensitivity of individuals to the depressogenic effects of environmental adversity.
Fava, Maurizio, Kendler, Kenneth S
openaire   +2 more sources

Treating depressive disorders with the unified protocol: A preliminary randomized evaluation. [PDF]

, 2020
OBJECTIVES: This study aims to examine the efficacy of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP) for individuals diagnosed with a depressive disorder. METHOD: Participants included 44 adults who met criteria for major
Ametaj, Amantia A., Barlow, David H., Bentley, Kate H., Cardona, Nicole, Farchione, Todd J., Nauphal, Maya, Sauer-Zavala, Shannon, Steele, Stephanie Jarvi, Tirpak, Julianne Wilner, Wang, Mengxing   +9 more
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Microstructural Correlates of Resilience against Major Depressive Disorder: Epigenetic Mechanisms? [PDF]

, 2010
Mental disorders are a major cause of long-term disability and are a direct cause of mortality, with approximately 800.000 individuals dying from suicide every year worldwide - a high proportion of them related to major depressive disorder (MDD)^1 ...
Andrew Fagan, Angela Carballedo, Danusia Lisiecka, Dermot Kelleher, Ian Daly, James Meaney, Thomas Frodl, Thomas Frodl, Yolande Ferguson   +8 more
core   +3 more sources

Comorbid depressive disorders in ADHD. the role of ADHD severity, subtypes and familial psychiatric disorders [PDF]

, 2014
ObjectiveaaTo evaluate the presence of Major Depressive Disorder (MDD) and Dysthymic Disorder (DD) in a sample of Italian children with Attention Deficit Hyperactivity Disorder (ADHD) and to explore specific features of comorbid depressive disorders in ...
Andriola E, Di Roma F, DI TRANI, MICHELA, Donfrancesco R., Leone D, Miano S, PARISI, Pasquale   +6 more
core   +1 more source

Lipidomics in Major Depressive Disorder [PDF]

Frontiers in Psychiatry, 2018
Omic sciences coupled with novel computational approaches such as machine intelligence offer completely new approaches to major depressive disorder (MDD) research. The complexity of MDD's pathophysiology is being integrated into studies examining MDD's biology within the omic fields.
Andreas Walther, Carlo Vittorio Cannistraci, Carlo Vittorio Cannistraci, Kai Simons, Claudio Durán, Mathias J. Gerl, Susanne Wehrli, Clemens Kirschbaum   +7 more
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Sensor-AssistedWeighted Average Ensemble Model for Detecting Major Depressive Disorder [PDF]

, 2019
The present methods of diagnosing depression are entirely dependent on self-report ratings or clinical interviews. Those traditional methods are subjective, where the individual may or may not be answering genuinely to questions.
Chang, Chuan-Yu, Gao, Liang, Garg, Akhil, Gutiérrez Reina, Daniel, Mahendran, Nivedhitha, Srinivasan, Kathiravan, Vincent, Durai Raj   +6 more
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SUMOylation and Major Depressive Disorder

International Journal of Molecular Sciences, 2022
Since the discovery of the small ubiquitin-like modifier (SUMO) protein in 1995, SUMOylation has been considered a crucial post-translational modification in diverse cellular functions. In neurons, SUMOylation has various roles ranging from managing synaptic transmitter release to maintaining mitochondrial integrity and determining neuronal health.
Seok-Won Jeoung, Hyun-Sun Park, Zae Young Ryoo, Dong-Hyung Cho, Hyun-Shik Lee, Hong-Yeoul Ryu   +5 more
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Severity of Depressive Symptoms and Accuracy of Dietary Reporting among Obese Women with Major Depressive Disorder Seeking Weight Loss Treatment [PDF]

, 2014
An elevation in symptoms of depression has previously been associated with greater accuracy of reported dietary intake, however this association has not been investigated among individuals with a diagnosis of major depressive disorder.
AJ Moshfegh, Andrew M. Busch, B Olendzki, Barbara C. Olendzki, Bradley M. Appelhans, CA Blanton, DA Cole, E Archer, FN Jacka, FS Luppino, Ira S. Ockene, J Tanakamatsumi, JA Linde, JA Tooze, Jerson Laks, Jessica L. Oleski, K Dobson, KD Strosahl, Kristin L. Schneider, L De Wit, LB Alloy, LE Burke, M Hamilton, M Yannakoulia, M Yannakoulia, MA Mendez, Matthew C. Whited, Michele A. DeBiasse, MJ Kretsch, Molly E. Waring, P Rohde, Philip A. Merriam, RC Kessler, RJ Hill, RR Briefel, S Pagoto, Sherry L. Pagoto, SJ Adams, Stephenie C. Lemon, Sybil L. Crawford, TN Akbaraly, Y Ma, Yunsheng Ma   +42 more
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Failure of hippocampal deactivation during loss events in treatment-resistant depression [PDF]

, 2015
Major depressive disorder is characterized by anhedonia, cognitive biases, ruminations, hopelessness and increased anxiety. Blunted responses to rewards have been reported in a number of recent neuroimaging and behavioural studies of major depressive ...
Blair A. Johnston, Cavanagh, David Christmas, J. Douglas Steele, Keith Matthews, Ma, Serenella Tolomeo, Victoria Gradin, Zhang   +8 more
core   +2 more sources