Gene duplication and fragmentation in the zebra finch major histocompatibility complex
BMC Biology, 2010 Background Due to its high polymorphism and importance for disease resistance, the major histocompatibility complex (MHC) has been an important focus of many vertebrate genome projects. Avian MHC organization is of particular interest because the chicken
Burt David W +10 more
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Assignment of the major histocompatibility complex to a region of the short arm of human chromosome 6 [PDF]
, 1977 openalex +1 more source
Advanced Cancer Immunotherapy via SMARCAL1 Blockade Using a Glucose‐Responsive CRISPR Nanovaccine
Advanced Science, EarlyView.A glucose‐catalyzed chemodynamic strategy is proposed to activate therapeutic genome editing of SMARCAL1to improve cancer immunotherapy. This innovative design featuring Fenton reaction activity and glucose consumption ability, not only effectively synergizes to activate the cGAS‐STING pathway but also inhibits the opposing functions of interferon by ...
Yuwei Li +8 more
wiley +1 more source
The Molecular Perspective: Major Histocompatibility Complex [PDF]
The Oncologist, 2005 Abstract Learning Objectives After completing this course, the reader will be able to: Describe the role of major histocompatibility complex (MHC) in viral infection and cancer. Access and take the CME test online and receive 1 hour of AMA PRA category 1 credit at ...
openaire +4 more sources
Expression of a single major histocompatibility complex locus controls the immune complex locus controls the immune response to poly-L-(tyrosine, glutamic acid)-poly-DL-alanine--poly-L-lysine [PDF]
, 1978 BD Deak, Daniel Meruelo, H O McDevitt
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Advanced Science, EarlyView.Plant‐derived bioactive molecules with low solubility and permeability induce hepatocyte injury, though the mechanisms driving their hepatic effects remain poorly understood. This study identifies a novel transport pathway in which poorly soluble indirubin accumulates in the liver via macrophage‐mediated uptake in Peyer's patches, exacerbating hepatic ...
Yiqi Xu +9 more
wiley +1 more source
Scientific Reports, 2017 The multi-subunit CCR4 (carbon catabolite repressor 4)-NOT (Negative on TATA) complex serves as a central coordinator of all different steps of eukaryotic gene expression.
Alfonso Rodríguez-Gil +9 more
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Genomic Diversity of the Major Histocompatibility Complex in Health and Disease
Cells, 2019 The human Major Histocompatibility Complex (MHC) genes are part of the supra-locus on chromosome 6p21 known as the human leukocyte antigen (HLA) system [...]
Jerzy K. Kulski +2 more
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Binding of purified, soluble major histocompatibility complex polypeptide chains onto isolated T-cell receptors. I. Reactivity against allo- and self-determinants. [PDF]
, 1979 Hans Binz +4 more
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Identification of a CD4+ T cell-stimulating antigen of pathogenic bacteria by expression cloning. [PDF]
, 1995 Identifying the immunogenic proteins that elicit pathogen-specific T cell responses is key to rational vaccine design. While several approaches have succeeded in identifying major histocompatibility complex (MHC) class I bound peptides that stimulate CD8+
Campbell, D +2 more
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