Results 81 to 90 of about 102,809 (247)

Major Histocompatibility Complex

Russian journal of immunology : RJI : official journal of Russian Society of Immunology
At the 2nd Congress of Russian Immunologists, which is holding at the boundary not only two centuries, but and millennia, we had to present views, how the knowledge about major histocompatibility system has been changed (better to say has been progressed) for the brief historical period (50-60 years). 1.
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Changes in blood lymphocyte subpopulations and expression of MHC-II molecules in wild mares before and after parturition

Journal of Veterinary Research, 2017
Introduction: Pregnancy is a physiological state in which the immune system undergoes certain changes. On the one hand, by depleting cell defence mechanisms, it favours development and maintenance of the pregnancy.
Krakowski Leszek, Bartoszek Przemysław, Krakowska Izabela, Stachurska Anna, Piech Tomasz, Brodzki Piotr, Wrona Zygmunt   +6 more
doaj   +1 more source

Allelic variation in HLA-B and HLA-C sequences and the evolution of the HLA-B alleles [PDF]

, 1989
Several new HLA-B (B8, B51, Bw62)- and HLA-C (Cw6, Cw7)-specific genes were isolated either as genomic cosmid or cDNA clones to study the diversity of HLA antigens.
Doerner, C., Kuon, W., Pohla, Heike, Tabaczewski, P., Weiss, Elisabeth H.   +4 more
core   +1 more source

TRAP5 Inhibition Targeting Scar‐Associated Macrophages Ameliorates Acute Kidney Injury to Chronic Kidney Disease Transition

Advanced Science, EarlyView.
This study delineates macrophage heterogeneity along the acute kidney injury to chronic kidney disease transition. Single‐cell RNA sequencing reveals a TRAP5+ scar‐associated macrophage subset driven by Spp1–Cd44 signaling and mitochondrial metabolic reprogramming.
Chenxi Wang, Yaodong Gu, Wen Du, Lin Xie, Jinwei Quan, Yu Zhao, Ye Cheng, Zhaonan Wei, Yuanyuan Sha, Yi Wang, Dechao Xu, Xiang Gao, Min Chen, Xiangchen Gu   +13 more
wiley   +1 more source

Carbohydrate moieties of major histocompatibility complex class I alloantigens are not required for their recognition by T lymphocytes. [PDF]

, 1985
The ability to generate specific cytotoxic responses using purified major histocompatibility complex (MHC) antigen in liposomes has made it possible to directly assess the importance of class I carbohydrate moieties in T cell recognition of alloantigen ...
Goldstein, SA, Mescher, MF
core  

Cryptic MHC Polymorphism Revealed but Not Explained by Selection on the Class IIB Peptide-Binding Region [PDF]

, 2012
The immune genes of the major histocompatibility complex (MHC) are characterized by extraordinarily high levels of nucleotide and haplotype diversity. This variation is maintained by pathogen-mediated balancing selection that is operating on the peptide ...
Barcaccia, Barson, C. van Oosterhout, Castric, Cvitanich, Eimes, Ellegren, Fraser, Fraser, Fraser, Gibbs, Hughes, Hughes, Hughes, Hughes, Jensen, Kanagawa, Li, M. McMullan, Martin, Mehta, Mona, Nei, Piertney, Posada, Smith, Spurgin, Stone, Uyenoyama, Uyenoyama, V. Llaurens, van Oosterhout, Willing   +32 more
core   +1 more source

O‐GlcNAcylated TAP1 Impairs Antigen Presentation and Promotes Immune Evasion in Bladder Cancer

Advanced Science, EarlyView.
This article unveils a critical mechanism of immune evasion in bladder cancer, which the O‐GlcNAc modification of TAP1 disrupts antigen presentation. This modification triggers HLA‐A degradation, shielding tumor cells from CD8+ T cell attack. The findings highlight targeting this pathway as a promising therapeutic avenue to sensitize tumors to ...
Jinpeng Wu, Xueting Ren, Zhen Zhai, Lu Wang, Liang Liang, Zengqi Tan, Jiazhen Zhao, Yuxuan Han, Yuhan Li, Feng Guan, Xiang Li   +10 more
wiley   +1 more source

CD11b+CD43hiLy6Clo splenocyte‐derived macrophages exacerbate liver fibrosis via spleen–liver axis

Hepatology, EarlyView., 2022
A population of splenic monocytes migrate into the liver and shift to macrophages, which account for the exacerbation of liver fibrosis. Abstract Background and Aims Monocyte‐derived macrophages (MoMFs), a dominant population of hepatic macrophages under inflammation, play a crucial role in liver fibrosis progression.
Shaoying Zhang, Dan Wan, Mengchen Zhu, Guihu Wang, Xurui Zhang, Na Huang, Jian Zhang, Chongyu Zhang, Qi Shang, Chen Zhang, Xi Liu, Fanfan Liang, Chunyan Zhang, Guangyao Kong, Jing Geng, Libo Yao, Shemin Lu, Yongyan Chen, Zongfang Li   +18 more
wiley   +1 more source

Discovery of a Novel MHC Class I Lineage in Teleost Fish which Shows Unprecedented Levels of Ectodomain Deterioration while Possessing an Impressive Cytoplasmic Tail Motif

Cells, 2019
A unique new nonclassical MHC class I lineage was found in Teleostei (teleosts, modern bony fish, e.g., zebrafish) and Holostei (a group of primitive bony fish, e.g., spotted gar), which was designated “H” (from “hexa”) for being ...
Unni Grimholt, Kentaro Tsukamoto, Keiichiro Hashimoto, Johannes M. Dijkstra   +3 more
doaj   +1 more source

Serafino Zappacosta: An Enlightened Mentor and Educator. [PDF]

, 2020
With this article, the authors aim to honor the memory of Serafino Zappacosta, who had been their mentor during the early years of their career in science.
Carbone, Ennio, D'Oro, Ugo, De Felice, Mario, Di Rosa, Francesca, Fontana, Silvia, La Cava, Antonio, Maio, Michele, Matarese, Giuseppe, Racioppi, Luigi, Ruggiero, Giuseppina, Terrazzano, Giuseppe   +10 more
core   +1 more source