Results 141 to 150 of about 991,100 (420)
Hepatology, EarlyView., 2022 Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog +12 more
wiley +1 more source
Major histocompatibility complex B variability in Korean native chicken breeds
Poultry Science, 2020 Adaptive genetic variations have direct influences on the fitness traits of the animal. The major histocompatibility complex B (MHC-B) region is responsible for adaptive and innate immune responses in chickens.
Prabuddha Manjula +3 more
doaj
Scientific Reports, 2017 The multi-subunit CCR4 (carbon catabolite repressor 4)-NOT (Negative on TATA) complex serves as a central coordinator of all different steps of eukaryotic gene expression.
Alfonso Rodríguez-Gil +9 more
doaj +1 more source
Characterization of Major Histocompatibility Complex Genes in Jungle Fowls, Genus Gallus
The Journal of Poultry Science, 2003 Chicken major histocompatibility complex (Mhc) is smaller in size and contains fewer genes than does mammal Mhc. To clarify the characters of Mhc genes in junglefowls as the ancestral species of domestic chickens, we analyzed their Mhc class I B-F and ...
Masahide Nishibori +2 more
doaj +1 more source
BOOST: A fast approach to detecting gene-gene interactions in genome-wide case-control studies [PDF]
arXiv, 2010 Gene-gene interactions have long been recognized to be fundamentally important to understand genetic causes of complex disease traits. At present, identifying gene-gene interactions from genome-wide case-control studies is computationally and methodologically challenging.
arxiv
Ecology Letters, 2012 Although crucial for the understanding of adaptive evolution, genetically resolved examples of local adaptation are rare. To maximize survival and reproduction in their local environment, hosts should resist their local parasites and pathogens. The major
C. Eizaguirre +3 more
semanticscholar +1 more source
Transcriptome Landscape of Cancer‐Associated Fibroblasts in Human PDAC
Advanced Science, EarlyView.AP‐1 family members FOS and JUN regulate the malignant phenotype conversion of normal fibroblasts (NFs) to normal‐like cancer‐associated fibroblasts (nCAFs), while transforming growth factor‐β (TGFβ) and interferon‐γ (IFNγ) signals triggers the interconversion between classic myofibroblastic CAFs (myCAFs) and inflammatory CAFs (iCAFs), respectively ...
Mengyu Tao +15 more
wiley +1 more source
MicroRNA binding site variation is enriched in psychiatric disorders
Human Mutation, Volume 43, Issue 12, Page 2153-2169, December 2022., 2022 Abstract Psychiatric disorders have a polygenic architecture, often associated with dozens or hundreds of independent genomic loci. Most associated loci impact noncoding regions of the genome, suggesting that the majority of disease heritability originates from the disruption of regulatory sequences.
Michael P. Geaghan +2 more
wiley +1 more source
Genomic Diversity of the Major Histocompatibility Complex in Health and Disease
Cells, 2019 The human Major Histocompatibility Complex (MHC) genes are part of the supra-locus on chromosome 6p21 known as the human leukocyte antigen (HLA) system [...]
Jerzy K. Kulski +2 more
doaj +1 more source
The Major Histocompatibility Complex in Bovines: A Review
ISRN Veterinary Science, 2012 Productivity in dairy cattle and buffaloes depends on the genetic factors governing the production of milk and milk constituents as well as genetic factors controlling disease resistance or susceptibility. The immune system is the adaptive defense system
J. Behl +5 more
semanticscholar +1 more source