Results 141 to 150 of about 242,210 (352)

Orchestration of Skin Pathology in Cutaneous Lupus Erythematosus by HLA Class I Down‐Regulated Senescent Epidermal Basal Cells

Arthritis &Rheumatology, EarlyView.
Objective This study investigates the role of senescent epidermal basal cells in cutaneous lupus erythematosus (CLE) pathogenesis using skin samples from patients with CLE and a mouse model of systemic lupus erythematosus (SLE). Methods Cellular senescence profiling used datasets from the NCBI GEO database and Accelerating Medicines Partnership (AMP ...
Sena Yamamoto, Yuki Saito, Tsukasa Sato, Seina Nakano, Dain Kasseki, Ayaka Nagao, Norihiro Miura, Kentaro Nagaoka, Arisa Kita, Maki Miyajima, Shogo Ijima, Koji Taniguchi, Atsushi Niida, Takako S. Chikenji   +13 more
wiley   +1 more source

The Tyrosine Binding Pocket in the Adaptor Protein 1 (AP-1) μ1 Subunit Is Necessary for Nef to Recruit AP-1 to the Major Histocompatibility Complex Class I Cytoplasmic Tail [PDF]

, 2007
Elizabeth R. Wonderlich, Maya Williams, Kathleen L. Collins   +2 more
openalex   +1 more source

Antiphospholipid Syndrome: An Antibody‐Mediated Disease With Emerging Therapeutic Opportunities

Arthritis &Rheumatology, EarlyView.
Antiphospholipid syndrome (APS) is an autoimmune thromboinflammatory disease characterized by vascular thrombosis, pregnancy morbidity, and other manifestations driven by antiphospholipid autoantibodies. In this review, we present a clinical case that illustrates some diagnostic and therapeutic challenges in managing severe, relapsing APS ...
Thalia G. Newman, Jason S. Knight
wiley   +1 more source

Versatility of using major histocompatibility complex class II dextramers for derivation and characterization of antigen-specific, autoreactive T cell hybridomas

, 2015
Bharathi Krishnan, Chandirasegaran Massilamany, Rakesh H. Basavalingappa, Rajkumar Arumugam, Charles Kuszynski, Barbara L. Switzer, Daniel A. Peterson, Jay Reddy   +7 more
openalex   +1 more source

Extended major histocompatibility complex haplotypes in type I diabetes mellitus. [PDF]

, 1984
D Raum, Z Awdeh, E.J. Yunis, C A Alper, Kenneth H. Gabbay   +4 more
openalex   +1 more source

Linking Skin and Joint Inflammation in Psoriatic Arthritis through Shared CD8+ T Cell Clones

Arthritis &Rheumatology, EarlyView.
Objective Psoriatic arthritis (PsA) is an HLA class I–associated inflammatory arthritis that develops in up to 30% of people with psoriasis. We tested the hypothesis that skin and joint inflammation in PsA is linked in terms of CD8+ T cell phenotype and clonality.
Lucy E. Durham, Frances Humby, Nora Ng, Roman Laddach, Elizabeth H. Gray, Sarah E. Ryan, Kathryn J. A. Steel, Rosie Ross, Giovanni A. M. Povoleri, Rosamond Nuamah, Kathy Fung, Athul Menon Kallayil, Pawan Dhami, Bruce W. Kirkham, Leonie S. Taams   +14 more
wiley   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

A Tolerogenic Plasmid Inhibits Autoantibody Production Triggered by Immunization With Human Peptidyl Arginine Deiminase 4

Arthritis &Rheumatology, EarlyView.
Objective Rheumatoid arthritis (RA) is usually preceded and likely mediated by autoantibodies to citrullinated proteins (ACPAs) that recognize citrulline residues on multiple proteins. Conversion of arginine into citrulline is performed by enzymes called peptidyl arginine deiminases (PADs). We have previously demonstrated that the human PAD4 (hPAD4) is
Philippe P. Pagni, Vijetha Kumar, Nathalie C. Lambert, Eva Frison, Herve Luche, Marielle Mello, Magali Torres, Johnna D. Wesley, Matthias von Herrath, Jean Roudier, Isabelle Auger   +10 more
wiley   +1 more source

Comparative Effectiveness of Abatacept Versus Adalimumab in Shared Epitope Positive and Negative Patients With Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective The effect of the shared epitope (SE) and valine at position 11 (Val11) of HLA–DRB1 on the activation of CD4+ T cells is expected to be diminished by abatacept, a costimulation blocker. However, published evidence on the value of genetic stratification for abatacept treatment is conflicting. We aimed to compare the difference in effectiveness
Chuan Fu Yap, Nisha Nair, Seema D. Sharma, John Bowes, Amirah Binti Mohammad Ariff, Ann W. Morgan, John D. Isaacs, Anthony G. Wilson, Kimme L. Hyrich, Suzan Verstappen, James Bluett, Andrew P. Morris, Anne Barton, Darren Plant, Sebastien Viatte   +14 more
wiley   +1 more source

Major histocompatibility complex class II invariant chain expression in non‐antigen‐presenting cells

, 2001
Hanne Veenstra, William Frank Ferris, Patrick Bouic   +2 more
openalex   +1 more source