Results 141 to 150 of about 235,574 (356)

Insights into the Mechanisms of Immune‐Checkpoint Inhibitors Gained from Spatiotemporal Dynamics of the Tumor Microenvironment

open access: yesAdvanced Science, EarlyView.
This review summarizes recent advances in the spatiotemporal dynamics of the tumor microenvironment (TME). It highlights the roles of diverse immune and stromal cell populations, spatial architecture of the TME, as well as the gut and tumor microbiota in influencing responses to immune checkpoint inhibitors (ICIs), by integrating insights from single ...
Yuanyuan Zhang, Zhihua Liu
wiley   +1 more source

Expression of natural killer receptor alleles at different Ly49 loci occurs independently and is regulated by major histocompatibility complex class I molecules. [PDF]

open access: yes, 2001
Ly49 receptor genes are expressed by subsets of natural killer (NK) cells in an overlapping fashion, accounting for the capacity of NK subsets to attack host cells that have selectively downregulated self-major histocompatibility complex (MHC) class I ...
Hanke, T   +4 more
core   +1 more source

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang   +15 more
wiley   +1 more source

Differential detection of impact site versus rotational site injury by magnetic resonance imaging and microglial morphology in an unrestrained mild closed head injury model. [PDF]

open access: yes, 2016
Seventy-five percent of all traumatic brain injuries are mild and do not cause readily visible abnormalities on routine medical imaging making it difficult to predict which individuals will develop unwanted clinical sequelae. Microglia are brain-resident
Carson, Monica J   +4 more
core  

Modulation of Aging Diseases via RAGE Targets: A Dietary Intervention Review

open access: yesAdvanced Science, EarlyView.
This paper analyzes RAGE ligand‐binding mechanisms and signaling, proposing intervention strategies targeting these interactions. It emphasizes dietary polyphenols, polysaccharides, and terpenoids delivered via functional foods for anti‐aging. These compounds offer long‐term, safe intervention through dietary supplementation, providing dual nutritional
Qian Wu   +7 more
wiley   +1 more source

Control of mating preferences in mice by genes in the major histocompatibility complex.

open access: bronze, 1976
K Yamazaki   +8 more
openalex   +1 more source

Mechanically Active Hydrogel for Healing Intestinal Fistulas through the YAP‐Mediated Mechanosensitization of Intestinal Epithelial Cells

open access: yesAdvanced Science, EarlyView.
This study develops the hydrogel with antimicrobial, adhesive, degradable, injectable, and temperature‐sensitive contraction properties based on the transcriptomic and pathological characteristics of intestinal fistula patients. This hydrogel can seal rabbit intestinal fistula in situ, reduce the intestinal defect, and promote intestinal epithelial ...
Ze Li   +12 more
wiley   +1 more source

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