Alimentary Pharmacology &Therapeutics, EarlyView.Individualized assessment identifies patients with decompensated autoimmune hepatitis cirrhosis who are likely to benefit from a time‐limited trial of immunosuppression versus those requiring immediate liver transplant evaluation. Early objective response monitoring (bilirubin, MELD‐Na and AST/ALT) guides continuation of immunosuppression, promotes ...
Pedro Robson Costa Passos +2 more
wiley +1 more source
NGSMHC: a simple bioinformatics tool for comprehensively typing major histocompatibility complex genes in non-human species using next-generation sequencing data. [PDF]
Anim BiosciKang M +5 more
europepmc +1 more source
British Journal of Haematology, EarlyView.Summary Gastrointestinal acute graft‐versus‐host disease (GI aGVHD) remains a major complication after allogeneic haematopoietic stem cell transplantation (allo‐HSCT), and early risk identification and intervention are essential for improving outcomes.
Gao Mengge +8 more
wiley +1 more source
Patient-Derived Neurons Exhibit α-Synuclein Pathology and Previously Unrecognized Major Histocompatibility Complex Class I Elevation in Mitochondrial Membrane Protein-Associated Neurodegeneration. [PDF]
Mov DisordHeger LM +18 more
europepmc +1 more source
From haemostasis to immunity: The expanding frontiers of platelet biology
British Journal of Haematology, EarlyView.Platelets are versatile cells whose functions extend far beyond haemostasis and thrombosis, actively regulating innate and adaptive immunity, angiogenesis, lymphangiogenesis, liver regeneration, atherosclerosis and tumour metastasis. This demonstrates their central role in various physiological processes and multiple life‐threatening diseases ...
Xun Grace Wu, Nicole Tomei, Heyu Ni
wiley +1 more source
Four Target Resequencing for the Bovine Major Histocompatibility Complex Region. Proof of Concept. [PDF]
HLAGiovambattista G +7 more
europepmc +1 more source
Single-cell and spatial transcriptomic analysis reveal cellular heterogeneity and cancer cell-intrinsic major histocompatibility complex II expression in urothelial carcinoma. [PDF]
Int J Biol SciXiong S +13 more
europepmc +1 more source
Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges
British Journal of Pharmacology, EarlyView.This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu +6 more
wiley +1 more source
The Role of the Major Histocompatibility Complex Region on Chromosome 6 in Skin Atrophy: A Mendelian Randomization Study. [PDF]
J Cosmet DermatolZhao C, Fan Z, Zhang R, Sun Y, Li WY.
europepmc +1 more source
Targeting KRAS for cancer therapy
British Journal of Pharmacology, EarlyView.In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia +4 more
wiley +1 more source