Results 151 to 160 of about 680,011 (354)

Phosphatase inhibitors block in vivo binding of peptides to class I major histocompatibility complex molecules.

, 1994
Matthew Tector, Q Zhang, Russell D. Salter   +2 more
openalex   +1 more source

Trans-acting element(s) operating across species barriers positively regulate expression of major histocompatibility complex class II genes. [PDF]

, 1985
Roberto S. Accolla, Léonardo Scarpellino, Giovanna Carrà, John Guardiola   +3 more
openalex   +1 more source

BHLHE40 Orchestrates Effector Tissue‐Resident Memory CD8+ T Cells and Limits Long‐Term Survival of Kidney Graft

Advanced Science, EarlyView.
An effector subset of TRM, defined as CD49a+PD1hi CD8+ TRM, represents a BHLHE40‐orchestrated resident immune component that, rather than circulating cells, plays as a major contributor to allograft rejection. ABSTRACT Tissue‐resident memory T cells (TRM), which function against tumors, infections, and non‐self antigens in organ transplantation ...
Junbo Li, Bo Yang, Tianhui Pan, Xi Zhou, Zhibo Ma, Du Tang, Bowen Xie, Jing Liu, Zhishui Chen, Peixiang Lan   +9 more
wiley   +1 more source

Referee report. For: A step-by-step overview of the dynamic process of epitope selection by major histocompatibility complex class II for presentation to helper T cells [version 1; referees: 4 approved]

, 2016
Nilabh Shastri
openalex   +1 more source

A Subset of Pro‐inflammatory CXCL10+ LILRB2+ Macrophages Derives From Recipient Monocytes and Drives Renal Allograft Rejection

Advanced Science, EarlyView.
This study uncovers a recipient‐derived monocyte‐to‐macrophage trajectory that drives inflammation during kidney transplant rejection. Using over 150 000 single‐cell profiles and more than 850 biopsies, the authors identify CXCL10+ macrophages as key predictors of graft loss.
Alexis Varin, Jovanne Palvair, Lennie Messager, Jamal Bamoulid, Jasper Callemeyn, Mélanie Chaintreuil, Ludivine Dal Zuffo, Didier Ducloux, Imane Farhat, Mathieu Legendre, Laurent Martin, Florian Renosi, Xavier Roussel, Thibaut Vaulet, Maarten Naesens, Claire Tinel, Baptiste Lamarthée   +16 more
wiley   +1 more source

Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue').

Gastroenterology, 1992
M. Marsh
semanticscholar   +1 more source

ADAM metallopeptidase domain 17 (ADAM17) is naturally processed through major histocompatibility complex (MHC) class I molecules and is a potential immunotherapeutic target in breast, ovarian and prostate cancers

, 2010
Gomathinayagam Sinnathamby, Jennifer Zerfass, Julie Hafner, Peter D. Block, Zacharie Nickens, A. C. Hobeika, Angeles Alvarez Secord, H. Kim Lyerly, Michael A. Morse, Ramila Philip   +9 more
openalex   +2 more sources

Major Histocompatibility Complex Variation and Haplotype Associated Survival in Response to Experimental Infection of Two Bd-GPL Strains Along a Latitudinal Gradient [PDF]

, 2022
Maria Cortázar‐Chinarro, Sara Meurling, Laurens Schroyens, Mattias Siljestam, Àlex Richter‐Boix, Anssi Laurila, ‎Jacob Höglund   +6 more
openalex   +1 more source

TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2

Advanced Science, EarlyView.
This study identifies the E3 ligase TRIM40 as a key driver of pathological cardiac hypertrophy. TRIM40 binds PKN2 via its B‐box domain and, through its C29‐dependent catalytic activity, mediates K63‐linked ubiquitination of PKN2. This modification enhances PKN2 phosphorylation at Ser815, thereby driving hypertrophy.
Risheng Zhao, Xiaoli Cui, Huizhu Du, Zhuoqun Wang, Chang Liu, Linxin Zhang, Jianing Qi, Di Yang, Hui Yu, Shuang Yan, Wei Liu, Haiming Sun, Mengyang Wang   +12 more
wiley   +1 more source

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source