Thymic T cells are driven to expand upon interaction with self-class II major histocompatibility complex gene products on accessory cells. [PDF]
Kenneth L. Rock, Beryl R. Benacerraf
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Genes of the Major Histocompatibility Complex
L, Hood +17 more
openaire +2 more sources
Objective Osteoarthritis (OA) is a debilitating joint disease that is characterized by cartilage degradation, synovial inflammation, and pain. Macrophages have been implicated in OA pathology, but the origins and functions of diverse macrophage subsets seeding the synovial joint tissue remain incompletely understood.
Damien Laouteouet +18 more
wiley +1 more source
MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I-ASSOCIATED VACCINE PROTECTION FROM SIMIAN IMMUNODEFICIENCY VIRUS-INFECTED PERIPHERAL-BLOOD CELLS [PDF]
Boes, J +14 more
core +1 more source
Objective Polymyalgia rheumatica (PMR) is an age‐related inflammatory disease with shoulder/hip girdle involvement. Magnetic resonance imaging (MRI) reveals extracapsular/entheseal soft tissue involvement in both PMR and spondyloarthritis (SpA), with sacroiliac joint and perientheseal spinal bone marrow edema (BME) being characteristic of SpA ...
Kerem Abacar +12 more
wiley +1 more source
The protease inhibitor, N-acetyl-L-leucyl-L-leucyl-leucyl-L-norleucinal, decreases the pool of major histocompatibility complex class I-binding peptides and inhibits peptide trimming in the endoplasmic reticulum. [PDF]
Eric Hughes +3 more
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Case‐Based Immunology: B Cells and Systemic Sclerosis Interstitial Lung Disease
Interstitial lung disease (ILD) is an important complication of systemic sclerosis (SSc), with high mortality and morbidity. Recent clinical studies in SSc‐ILD have led to US Food and Drug Administration–approved therapies in SSc‐ILD. Importantly, evidence from these studies has been extrapolated to guide management of ILDs of other systemic autoimmune
Nina Goldman +2 more
wiley +1 more source
Association of the Invariant Chain with Major Histocompatibility Complex Class I Molecules Directs Trafficking to Endocytic Compartments [PDF]
Masahiko Sugita, Michael B. Brenner
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