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The major histocompatibility complex origin
Immunological Reviews, 2004Summary: The present review focuses on the history of genes involved in the major histocompatibility complex (MHC), with a special emphasis on class I function in peptide presentation. The MHC class II story is covered in less detail, as it does not have a major impact on the general understanding of the MHC evolution. We first redefine the MHC as the
Danchin, Etienne +6 more
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New major histocompatibility complex genes
Human Immunology, 1993The MHC is a region of some 4 megabases that has been studied intensively owing to the large number of diseases that are associated with susceptibility genes within this region of the genome. The total number of genes located within the MHC is now approximately 100, but more can be predicted.
B, Marshall +5 more
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International Journal of Immunogenetics, 1990
SUMMARYThe rabbit MHC class II DP, DQ, and DR alpha and beta chain genes were transfected into murine B lymphoma cells. The transfected cells expressed R‐DQ and R‐DR molecules on the cell surface but they did not express the R‐DP genes either on the cell surface or at the level of mRNA.
H, Spieker-Polet +3 more
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SUMMARYThe rabbit MHC class II DP, DQ, and DR alpha and beta chain genes were transfected into murine B lymphoma cells. The transfected cells expressed R‐DQ and R‐DR molecules on the cell surface but they did not express the R‐DP genes either on the cell surface or at the level of mRNA.
H, Spieker-Polet +3 more
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Major histocompatibility complex, t-complex, and leukemia
Cancer Causes and Control, 1992In experimental models, leukemia was the first disease shown to have an association with the major histocompatibility complex (MHC) genes. In humans, several allelic human-leukocyte antigen (HLA) associations also have been recognized. In addition to allelic associations, atypical HLA segregation patterns have been observed in leukemic families.
M T, Dorak, A K, Burnett
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Major Histocompatibility Complex
1999The first recognition of MHC genes was based on their ability to encode proteins that serve as identity markers on tissues and cells that have been transplanted into an incompatible recipient. Their recognition by the recipient’s lymphocytes leads to prompt rejection.
Julius M. Cruse, Robert E. Lewis
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The Major Histocompatibility Complex
1986At the beginning of this century, Tyzzer and Loeb showed that tumors of a strain of mice (A/A) grow normally if they are transplanted into mice of the same inbred strain (syngeneic, see Table 6.1); however, they are rejected by mice of another inbred strain (allogeneic, e.g., B/B).
Dietrich Götze, Reinhard Burger
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