Results 51 to 60 of about 680,011 (354)

Growth of donor-derived dendritic cells from the bone marrow of murine liver auograft recipients in response to granulocyte/macrophage colony-stimulating factor [PDF]

, 1995
Allografts of the liver, which has a comparatively heavy leukocyte content compared with other vascularized organs, are accepted permanently across major histocompatibility complex barriers in many murine strain combinations without immunosuppressive ...
Fu, F, Fung, JJ, Lu, L, McCaslin, D, Qian, S, Rao, AS, Rudert, WA, Starzl, TE, Thomson, AW, Trucco, M   +9 more
core   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Major histocompatibility complex B variability in Korean native chicken breeds

Poultry Science, 2020
Adaptive genetic variations have direct influences on the fitness traits of the animal. The major histocompatibility complex B (MHC-B) region is responsible for adaptive and innate immune responses in chickens.
Prabuddha Manjula, Janet E. Fulton, Dongwon Seo, Jun Heon Lee   +3 more
doaj   +1 more source

Comparative Genomics of the Major Histocompatibility Complex (MHC) of Felids

Frontiers in Genetics, 2022
This review summarizes the current knowledge on the major histocompatibility complex (MHC) of the family Felidae. This family comprises an important domestic species, the cat, as well as a variety of free-living felids, including several endangered ...
Martin Plasil, Martin Plasil, Jan Futas, Jan Futas, April Jelinek, Pamela A. Burger, Petr Horin, Petr Horin   +7 more
doaj   +1 more source

Major Histocompatibility Complex and Cell Cooperation [PDF]

, 2017
We have studied the role of major histocompatibility antigens on cell cooperation in the immune response of the chicken. In the 1970's, shortly after the initial discoveries in the mouse, we demonstrated that the T cell-B cell interaction is major ...
TOIVANEN, AULI, TOIVANEN, PAAVO, VAINIO, OLLI   +2 more
core  

Systemic T Cell Receptor Profiling Reveals Adaptive Immune Activation and Potential Immune Signatures of Diagnosis and Brain Atrophy in Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy is increasingly associated with immune dysregulation and inflammation. The T cell receptor (TCR), a key mediator of adaptive immunity, shows repertoire alterations in various immune‐mediated diseases. The unique TCR sequence serves as a molecular barcode for T cells, and clonal expansion accompanied by reduced overall TCR ...
Yong‐Won Shin, Sang Bin Hong, Yong Woo Shin, Inpyeong Hwang, Jaeseong Oh, Jihyeon Choi, Narae Kim, Jangsup Moon, Keun‐Hwa Jung, Kyung‐Il Park, Ki‐Young Jung, Kon Chu, Sang Kun Lee   +12 more
wiley   +1 more source

The major histocompatibility complex participates in Parkinson’s disease

Pharmacological Research
Parkinson’s disease (PD) is a common neurodegenerative disease characterized by progressive loss of dopaminergic neurons in the substantia nigra and the aggregation of alpha-synuclein (α-syn).
Rou Gu, Jianyu Pan, Maher Un Nisa Awan, Xiaowei Sun, Fang Yan, Liping Bai, Jie Bai   +6 more
doaj   +1 more source

Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1

Nature Communications, 2015
Ankylosing spondylitis (AS) is a common, highly heritable, inflammatory arthritis for which HLA-B*27 is the major genetic risk factor, although its role in the aetiology of AS remains elusive.
A. Cortes, S. Pulit, P. Leo, J. J. Pointon, P. Robinson, M. Weisman, Michael D. Ward, L. Gensler, Xiaodong Zhou, H. Garchon, G. Chiocchia, J. Nossent, B. Lie, Ø. Førre, J. Tuomilehto, K. Laiho, L. Bradbury, D. Elewaut, R. Burgos-Vargas, S. Stebbings, L. Appleton, C. Farrah, Jonathan Lau, N. Haroon, J. Mulero, F. Blanco, M. González-Gay, C. López-Larrea, P. Bowness, K. Gaffney, H. Gaston, D. Gladman, P. Rahman, W. Maksymowych, J. Crusius, I. E. van der Horst-Bruinsma, R. Valle-Oñate, C. Romero-sanchez, I. M. Hansen, F. Pimentel-Santos, R. Inman, Javier Martín, M. Breban, Bryan Paul Wordsworth, J. Reveille, David M. Evans, P. D. de Bakker, M. Brown   +47 more
semanticscholar   +1 more source

Olink Proteomics Analysis Reveals Heterogeneous Responses to FcRn Blockade in Anti‐AChR Antibody‐Positive Myasthenia Gravis: FGF‐19 as a Novel Biomarker

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to systematically observe the clinical manifestations, immune cell subsets, and dynamic changes in serological indicators in patients with myasthenia gravis (MG) before and after efgartigimod (EFG) treatment. Methods We analyzed the baseline data, laboratory parameters, and lymphocyte subset proportions in MG ...
Tiancheng Luo, Deyou Peng, Zhouao Zhang, Mingjin Yang, Xinyan Guo, Tianyu Ma, Xiaoyu Huang, Mingming Xu, Linlin Fu, Yong Zhang   +9 more
wiley   +1 more source

The Association of Myasthenia Gravis with HLA class II Antigens in Iraqi Patients

مجلة بغداد للعلوم, 2013
The nature and intensity of the association of myasthenia gravis (MG) with distinct human leukocyte antigen (HLA) haplotypes differ between ethnic populations, so this study determined the association of HLA class II antigens with myasthenia gravis (MG ...
Baghdad Science Journal
doaj   +1 more source