Results 41 to 50 of about 9,502,784 (300)

The major histocompatibility complex participates in Parkinson’s disease

Pharmacological Research
Parkinson’s disease (PD) is a common neurodegenerative disease characterized by progressive loss of dopaminergic neurons in the substantia nigra and the aggregation of alpha-synuclein (α-syn).
Rou Gu, Jianyu Pan, Maher Un Nisa Awan, Xiaowei Sun, Fang Yan, Liping Bai, Jie Bai   +6 more
doaj   +1 more source

Major histocompatibility complex and its importance towards controlling infection

Asian Journal of Medical Sciences, 2017
It is well documented that infectious pathogen burden and infected cell mass determine the clinical severity of infectious diseases, however, the ability of the host to recognize and process antigens to produce antibodies or the cellular immune response ...
Langamba Angom Longjam
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Isolation and characterization of MHCIIA gene from Nile tilapi a [PDF]

Delta Journal of Science, 2019
This study was conducted to isolate and characterize the majorhistocompatibility complex (MHC) class IIA gene from Nile tilapiaand to compare between different genotypes of this gene followinginfection with Aeromonas hydrophila.
Tarek M. Mohamed, Mohammed A. El-Magd, Karim S. El-Said, Aml A. El-Semlawy   +3 more
doaj   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Interferon y Stimulation Modulates the Proteolytic Activity and Cleavage Site Preference of 20S Mouse Proteasomes [PDF]

, 1994
The proteasome is a 700-kD multisubunit enzyme complex with several proteolytically active sites. The enzyme complex is involved in both ubiquitin-dependent and -independent protein degradation and may contribute to the processing of antigens presented ...
Multhaupt, Gerd, Koszinowski, Ulrich H., Kloetzel, Peter-M., Boes, Bettina, Ruppert, Thomas, Hengel, Hartmut   +5 more
core   +1 more source

Infectious Diseases and Immunity: Special Reference to Major Histocompatibility Complex

Emerging Infectious Diseases, 1997
Human leukocyte antigens (HLAs) are an inherent system of alloantigens, which are the products of genes of the major histocompatibility complex (MHC).
Neeloo Singh, S. Agrawal, A.K. Rastogi
doaj   +1 more source

Major histocompatibility complex class IIB disassortative mate choice in a genetically monogamous seabird. [PDF]

Proc Biol Sci
International audienceAmong species reproducing sexually, mating strategies represent a major component of individual fitness. The major histocompatibility complex (MHC) is an extremely diverse set of genes responsible for immunological recognition and ...
Thel L, Pineaux M, Ribeiro L, Danchin E, Whelan S, Hatch SA, Blanchard P, Leclaire S.   +7 more
europepmc   +2 more sources

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Vaccination with Recombinant Cryptococcus Proteins in Glucan Particles Protects Mice against Cryptococcosis in a Manner Dependent upon Mouse Strain and Cryptococcal Species

mBio, 2017
Development of a vaccine to protect against cryptococcosis is a priority given the enormous global burden of disease in at-risk individuals. Using glucan particles (GPs) as a delivery system, we previously demonstrated that mice vaccinated with crude ...
Charles A. Specht, Chrono K. Lee, Haibin Huang, Maureen M. Hester, Jianhua Liu, Bridget A. Luckie, Melanie A. Torres Santana, Zeynep Mirza, Payam Khoshkenar, Ambily Abraham, Zu T. Shen, Jennifer K. Lodge, Ali Akalin, Jane Homan, Gary R. Ostroff, Stuart M. Levitz   +15 more
doaj   +1 more source