Results 21 to 30 of about 9,502,784 (300)

Distinct Intracellular Compartments Involved in Invariant Chain Degradation and Antigenic Peptide Loading of Major Histocompatibility Complex (MHC) Class II Molecules [PDF]

, 1997
Major histocompatibility complex (MHC) class II molecules are transported to intracellular MHC class II compartments via a transient association with the invariant chain (Ii).
Pieters, J., Watts, Colin, Knight, Andrew M., Colin Watts, Ferrari, Giorgio, Andrew M. Knight, Pieters, Jean, Ferrari, G., Watts, C., Jean Pieters, Giorgio Ferrari, Knight, A. M.   +11 more
core   +1 more source

Major Histocompatibility Complex–Matched Arteries Have Similar Patency to Autologous Arteries in a Mauritian Cynomolgus Macaque Major Histocompatibility Complex–Defined Transplant Model

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Arterial bypass and interposition grafts are used routinely across multiple surgical subspecialties. Current options include both autologous and synthetic materials; however, each graft presents specific limitations.
John P. Maufort, Jacqueline S. Israel, Matthew E. Brown, Steve J. Kempton, Nicholas J. Albano, Weifeng Zeng, Laurel E. Kelnhofer, Matthew R. Reynolds, Elizabeth S. Perrin, Ruston J. Sanchez, Igor I. Slukvin, James A. Thomson, Samuel O. Poore   +12 more
doaj   +3 more sources

A Physical Map Including a New Class I Gene (cda12) of the Human Major Histocompatibility Complex (A2/313 Haplotype) Derived from a Monosomy 6 Mutant Cell Line [PDF]

, 1989
To avoid interpretative problems due to restriction fragment length polymorphisms, the monosomy 6 mutant cell line BM19.7 was employed to establish a molecular map of the human major histocompatibility (HLA) complex in the A2,B13,Bw4,DRw6,DRw52,DQw1,DPw2
Pohla, Heike, Bloemer, K, Messer, Gerald, Bloemer, Katharina, Messer, G, Ziegler, Andreas, Ragoussis, Jiannis, Ragoussis, J, Weiss, Elisabeth H., Pohla, H, Weiss, EH, Ziegler, A   +11 more
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Evidence for directional selection at a novel major histocompatibility class I marker in wild common frogs (Rana temporaria) exposed to a viral pathogen (Ranavirus). [PDF]

, 2009
(c) 2009 Teacher et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Trenton W J Garner, Richard A. Nichols, Trenton W. J. Garner, Garner, TWJ, Teacher, AGF, Amber G F Teacher, Teacher Amber G. F., Richard A Nichols, Garner Trenton W. J., Amber G. F. Teacher, Nichols, RA, Nichols Richard A.   +11 more
core   +1 more source

Production of Triple-Gene (GGTA1, B2M and CIITA)-Modified Donor Pigs for Xenotransplantation

Frontiers in Veterinary Science, 2022
Activation of human immune T-cells by swine leukocyte antigens class I (SLA-I) and class II (SLA-II) leads to xenograft destruction. Here, we generated the GGTA1, B2M, and CIITA (GBC) triple-gene-modified Diannan miniature pigs, analyzed the ...
Kaixiang Xu, Kaixiang Xu, Kaixiang Xu, Honghao Yu, Shuhan Chen, Shuhan Chen, Shuhan Chen, Yaxuan Zhang, Yaxuan Zhang, Yaxuan Zhang, Jianxiong Guo, Jianxiong Guo, Chang Yang, Chang Yang, Deling Jiao, Deling Jiao, Deling Jiao, Tien Dat Nguyen, Tien Dat Nguyen, Tien Dat Nguyen, Heng Zhao, Heng Zhao, Heng Zhao, Jiaoxiang Wang, Jiaoxiang Wang, Jiaoxiang Wang, Taiyun Wei, Taiyun Wei, Honghui Li, Honghui Li, Honghui Li, Baoyu Jia, Baoyu Jia, Baoyu Jia, Muhammad Ameen Jamal, Muhammad Ameen Jamal, Muhammad Ameen Jamal, Hong-Ye Zhao, Hong-Ye Zhao, Xingxu Huang, Hong-Jiang Wei, Hong-Jiang Wei, Hong-Jiang Wei, Hong-Jiang Wei   +43 more
doaj   +1 more source

Endogenous versus exogenous fatty acid availability affects lysosomal acidity and MHC class II expression

Journal of Lipid Research, 2006
Although the immune system, inflammation, and cellular metabolism are linked to diseases associated with dyslipidemias, the mechanism(s) remain unclear.
S.C. Schweitzer, A.M. Reding, H.M. Patton, T.P. Sullivan, C.E. Stubbs, E. Villalobos-Menuey, S.A. Huber, M.K. Newell   +7 more
doaj   +1 more source

Immunological basis of differences in disease resistance in the chicken [PDF]

, 2002
Genetic resistance to diseases is a multigenic trait governed mainly by the immune system and its interactions with many physiologic and environmental factors.
Rebel, J.M.J., Zekarias, B., Huurne, A.A.H.M., ter, Landman, W.J.M., Gruys, E., Pol, J.M.A.   +5 more
core   +1 more source

Major histocompatibility complex genomic investigation of endangered Chinese alligator provides insights into the evolution of tetrapod major histocompatibility complex and survival of critically bottlenecked species

Frontiers in Ecology and Evolution, 2022
BackgroundThe major histocompatibility complex (MHC) gene family, a vital immune gene family in vertebrates, helps animals defend against pathogens. The polymorphism of MHC genes is important for a species and is considered to be caused by the numerous ...
Ke He, Ke He, Ying Zhu, Ying Zhu, Shang-Chen Yang, Qing Ye, Qing Ye, Sheng-Guo Fang, Qiu-Hong Wan   +8 more
doaj   +1 more source

Immunological studies of chronic ocular toxoplasmosis : up-regulation of major histocompatibility complex class I and transforming growth factor beta and a protective role for interleukin-6 [PDF]

, 2001
A murine model was used to characterize the local immune and inflammatory response during ocular toxoplasmosis. Major histocompatibility complex (MHC) class I, normally expressed at low levels in immune-privileged sites such as the eye, was up-regulated ...
Byrne, N., Anthony, J.P., Lyons, R., Roberts, F., Ferguson, D.J.P., Roberts, C.W., Alexander, J.   +6 more
core   +4 more sources

Evolution of major histocompatibility complex gene copy number.

PLoS Computational Biology, 2019
MHC genes, which code for proteins responsible for presenting pathogen-derived antigens to the host immune system, show remarkable copy-number variation both between and within species.
Piotr Bentkowski, Jacek Radwan
doaj   +1 more source