Results 21 to 30 of about 133,059 (255)

Major histocompatibility complex genomic investigation of endangered Chinese alligator provides insights into the evolution of tetrapod major histocompatibility complex and survival of critically bottlenecked species

Frontiers in Ecology and Evolution, 2022
BackgroundThe major histocompatibility complex (MHC) gene family, a vital immune gene family in vertebrates, helps animals defend against pathogens. The polymorphism of MHC genes is important for a species and is considered to be caused by the numerous ...
Ke He, Ke He, Ying Zhu, Ying Zhu, Shang-Chen Yang, Qing Ye, Qing Ye, Sheng-Guo Fang, Qiu-Hong Wan   +8 more
doaj   +1 more source

Skeletal muscle major histocompatibility complex class I and II expression differences in adult and juvenile dermatomyositis

Clinics, 2012
OBJECTIVE: To analyze major histocompatibility complex expression in the muscle fibers of juvenile and adult dermatomyositis. METHOD: In total, 28 untreated adult dermatomyositis patients, 28 juvenile dermatomyositis patients (Bohan and Peter's criteria)
Samuel Katsuyuki Shinjo, Adriana Maluf Elias Sallum, Clovis Artur Silva, Suely Kazue Nagahashi Marie   +3 more
doaj   +1 more source

The Marine Mammal Class II Major Histocompatibility Complex Organization

Frontiers in Immunology, 2019
Sirenians share with cetaceans and pinnipeds several convergent traits selected for the aquatic lifestyle. Living in water poses new challenges not only for locomotion and feeding but also for combating new pathogens, which may render the immune system ...
André Luiz Alves de Sá, André Luiz Alves de Sá, Breanna Breaux, Tibério Cesar Tortola Burlamaqui, Thaddeus Charles Deiss, Leonardo Sena, Michael Frederick Criscitiello, Maria Paula Cruz Schneider   +7 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Major histocompatibility complex: history of discovery, evolution, structure, significance in transplantation of allogeneic hematopoietic stem cells

Трансплантология (Москва), 2023
Aim. To reveal the significance of the major histocompatibility complex and the human leukocyte antigen evolutionary divergence in transplantation of allogeneic hematopoietic stem cells.
F. A. Omarova, M. Yu. Drokov, E. G. Khamaganova   +2 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The major histocompatibility complex participates in Parkinson’s disease

Pharmacological Research
Parkinson’s disease (PD) is a common neurodegenerative disease characterized by progressive loss of dopaminergic neurons in the substantia nigra and the aggregation of alpha-synuclein (α-syn).
Rou Gu, Jianyu Pan, Maher Un Nisa Awan, Xiaowei Sun, Fang Yan, Liping Bai, Jie Bai   +6 more
doaj   +1 more source

Major histocompatibility complex and its importance towards controlling infection

Asian Journal of Medical Sciences, 2017
It is well documented that infectious pathogen burden and infected cell mass determine the clinical severity of infectious diseases, however, the ability of the host to recognize and process antigens to produce antibodies or the cellular immune response ...
Langamba Angom Longjam
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Isolation and characterization of MHCIIA gene from Nile tilapi a [PDF]

Delta Journal of Science, 2019
This study was conducted to isolate and characterize the majorhistocompatibility complex (MHC) class IIA gene from Nile tilapiaand to compare between different genotypes of this gene followinginfection with Aeromonas hydrophila.
Tarek M. Mohamed, Mohammed A. El-Magd, Karim S. El-Said, Aml A. El-Semlawy   +3 more
doaj   +1 more source