Results 21 to 30 of about 102,809 (247)

Impact of Antigen Presentation Mechanisms on Immune Response in Autoimmune Hepatitis

Frontiers in Immunology, 2022
The liver is a very tolerogenic organ. It is continually exposed to a multitude of antigens and is able to promote an effective immune response against pathogens and simultaneously immune tolerance against self-antigens. In spite of strong peripheral and
Rossella Fasano, Rossella Fasano, Eleonora Malerba, Marcella Prete, Antonio Giovanni Solimando, Antonio Giovanni Solimando, Alessio Buonavoglia, Nicola Silvestris, Nicola Silvestris, Patrizia Leone, Vito Racanelli   +10 more
doaj   +1 more source

Production of Triple-Gene (GGTA1, B2M and CIITA)-Modified Donor Pigs for Xenotransplantation

Frontiers in Veterinary Science, 2022
Activation of human immune T-cells by swine leukocyte antigens class I (SLA-I) and class II (SLA-II) leads to xenograft destruction. Here, we generated the GGTA1, B2M, and CIITA (GBC) triple-gene-modified Diannan miniature pigs, analyzed the ...
Kaixiang Xu, Kaixiang Xu, Kaixiang Xu, Honghao Yu, Shuhan Chen, Shuhan Chen, Shuhan Chen, Yaxuan Zhang, Yaxuan Zhang, Yaxuan Zhang, Jianxiong Guo, Jianxiong Guo, Chang Yang, Chang Yang, Deling Jiao, Deling Jiao, Deling Jiao, Tien Dat Nguyen, Tien Dat Nguyen, Tien Dat Nguyen, Heng Zhao, Heng Zhao, Heng Zhao, Jiaoxiang Wang, Jiaoxiang Wang, Jiaoxiang Wang, Taiyun Wei, Taiyun Wei, Honghui Li, Honghui Li, Honghui Li, Baoyu Jia, Baoyu Jia, Baoyu Jia, Muhammad Ameen Jamal, Muhammad Ameen Jamal, Muhammad Ameen Jamal, Hong-Ye Zhao, Hong-Ye Zhao, Xingxu Huang, Hong-Jiang Wei, Hong-Jiang Wei, Hong-Jiang Wei, Hong-Jiang Wei   +43 more
doaj   +1 more source

Cryptic female choice favours sperm from major histocompatibility complex-dissimilar males [PDF]

, 2013
Cryptic female choice may enable polyandrous females to avoid inbreeding or bias offspring variability at key loci after mating. However, the role of these genetic benefits in cryptic female choice remains poorly understood. Female red junglefowl, Gallus
Alcaide M, Bakst MR, Burnham KP, Etches RJ, Janeway CA, Klein J, Olsson M, Parker GA, Trivers RL   +8 more
core   +1 more source

The major histocompatibility complex of reindeer

Rangifer, 1990
The major histocompatibility complex (MHC) is a system of closely linked genes showing an extremely high degree of polymorphism. These genes are major elements in the government of specific immune reactions.
I. Olsaker, K. H. Røed
doaj   +1 more source

Congruence as a measurement of extended haplotype structure across the genome

Journal of Translational Medicine, 2012
Background Historically, extended haplotypes have been defined using only a few data points, such as alleles for several HLA genes in the MHC. High-density SNP data, and the increasing affordability of whole genome SNP typing, creates the opportunity to ...
Baschal Erin E, Jasinski Jean M, Boyle Theresa A, Fain Pamela R, Eisenbarth George S, Siebert Janet C   +5 more
doaj   +1 more source

Determination of a predictive cleavage motif for eluted major histocompatibility complex class II ligands [PDF]

, 2018
CD4+ T cells have a major role in regulating immune responses. They are activated by recognition of peptides mostly generated from exogenous antigens through the major histocompatibility complex (MHC) class II pathway.
Dhanda, Sandeep Kumar, Edwards, Lindy, Jurtz, Vanessa, Karosiene, Edita, Nielsen, Morten, Paul, Sinu, Peters, Bjoern, Sette, Alessandro   +7 more
core   +6 more sources

Major Histocompatibility Complex–Matched Arteries Have Similar Patency to Autologous Arteries in a Mauritian Cynomolgus Macaque Major Histocompatibility Complex–Defined Transplant Model

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Arterial bypass and interposition grafts are used routinely across multiple surgical subspecialties. Current options include both autologous and synthetic materials; however, each graft presents specific limitations.
John P. Maufort, Jacqueline S. Israel, Matthew E. Brown, Steve J. Kempton, Nicholas J. Albano, Weifeng Zeng, Laurel E. Kelnhofer, Matthew R. Reynolds, Elizabeth S. Perrin, Ruston J. Sanchez, Igor I. Slukvin, James A. Thomson, Samuel O. Poore   +12 more
doaj   +3 more sources

Minors come of age: minor histocompatibility antigens and graft-versus-host disease [PDF]

, 2004
Minor histocompatibility antigens (miHA) are responsible for the occurrence of graft-versus-host disease in the setting of a major histocompatibility complex matched sibling allogeneic stem cell transplantation.
Chao, Nelson J
core   +1 more source

The Major Histocompatibility Complex in Transplantation

Journal of Transplantation, 2012
The transplant of organs is one of the greatest therapeutic achievements of the twentieth century. In organ transplantation, the adaptive immunity is considered the main response exerted to the transplanted tissue, since the principal target of the ...
Marco Antonio Ayala García, Beatriz González Yebra, Andrea Liliana López Flores, Eduardo Guaní Guerra   +3 more
doaj   +1 more source

Downregulation of major histocompatibility complex class I in bovine papillomas [PDF]

, 2004
Bovine papillomavirus (BPV) induces papillomas in cattle; in the great majority of cases, these regress due to the host immune response, but they can persist and progress to malignancy.
Araibi, E.H., Ashrafi, G.H., Campo, M.S., Marchetti, B.   +3 more
core   +1 more source