Results 71 to 80 of about 991,100 (420)
Recombinants of the major histocompatibility complex in the chicken [PDF]
, 1982 The primary purpose of this research was to produce and analyze recombinants of the major histocompatibility complex of the chicken in order to provide useful information concerning its structure and function.
Palmer, Douglas Keith
core +2 more sources
FEBS Letters, EarlyView.Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke +2 more
wiley +1 more source
MHC Class I+/II− Dendritic Cells Induce Hapten-Specific Immune Responses In Vitro and In Vivo [PDF]
, 1978 Activation requirements and biologic properties of hapten-specific, major histocompatibility complex class I-restricted CD8+ T lymphocytes are not fully understood.
Andrea Kolesaric +25 more
core +1 more source
Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells
Molecular Oncology, EarlyView.In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi +3 more
wiley +1 more source
Immunogenetics and infectious diseases: special reference to the mayor histocompatibility complex
Brazilian Journal of Infectious DiseasesMany studies have tried to identify genetic markers for infectious diseases, some of them have focused on human leukocyte antigens (HLA). The products of HLA genes interact with surface-specific receptors of T lymphocytes, resulting in activation of the ...
Crésio Alves +4 more
doaj +1 more source
Molecular Oncology, EarlyView.CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar +4 more
wiley +1 more source
Cholesterol lowering drug may influence cellular immune response by altering MHC II function[S]
Journal of Lipid Research, 2013 Major histocompatibility complex class II (MHC II) expressed on the surface of antigen-presenting cells (APCs) displays peptides to CD4+ T cells. Depletion of membrane cholesterol from APCs by methyl β-cyclodextrin treatment compromises peptide-MHC II ...
Koushik Roy +4 more
doaj
Contact map dependence of a T cell receptor binding repertoire [PDF]
arXiv, 2021 The T cell arm of the adaptive immune system provides the host protection against unknown pathogens by discriminating between host and foreign material. This discriminatory capability is achieved by the creation of a repertoire of cells each carrying a T cell receptor (TCR) specific to non-self antigens displayed as peptides bound to the major ...
arxiv
Major histocompatibility complex
, 2015 with molecular weight of about 45 kDa. This polypeptide folds into three separate domains called alpha -1, alpha -2 and alpha -3. β2 – microglobulin polypeptide is non – covalently associated with the alpha -3 domain.
Raja Rajalingam +3 more
semanticscholar +1 more source
PLoS Genetics, 2013 The major histocompatibility complex (MHC) region is strongly associated with multiple sclerosis (MS) susceptibility. HLA-DRB1*15:01 has the strongest effect, and several other alleles have been reported at different levels of validation.
N. Patsopoulos +16 more
semanticscholar +1 more source