Results 41 to 50 of about 2,057 (163)

Penetration of linezolid and tedizolid in cerebrospinal fluid of mouse and impact of blood–brain barrier disruption

Clinical and Translational Science, Volume 18, Issue 1, January 2025.
Abstract Penetration of antimicrobial treatments into the cerebrospinal fluid is essential to successfully treat infections of the central nervous system. This penetration is hindered by different barriers, including the blood–brain barrier, which is the most impermeable.
Marin Lahouati, Mélanie Oudart, Philippe Alzieu, Candice Chapouly, Antoine Petitcollin, Fabien Xuereb   +5 more
wiley   +1 more source

Etiologic Determinants and Characteristics of Diabetes in Haitian Youth (EDDHY Study)

Pediatric Diabetes, Volume 2025, Issue 1, 2025.
Aims: Published information on youth‐onset diabetes in Haiti is scarce, with limited data available on diabetes autoimmunity and genetic susceptibility to the disease. We determined the anthropometric, metabolic, and immunological characteristics and human leukocyte antigen (HLA)‐associated risks in patients with youth‐onset diabetes.
Eddy Jean-Baptiste, Philippe Larco, Julia E. Von Oettingen, Janelle A. Noble, Steven J. Mack, Ningyi Song, Harper R. N. Martin, Erik Rozemuller, Mark A. Atkinson, Denira Govender, Nancy Charles Larco, Graham D. Ogle, Andrea Scaramuzza   +12 more
wiley   +1 more source

Reduced Capacity of High‐Density Lipoprotein to Acquire Free Cholesterol From Triglyceride‐Rich Lipoproteins Is Associated With Elevated Postprandial Hypertriglyceridemia in Healthy Men

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The capacity of high‐density lipoprotein cholesterol (HDL) to acquire free cholesterol (FC) from triglyceride‐rich lipoproteins during lipoprotein lipase–dependent lipolysis in a process of reverse remnant cholesterol transport, has been ...
Sophie Galier, Maryam Darabi, Feng Ma, Clément Materne, Isabelle Guillas, Wilfried Le Goff, Anatol Kontush, Maryse Guerin   +7 more
doaj   +1 more source

Role of C5 inhibition in Idiopathic Inflammatory Myopathies and Scleroderma Renal Crisis–Induced Thrombotic Microangiopathies

Kidney International Reports, 2021
Introduction: Connective tissue diseases, including systemic sclerosis and idiopathic inflammatory myopathies (IIMs), are a very rare cause of thrombotic microangiopathies (TMAs). Whether dysregulation of the complement pathways underlies these secondary
Anna Gouin, David Ribes, Magali Colombat, Dominique Chauveau, Gregoire Prevot, Olivier Lairez, Gregory Pugnet, Veronique Fremeaux-Bacchi, Antoine Huart, Julie Belliere, Stanislas Faguer   +10 more
doaj   +1 more source

Strengthening health‐focused climate adaptation in Canada: Barriers and interventions

Canadian Geographer / Le géographe canadien, Volume 68, Issue 4, Page 445-450, Winter / hiver 2024.
Abstract Climate change poses a dire threat to human health. Within Canada, extreme heat events are contributing to cardiovascular disease, poor air quality is causing respiratory distress, and changing precipitation patterns are resulting in the spread of vector‐borne illness.
Desiree Rose, S. Jeff Birchall
wiley   +1 more source

Les Maladies Cardiovasculaires Chez les Patients en Hémodialyse Chronique à Bouaké

Health Research in Africa
RÉSUMÉ Introduction. L’hémodialyse chronique (HDC) occupe une place importante dans la prise en charge des patients en insuffisance rénale chronique terminale (IRCT), car elle prolonge la durée et améliore la qualité de vie.
Manzan E A Wognin, Hubert K Yao, Weu M Tia, Weu M Tia, Sébastienne A Yao, Christ Reine Marie Koffi, Monlet C Guei, Loa Ambroise Gnaba, Kehi J Kpan, Abdoul Y Gonan, Bourhaïma O   +10 more
doaj   +1 more source

Estrogen receptor subcellular localization and cardiometabolism

Molecular Metabolism, 2018
Background: In addition to their crucial role in reproduction, estrogens are key regulators of energy and glucose homeostasis and they also exert several cardiovascular protective effects. These beneficial actions are mainly mediated by estrogen receptor
Pierre Gourdy, Maeva Guillaume, Coralie Fontaine, Marine Adlanmerini, Alexandra Montagner, Henrik Laurell, Françoise Lenfant, Jean-François Arnal   +7 more
doaj   +1 more source

Cellular Senescence in Renal and Urinary Tract Disorders

Cells, 2020
Cellular senescence is a state of cell cycle arrest induced by repetitive cell mitoses or different stresses, which is implicated in various physiological or pathological processes.
Yohan Santin, Philippe Lluel, Pascal Rischmann, Xavier Gamé, Jeanne Mialet-Perez, Angelo Parini   +5 more
doaj   +1 more source

Integrated spatial and multimodal single‐cell transcriptomics reveal patient‐dependent cell heterogeneity in splenic marginal zone lymphoma

The Journal of Pathology, Volume 263, Issue 4-5, Page 442-453, August 2024.
Abstract Biological hallmarks of splenic marginal zone lymphoma (SMZL) remain poorly described. Herein, we performed in‐depth SMZL characterization through multimodal single‐cell analyses of paired blood/spleen samples. The 3’‐single‐cell RNA‐sequencing, Cellular Indexing of Transcriptomes and Epitopes by sequencing, and 5’‐V(D)J single‐cell RNA ...
Juan Pablo Cerapio, Pauline Gravelle, Anne Quillet‐Mary, Carine Valle, Frederic Martins, Don‐Marc Franchini, Charlotte Syrykh, Pierre Brousset, Alexandra Traverse‐Glehen, Loic Ysebaert, Jean‐Jacques Fournie, Camille Laurent   +11 more
wiley   +1 more source

The E3 ubiquitin ligase TRIP12 is required for pancreatic acinar cell plasticity and pancreatic carcinogenesis

The Journal of Pathology, Volume 263, Issue 4-5, Page 466-481, August 2024.
Abstract The E3 ubiquitin ligase thyroid hormone receptor interacting protein 12 (TRIP12) has been implicated in pancreatic adenocarcinoma (PDAC) through its role in mediating the degradation of pancreas transcription factor 1a (PTF1a). PTF1a is a transcription factor essential for the acinar differentiation state that is notably diminished during the ...
Manon Brunet, Claire Vargas, Marjorie Fanjul, Damien Varry, Naïma Hanoun, Dorian Larrieu, Laetitia Pieruccioni, Guillaume Labrousse, Hubert Lulka, Florence Capilla, Alban Ricard, Janick Selves, Anne Couvelard, Véronique Gigoux, Pierre Cordelier, Julie Guillermet‐Guibert, Marlène Dufresne, Jérôme Torrisani   +17 more
wiley   +1 more source