Results 31 to 40 of about 2,153 (178)

Endothelial TRIM47 regulates blood-brain barrier integrity and cognition via the KEAP1/NRF2 signalling pathway in mice

Communications Biology
Cerebral small vessel disease (cSVD) is a leading cause of stroke, cognitive decline and dementia, for which no specific mechanism-based treatments are currently available.
Valentin Delobel, Camille Grenier, Romain Boulestreau, Sébastien Rubin, Juliette Vaurs, Béatrice Jaspard-Vinassa, Elina Casas, Muriel Busson, Cloé Combrouze, Carole Proust, Ilana Caro, Jean-Luc Morel, Bruno Bontempi, Aniket Mishra, Stéphanie Debette, Cécile Duplàa, Thierry Couffinhal, Claire Peghaire   +17 more
doaj   +1 more source

Mapping Intestinal Paracellular Perm Eability in Mice: Regional and Cellular Variability Under Physiological and Stimulated Conditions

FASEB BioAdvances, Volume 8, Issue 3, March 2026.
This study analyzed the paracellular permeability of the intestines of healthy mice at a basal level. A new detection method involving tissue incubation for 5 min with luminal fluorescent dyes, such as FM1‐43FX (FM), which bind to accessible plasma (or external) cell membranes, was developed.
Mathilde Miquel, Kadirey Verwaerde, Anissa Edir‐Kibri, Mikael Albin, Florence Blas‐Y‐Estrada, Audrey Samper, Elodie Rousseau‐Bacquie, Hervé Robert, Hélène Eutamène, Vassilia Théodorou, Christine Coméra   +10 more
wiley   +1 more source

G protein stoichiometry dictates biased agonism through distinct receptor-G protein partitioning

Scientific Reports, 2017
Biased agonism at G protein coupled receptors emerges as an opportunity for development of drugs with enhanced benefit/risk balance making biased ligand identification a priority.
Lauriane Onfroy, Ségolène Galandrin, Stéphanie M. Pontier, Marie-Hélène Seguelas, Du N’Guyen, Jean-Michel Sénard, Céline Galés   +6 more
doaj   +1 more source

GHSR agonism increases blood glucose but delays food intake in GHSR hyperresponsive rats

Journal of Neuroendocrinology, Volume 38, Issue 2, February 2026.
GHSR agonism increases blood glucose, inhibits locomotor activity and delays food intake in GHSR hyperresponsive rats. Abstract Severe calorie restriction in mouse models has highlighted the crucial role of the ghrelin system in maintaining glycemia and promoting survival.
Philippe Zizzari, Olalla Ramírez‐Penas, Véronique Pons, Matilda Oujezdska, Ange‐Louis Sammarcelli, Thomas Saint‐Yves, Inès Chevallier‐Chantepie, Lucile Baussart, Vanessa Nhan, Adèle Phalip, Céline Gales, Daniela Cota, Florence Noble, Jacques Pantel   +13 more
wiley   +1 more source

Le lien entre l’alimentation et les maladies cardiovasculaires

One Health & Risk Management, 2023
INTRODUCTION Les maladies cardiovasculaires (MCV) sont la première cause de mortalité avec 17,9 millions de morts, suivi des cancers (9 millions) et des maladies respiratoires (3,9 millions) qui résultent d’une association de facteurs génétiques ...
Ana-Maria ZAVTONI, Cristina DUMITRAS
doaj  

Classical and Counter-Regulatory Renin–Angiotensin System: Potential Key Roles in COVID-19 Pathophysiology

CJC Open, 2021
In the current COVID-19 pandemic, severe acute respiratory syndrome coronavirus 2 uses angiotensin-converting enzyme-2 (ACE-2) receptors for cell entry, leading to ACE-2 dysfunction and downregulation, which disturb the balance between the classical and ...
Moudhi Almutlaq, MSc, Abir Abdullah Alamro, PhD, Fayhan Alroqi, MD, Tlili Barhoumi, PhD   +3 more
doaj   +1 more source

An Autologous, Vascularized and Immunocompetent Tissue Engineered Skin to Highlight Inter‐Individual Variability to Better Understand the Human Wound Healing

Wound Repair and Regeneration, Volume 34, Issue 1, January/February 2026.
ABSTRACT In vitro tissue‐engineered skin models are valuable tools for dermatological research. Yet, they often fail to reproduce the complex interactions among vascular, immune, and cutaneous cells during the wound healing process. In addition, inter‐individual variability response remains poorly understood, limiting our knowledge of the genetic and ...
Emilie Attiogbe, Elodie Mareux, Sébastien Larochelle, Adèle Mauroux, Sandrine Gofflo, Carine Mainzer, Sylvie Bordes, Brigitte Closs, Caroline Gilbert, Véronique J. Moulin   +9 more
wiley   +1 more source

Roles of Estrogens in the Healthy and Diseased Oviparous Vertebrate Liver

Metabolites, 2021
The liver is a vital organ that sustains multiple functions beneficial for the whole organism. It is sexually dimorphic, presenting sex-biased gene expression with implications for the phenotypic differences between males and females.
Blandine Tramunt, Alexandra Montagner, Nguan Soon Tan, Pierre Gourdy, Hervé Rémignon, Walter Wahli   +5 more
doaj   +1 more source

Predicting 1‐year heart failure hospitalization and mortality post‐discharge from the intensive cardiac care unit

ESC Heart Failure, Volume 12, Issue 4, Page 2450-2459, August 2025.
Abstract Aims Despite the high risk of rehospitalization for heart failure (HF) and death among patients admitted to the intensive cardiac care unit (ICCU), no accurate prediction score for these outcomes exists. We aimed to develop a risk score to predict unplanned HF hospitalization and death 1‐year post‐discharge in an unselected cohort of patients ...
Andreas Bugge Tinggaard, Solenn Toupin, Jean Guillaume Dillinger, Clément Delmas, Antonin Trimaille, Claire Bouleti, Guillaume Schurtz, Charles Fauvel, Jean Claude Dib, Stéphane Andrieu, François Roubille, Thomas Levasseur, Guillaume Bonnet, Marouane Boukhris, Thomas Bochaton, Vincent Roule, Laura Delsarte, Albert Boccara, Franck Albert, Franck Boccara, Etienne Puymirat, Henrik Wiggers, Alexandre Mebazaa, Alain Cohen‐Solal, Benjamin G. Chousterman, Patrick Henry, Théo Pezel, for the ADDICT‐ICCU Investigators, Victor Aboyans, Emeric Albert, Franck Albert, Sean Alvain, Nabil Amri, Stéphane Andrieu, Sabir Attou, Simon Auvray, Sonia Azzakani, Ruben Azencot, Marc Bedossa, Franck Boccara, Albert Boccara, Thomas Bochaton, Eric Bonnefoy‐Cudraz, Guillaume Bonnet, Nabil Bouali, Océane Bouchot, Claire Bouleti, Tanissia Boukertouta, Marouane Boukhris, Jean Baptiste Brette, Marjorie Canu, Aures Chaib, Clement Charbonnel, Anne Solene Chaussade, Alexandre Coppens, Yves Cottin, Arthur Darmon, Elena De Angelis, Clément Delmas, Laura Delsarte, Antoine Deney, Jean Claude Dib, Jean‐Guillaume Dillinger, Clemence Docq, Valentin Dupasquier, Meyer Elbaz, Antony El Hadad, Amine El Ouahidi, Nacim Ezzouhairi, Julien Fabre, Damien Fard, Charles Fauvel, Édouard Gerbaud, Martine Gilard, Marc Goralski, Nissim Grinberg, Alain Grentzinger, Marie Hauguel‐Moreau, Patrick Henry, Fabien Huet, Thomas Landemaine, Benoit Lattuca, Léo Lemarchand, Thomas Levasseur, Pascal Lim, Laura Maitre Ballesteros, Nicolas Mansencal, Benjamin Marie, David Martinez, Benoit Merat, Christophe Meune, Damien Millischer, Thomas Moine, Pascal Nhan, Nathalie Noirclerc, Patrick Ohlmann, Théo Pezel, Fabien Picard, Nicolas Piliero, Thibaut Pommier, Etienne Puymirat, Arthur Ramonatxo, Reza Rossanaly Vasram, François Roubille, Vincent Roule, Guillaume Schurtz, Mathilde Stevenard, David Sulman, Fédérico Swedsky, Victoria Tea, Eugénie Thevenet, Christophe Thuaire, Antonin Trimaille, Christophe Tron, Guillaume Viboud, Dominique Yomi, Cyril Zakine   +116 more
wiley   +1 more source

The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α modulation, uncoupling nuclear and membrane activation

EMBO Molecular Medicine, 2014
Estetrol (E4) is a natural estrogen with a long half‐life produced only by the human fetal liver during pregnancy. The crystal structures of the estrogen receptor α (ERα) ligand‐binding domain bound to 17β‐estradiol (E2) and E4 are very similar, as well ...
Anne Abot, Coralie Fontaine, Mélissa Buscato, Romain Solinhac, Gilles Flouriot, Aurélie Fabre, Anne Drougard, Shyamala Rajan, Muriel Laine, Alain Milon, Isabelle Muller, Daniel Henrion, Marine Adlanmerini, Marie‐Cécile Valéra, Anne Gompel, Céline Gerard, Christel Péqueux, Mélanie Mestdagt, Isabelle Raymond‐Letron, Claude Knauf, François Ferriere, Philippe Valet, Pierre Gourdy, Benita S Katzenellenbogen, John A Katzenellenbogen, Françoise Lenfant, Geoffrey L Greene, Jean‐Michel Foidart, Jean‐François Arnal   +28 more
doaj   +1 more source