Cannabidiol-induced Heme oxygenase-1 contributes to modulate the phenotype of hiPSC-derived cardiac fibroblasts from patients with Duchenne muscular dystrophy [PDF]
Redox BiologyDuchenne muscular dystrophy (DMD) is a severe and progressive form of muscular dystrophy caused by mutations in the dystrophin gene. We previously observed that loss of dystrophin in human induced pluripotent stem cell–derived cardiac fibroblasts (hiPSC ...
L. Savchenko +9 more
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Comparative atrial fibrillation risk across Bruton's tyrosine kinase inhibitors in B‐cell malignancies: A nationwide population‐based study [PDF]
British Journal of Haematology, Volume 209, Issue 2, Page 534-543, August 2026.Real‐world nationwide data in B‐cell malignancies reveal a markedly increased 1‐year incidence of hospitalized atrial fibrillation with ibrutinib compared with second‐generation Bruton's tyrosine kinase inhibitors and venetoclax, arguing for closer cardiac surveillance.
Yoann Zelmat +5 more
wiley +2 more sources
Ibrutinib does not prevent kidney fibrosis following acute and chronic injury
Scientific Reports, 2021 Recent studies suggested that ibrutinib, a Bruton tyrosine kinase (BTK) inhibitor, developed for the treatment of chronic lymphocytic leukemia, may prevent NLRP3 inflammasome activation in macrophages, IL-1β secretion and subsequent development of ...
Julie Belliere +8 more
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Cells, 2023 In humans and animal models, intermittent fasting (IF) interventions promote body weight loss, improve metabolic health, and are thought to lower cardiovascular disease risk.
Jules Mérian +9 more
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Platelet P2Y1 receptor exhibits constitutive G protein signaling and β-arrestin 2 recruitment
BMC Biology, 2023 Background Purinergic P2Y1 and P2Y12 receptors (P2Y1-R and P2Y12-R) are G protein-coupled receptors (GPCR) activated by adenosine diphosphate (ADP) to mediate platelet activation, thereby playing a pivotal role in hemostasis and thrombosis. While P2Y12-R
Agnès Ribes +8 more
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eLife, 2023 The rod-shaped adult cardiomyocyte (CM) harbors a unique architecture of its lateral surface with periodic crests, relying on the presence of subsarcolemmal mitochondria (SSM) with unknown role.
Clement Karsenty +22 more
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Remodeling of Ion Channel Trafficking and Cardiac Arrhythmias
Cells, 2021 Both inherited and acquired cardiac arrhythmias are often associated with the abnormal functional expression of ion channels at the cellular level. The complex machinery that continuously traffics, anchors, organizes, and recycles ion channels at the ...
Camille E. Blandin +3 more
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The Sexual Dimorphism of Human Adipose Depots
Biomedicines, 2022 The amount and the distribution of body fat exhibit trajectories that are sex- and human species-specific and both are determinants for health. The enhanced accumulation of fat in the truncal part of the body as a risk factor for cardiovascular and ...
Nathalie Boulet +3 more
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Obesity Drives an Oral Microbiota Signature of Female Patients with Periodontitis: A Pilot Study
Diagnostics, 2021 The aim of this study was to analyze the link between oral microbiota and obesity in humans. We conducted a pilot study including 19 subjects with periodontitis divided into two groups: normo-weighted subjects (NWS) with a body mass index (BMI) between ...
Charlotte Thomas +10 more
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Cholestérol alimentaire et morbi/mortalité cardiovasculaire
Oilseeds and fats, crops and lipids, 2015 Si l’hypercholestérolémie est un facteur de risque avéré des maladies cardiovasculaires, le rôle du cholestérol alimentaire dans la survenue de ces maladies reste discuté.
Hansel Boris, Giral Philipe
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