Results 11 to 20 of about 2,153 (178)

Atomic force microscopy-single-molecule force spectroscopy unveils GPCR cell surface architecture

Communications Biology, 2022
Atomic force microscopy-based single molecule force spectroscopy reveals the unfolding of G-protein coupled receptors on the surface of living mammalian cells.
Etienne Dague, Véronique Pons, Alexandre Roland, Jean-Marc Azaïs, Silvia Arcucci, Véronique Lachaize, Samuel Velmont, Emmanuelle Trevisiol, Du N’Guyen, Jean-Michel Sénard, Céline Galés   +10 more
doaj   +1 more source

Intermittent Fasting Resolves Dyslipidemia and Atherogenesis in Apolipoprotein E-Deficient Mice in a Diet-Dependent Manner, Irrespective of Sex

Cells, 2023
In humans and animal models, intermittent fasting (IF) interventions promote body weight loss, improve metabolic health, and are thought to lower cardiovascular disease risk.
Jules Mérian, Lamia Ghezali, Charlotte Trenteseaux, Thibaut Duparc, Diane Beuzelin, Vanessa Bouguetoch, Guillaume Combes, Nabil Sioufi, Laurent O. Martinez, Souad Najib   +9 more
doaj   +1 more source

Ibrutinib does not prevent kidney fibrosis following acute and chronic injury

Scientific Reports, 2021
Recent studies suggested that ibrutinib, a Bruton tyrosine kinase (BTK) inhibitor, developed for the treatment of chronic lymphocytic leukemia, may prevent NLRP3 inflammasome activation in macrophages, IL-1β secretion and subsequent development of ...
Julie Belliere, Audrey Casemayou, Eloïse Colliou, Hélène El Hachem, Clément Kounde, Alexis Piedrafita, Guylène Feuillet, Joost P. Schanstra, Stanislas Faguer   +8 more
doaj   +1 more source

Platelet P2Y1 receptor exhibits constitutive G protein signaling and β-arrestin 2 recruitment

BMC Biology, 2023
Background Purinergic P2Y1 and P2Y12 receptors (P2Y1-R and P2Y12-R) are G protein-coupled receptors (GPCR) activated by adenosine diphosphate (ADP) to mediate platelet activation, thereby playing a pivotal role in hemostasis and thrombosis. While P2Y12-R
Agnès Ribes, Cédric Garcia, Marie-Pierre Gratacap, Evi Kostenis, Laurent O. Martinez, Bernard Payrastre, Jean-Michel Sénard, Céline Galés, Véronique Pons   +8 more
doaj   +1 more source

Ephrin-B1 regulates the adult diastolic function through a late postnatal maturation of cardiomyocyte surface crests

eLife, 2023
The rod-shaped adult cardiomyocyte (CM) harbors a unique architecture of its lateral surface with periodic crests, relying on the presence of subsarcolemmal mitochondria (SSM) with unknown role.
Clement Karsenty, Celine Guilbeau-Frugier, Gaël Genet, Marie-Helene Seguelas, Philippe Alzieu, Olivier Cazorla, Alexandra Montagner, Yuna Blum, Caroline Dubroca, Julile Maupoint, Blandine Tramunt, Marie Cauquil, Thierry Sulpice, Sylvain Richard, Silvia Arcucci, Remy Flores-Flores, Nicolas Pataluch, Romain Montoriol, Pierre Sicard, Antoine Deney, Thierry Couffinhal, Jean-Michel Senard, Celine Galés   +22 more
doaj   +1 more source

The Sexual Dimorphism of Human Adipose Depots

Biomedicines, 2022
The amount and the distribution of body fat exhibit trajectories that are sex- and human species-specific and both are determinants for health. The enhanced accumulation of fat in the truncal part of the body as a risk factor for cardiovascular and ...
Nathalie Boulet, Anais Briot, Jean Galitzky, Anne Bouloumié   +3 more
doaj   +1 more source

Remodeling of Ion Channel Trafficking and Cardiac Arrhythmias

Cells, 2021
Both inherited and acquired cardiac arrhythmias are often associated with the abnormal functional expression of ion channels at the cellular level. The complex machinery that continuously traffics, anchors, organizes, and recycles ion channels at the ...
Camille E. Blandin, Basile J. Gravez, Stéphane N. Hatem, Elise Balse   +3 more
doaj   +1 more source

SARS-CoV-2 Omicron variant infection affects blood platelets, a comparative analysis with Delta variant

Frontiers in Immunology, 2023
IntroductionIn November 2021, the SARS-CoV-2 Omicron variant of concern has emerged and is currently dominating the COVID-19 pandemic over the world.
Cédric Garcia, Cédric Garcia, Baptiste Compagnon, Baptiste Compagnon, Agnès Ribes, Agnès Ribes, Sophie Voisin, Sophie Voisin, Fanny Vardon-Bounes, Fanny Vardon-Bounes, Bernard Payrastre, Bernard Payrastre   +11 more
doaj   +1 more source

Obesity Drives an Oral Microbiota Signature of Female Patients with Periodontitis: A Pilot Study

Diagnostics, 2021
The aim of this study was to analyze the link between oral microbiota and obesity in humans. We conducted a pilot study including 19 subjects with periodontitis divided into two groups: normo-weighted subjects (NWS) with a body mass index (BMI) between ...
Charlotte Thomas, Matthieu Minty, Thibault Canceill, Pascale Loubières, Vincent Azalbert, François Tercé, Camille Champion, Rémy Burcelin, Pierre Barthet, Sara Laurencin-Dalicieux, Vincent Blasco-Baque   +10 more
doaj   +1 more source

Cholestérol alimentaire et morbi/mortalité cardiovasculaire

Oilseeds and fats, crops and lipids, 2015
Si l’hypercholestérolémie est un facteur de risque avéré des maladies cardiovasculaires, le rôle du cholestérol alimentaire dans la survenue de ces maladies reste discuté.
Hansel Boris, Giral Philipe
doaj   +1 more source